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52.662037 Tz (U.S. ) Tj 1.516667 0 Td 49.200337 Tz (Provisional ) Tj 3.461111 0 Td 49.151235 Tz (Patent ) Tj 1.925 0 Td 60.185185 Tz (Applica ) Tj 51.428571 0 0 51.428571 0 2346.769433 Tm 6.338889 0 Td 48.611111 Tz (tion ) Tj 1.458333 0 Td 45.37037 Tz (Ser. ) Tj 1.4 0 Td 58.333333 Tz (No. ) Tj 1.380556 0 Td 52.441077 Tz (61/234,803, ) Tj 3.752778 0 Td 42.777778 Tz (filed ) Tj 1.555556 0 Td 59.143519 Tz (Aug. ) Tj 1.808333 0 Td 45.37037 Tz (18, ) Tj 1.108333 0 Td 55.092593 Tz (2009. ) Tj 1.925 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 46.450617 Tz (entire ) Tj 51.428571 0 0 51.428571 0 2306.811665 Tm 6.358333 0 Td 50.231481 Tz (contents ) Tj 2.644444 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 55.902778 Tz (each ) Tj 1.516667 0 Td 49.200337 Tz (application ) Tj 3.441667 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 55.092593 Tz (hereby ) Tj 2.216667 0 Td 50.771605 Tz (incorporated ) Tj 3.830556 0 Td 61.574074 Tz (by ) Tj 0.933333 0 Td 58.333333 Tz (ref ) Tj 40 0 0 40 0 2266 Tm 8.175 0 Td 68.055556 Tz (erence ) Tj 2.65 0 Td 61.309524 Tz (herein. ) Tj 38.571429 0 0 38.571429 0 2185 Tm 16.748148 0 Td 112.345679 Tz (BACKGROUND ) Tj 51.428571 0 0 51.428571 0 2092.396717 Tm 7.097222 0 Td 66.435185 Tz (As ) Tj 1.127778 0 Td 62.654321 Tz (humans ) Tj 2.605556 0 Td 43.75 Tz (live ) Tj 1.361111 0 Td 47.685185 Tz (longer, ) Tj 2.333333 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 53.472222 Tz (occurrence ) Tj 3.519444 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 46.990741 Tz (severity ) Tj 2.586111 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 2051.023697 Tm 6.358333 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 50.968013 Tz (pathologies ) Tj 3.558333 0 Td 54.282407 Tz (such ) Tj 1.458333 0 Td 51.851852 Tz (as ) Tj 0.777778 0 Td 56.17284 Tz (glaucoma, ) Tj 3.247222 0 Td 55.555556 Tz (macular ) Tj 2.469444 0 Td 50.106838 Tz (degeneration, ) Tj 48.571429 0 0 48.571429 0 2005 Tm 6.732353 0 Td 59.803922 Tz (macular ) Tj 2.655882 0 Td 61.764706 Tz (edema, ) Tj 2.408824 0 Td 62.908497 Tz (and ) Tj 1.297059 0 Td 53.75817 Tz (the ) Tj 1.173529 0 Td 47.181373 Tz (like ) Tj 1.317647 0 Td 54.901961 Tz (continues ) Tj 3.15 0 Td 48.039216 Tz (to ) Tj 0.802941 0 Td 49.56427 Tz (increase. ) Tj 51.428571 0 0 51.428571 0 1963.161616 Tm 7.097222 0 Td 62.384259 Tz (Glaucoma ) Tj 3.208333 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 56.712963 Tz (an ) Tj 0.933333 0 Td 45.37037 Tz (irreversible ) Tj 3.461111 0 Td 50.378788 Tz (progressive ) Tj 3.538889 0 Td 47.962963 Tz (optic ) Tj 1.691667 0 Td 54.12037 Tz (neuropathy ) Tj 51.428571 0 0 51.428571 0 1918.533499 Tm 6.358333 0 Td 49.85755 Tz (characterized ) Tj 4.102778 0 Td 61.574074 Tz (by ) Tj 1.011111 0 Td 55.555556 Tz (changes ) Tj 2.605556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 49.358974 Tz (parapapillary ) Tj 4.122222 0 Td 43.518519 Tz (retinal ) Tj 2.119444 0 Td 53.148148 Tz (nerve ) Tj 51.428571 0 0 51.428571 0 1875.985185 Tm 6.358333 0 Td 44.722222 Tz (fiber ) Tj 1.516667 0 Td 49.259259 Tz (layer ) Tj 1.633333 0 Td 65.354938 Tz (\(RNFL\) ) Tj 2.508333 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 47.962963 Tz (optic ) Tj 1.633333 0 Td 44.074074 Tz (disc. ) Tj 1.516667 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 66.759259 Tz (human ) Tj 2.197222 0 Td 55.092593 Tz (eye ) Tj 1.147222 0 Td 54.012346 Tz (has ) Tj 1.166667 0 Td 54.444444 Tz (about ) Tj 51.428571 0 0 51.428571 0 1833.340206 Tm 6.358333 0 Td 52.662037 Tz (0.75 ) Tj 1.516667 0 Td 45.37037 Tz (to ) Tj 0.875 0 Td 48.611111 Tz (1.25 ) Tj 1.477778 0 Td 48.611111 Tz (million ) Tj 2.333333 0 Td 43.518519 Tz (retinal ) Tj 2.061111 0 Td 52.662037 Tz (ganglion ) Tj 2.761111 0 Td 44.722222 Tz (cells ) Tj 1.594444 0 Td 46.180556 Tz (that ) Tj 1.361111 0 Td 49.421296 Tz (transmit ) Tj 2.605556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1791.55863 Tm 6.358333 0 Td 48.070988 Tz (visual ) Tj 2.002778 0 Td 51.851852 Tz (information ) Tj 3.733333 0 Td 56.712963 Tz (from ) Tj 1.652778 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 57.253086 Tz (eye ) Tj 1.322222 0 Td 42.12963 Tz (to ) Tj 0.816667 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 45.910494 Tz (brain. ) Tj 1.905556 0 Td 61.574074 Tz (At ) Tj 0.972222 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 46.180556 Tz (cellular ) Tj 51.428571 0 0 51.428571 0 1752.599493 Tm 6.358333 0 Td 43.209877 Tz (level, ) Tj 1.827778 0 Td 59.143519 Tz (glaucoma ) Tj 3.111111 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 49.608262 Tz (characterized ) Tj 4.141667 0 Td 59.953704 Tz (by ) Tj 0.991667 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 50.673401 Tz (progressive ) Tj 3.616667 0 Td 51.851852 Tz (death ) Tj 1.847222 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1710.952746 Tm 6.338889 0 Td 50.555556 Tz (these ) Tj 1.730556 0 Td 44.074074 Tz (cells ) Tj 1.555556 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 46.018519 Tz (their ) Tj 1.555556 0 Td 56.388889 Tz (axons ) Tj 1.905556 0 Td 59.953704 Tz (by ) Tj 0.952778 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 51.388889 Tz (process ) Tj 2.411111 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (apoptosis ) Tj 2.955556 0 Td 46.990741 Tz (that ) Tj 1.322222 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1669.702233 Tm 6.358333 0 Td 58.333333 Tz (measured ) Tj 2.994444 0 Td 50.231481 Tz (as ) Tj 0.816667 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 50.673401 Tz (progressive ) Tj 3.558333 0 Td 50.636574 Tz (thinning ) Tj 2.663889 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 52.5 Tz (nerve ) Tj 1.827778 0 Td 44.074074 Tz (fiber ) Tj 1.536111 0 Td 49.259259 Tz (layer ) Tj 1.633333 0 Td 61.574074 Tz (and ) Tj 52.857143 0 0 52.857143 0 1625.845966 Tm 6.186486 0 Td 47.297297 Tz (neuroretinal ) Tj 3.651351 0 Td 51.501502 Tz (rim ) Tj 1.135135 0 Td 45.720721 Tz (tissue ) Tj 1.835135 0 Td 58.333333 Tz (of ) Tj 0.775676 0 Td 49.399399 Tz (the ) Tj 1.078378 0 Td 46.666667 Tz (optic ) Tj 1.627027 0 Td 42.882883 Tz (disc. ) Tj 1.494595 0 Td 62.012012 Tz (The ) Tj 1.286486 0 Td 52.633403 Tz (heterogeneous ) Tj 51.428571 0 0 51.428571 0 1584.848329 Tm 6.358333 0 Td 50.771605 Tz (nature ) Tj 2.1 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 50 Tz (disease ) Tj 2.333333 0 Td 60.493827 Tz (and ) Tj 1.341667 0 Td 56.064815 Tz (redundancy ) Tj 3.655556 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 46.990741 Tz (visual ) Tj 1.963889 0 Td 56.17284 Tz (system ) Tj 51.428571 0 0 51.428571 0 1544.668258 Tm 6.358333 0 Td 61.574074 Tz (makes ) Tj 1.963889 0 Td 59.143519 Tz (glaucoma ) Tj 2.955556 0 Td 51.041667 Tz (very ) Tj 1.4 0 Td 42.12963 Tz (difficult ) Tj 2.372222 0 Td 45.37037 Tz (to ) Tj 0.661111 0 Td 46.990741 Tz (identify ) Tj 2.372222 0 Td 48.611111 Tz (in ) Tj 0.680556 0 Td 47.962963 Tz (early ) Tj 1.594444 0 Td 48.611111 Tz (stages ) Tj 1.866667 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1502.462264 Tm 6.358333 0 Td 47.395833 Tz (disease, ) Tj 2.411111 0 Td 49.421296 Tz (thus ) Tj 1.361111 0 Td 59.953704 Tz (making ) Tj 2.255556 0 Td 59.143519 Tz (glaucoma ) Tj 2.955556 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 50.925926 Tz (leading ) Tj 2.236111 0 Td 54.444444 Tz (cause ) Tj 1.769444 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 50.411523 Tz (blindness ) Tj 40 0 0 40 0 1465 Tm 8.15 0 Td 70.416667 Tz (worldwide. ) Tj 51.428571 0 0 51.428571 0 1416.917603 Tm 7.097222 0 Td 58.333333 Tz (Macular ) Tj 2.566667 0 Td 51.851852 Tz (degeneration ) Tj 3.888889 0 Td 38.888889 Tz (is ) Tj 0.602778 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 53.703704 Tz (medical ) Tj 2.45 0 Td 50.771605 Tz (condition ) Tj 2.877778 0 Td 45.37037 Tz (that ) Tj 1.225 0 Td 44.907407 Tz (results ) Tj 2.041667 0 Td 50.231481 Tz (in ) Tj 51.428571 0 0 51.428571 0 1374 Tm 6.358333 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 42.939815 Tz (lost ) Tj 1.166667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.151235 Tz (vision ) Tj 1.925 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 50.771605 Tz (center ) Tj 1.925 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 46.990741 Tz (visual ) Tj 1.866667 0 Td 42.777778 Tz (field ) Tj 1.458333 0 Td 46.990741 Tz (\(the ) Tj 1.263889 0 Td 55.092593 Tz (macula'\) ) Tj 51.428571 0 0 51.428571 0 1333.985112 Tm 6.338889 0 Td 55.555556 Tz (because ) Tj 2.488889 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 63.194444 Tz (damage ) Tj 2.469444 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 42.12963 Tz (retina. ) Tj 2.022222 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 53.796296 Tz (dry ) Tj 1.847222 0 Td 51.851852 Tz (form, ) Tj 1.788889 0 Td 56.018519 Tz (macular ) Tj 51.428571 0 0 51.428571 0 1293.166271 Tm 6.358333 0 Td 51.851852 Tz (degeneration ) Tj 3.888889 0 Td 40.509259 Tz (is ) Tj 0.661111 0 Td 54.552469 Tz (caused ) Tj 2.1 0 Td 58.333333 Tz (by ) Tj 0.855556 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 54.552469 Tz (accumulation ) Tj 4.102778 0 Td 53.472222 Tz (of ) Tj 0.7 0 Td 46.585648 Tz (cellular ) Tj 2.352778 0 Td 49.151235 Tz (debris ) Tj 51.428571 0 0 51.428571 0 1249 Tm 6.377778 0 Td 51.203704 Tz (\("drusen'\) ) Tj 3.227778 0 Td 56.944444 Tz (between ) Tj 2.605556 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 45.37037 Tz (retina ) Tj 1.808333 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 49.331276 Tz (choroids. ) Tj 2.897222 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 57.037037 Tz (wet' ) Tj 51.428571 0 0 51.428571 0 1209.139896 Tm 6.358333 0 Td 53.148148 Tz (form, ) Tj 1.847222 0 Td 55.740741 Tz (blood ) Tj 1.925 0 Td 47.685185 Tz (vessels ) Tj 2.294444 0 Td 59.953704 Tz (grow ) Tj 1.75 0 Td 58.333333 Tz (up ) Tj 0.972222 0 Td 57.523148 Tz (from ) Tj 1.672222 0 Td 47.530864 Tz (the ) Tj 1.127778 0 Td 51.851852 Tz (choroids ) Tj 2.761111 0 Td 55.092593 Tz (behind ) Tj 2.236111 0 Td 49.691358 Tz (the ) Tj 40 0 0 40 0 1174 Tm 8.175 0 Td 55.357143 Tz (retina. ) Tj 40 0 0 40 0 1132 Tm 9.125 0 Td 75 Tz (Macular ) Tj 3.425 0 Td 81.666667 Tz (edema ) Tj 2.775 0 Td 50 Tz (is ) Tj 0.925 0 Td 70.833333 Tz (a ) Tj 0.8 0 Td 69.047619 Tz (medical ) Tj 3.25 0 Td 64.351852 Tz (condition ) Tj 3.825 0 Td 59.375 Tz (that ) Tj 1.725 0 Td 67.361111 Tz (occurs ) Tj 2.75 0 Td 86.458333 Tz (when ) Tj 51.428571 0 0 51.428571 0 1085.232558 Tm 6.358333 0 Td 44.722222 Tz (fluid ) Tj 1.477778 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 48.611111 Tz (protein ) Tj 2.216667 0 Td 49.826389 Tz (deposits ) Tj 2.566667 0 Td 46.296296 Tz (collect ) Tj 2.1 0 Td 59.953704 Tz (on ) Tj 0.913889 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 55.740741 Tz (under ) Tj 1.788889 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 57.253086 Tz (macula ) Tj 2.216667 0 Td 60.493827 Tz (and ) Tj 40 0 0 40 0 1049 Tm 8.175 0 Td 70 Tz (cause ) Tj 2.3 0 Td 65.277778 Tz (the ) Tj 1.45 0 Td 73.611111 Tz (macula ) Tj 2.85 0 Td 60.416667 Tz (to ) Tj 1 0 Td 64.880952 Tz (thicken ) Tj 2.975 0 Td 75 Tz (and ) Tj 1.6 0 Td 59.722222 Tz (Swell. ) Tj 51.428571 0 0 51.428571 0 1001.454545 Tm 7.116667 0 Td 47.314815 Tz (Structural ) Tj 3.344444 0 Td 57.407407 Tz (damage, ) Tj 2.916667 0 Td 55.092593 Tz (such ) Tj 1.788889 0 Td 51.851852 Tz (as ) Tj 1.186111 0 Td 74.537037 Tz (RNFL ) Tj 2.275 0 Td 46.585648 Tz (defects, ) Tj 2.722222 0 Td 40.509259 Tz (is ) Tj 0.952778 0 Td 51.851852 Tz (often ) Tj 51.428571 0 0 51.428571 0 960.424821 Tm 6.358333 0 Td 54.6875 Tz (observed ) Tj 2.780556 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 52.662037 Tz (precedes ) Tj 2.741667 0 Td 48.935185 Tz (functional ) Tj 3.130556 0 Td 57.407407 Tz (damage. ) Tj 2.625 0 Td 56.944444 Tz (Medical ) Tj 2.586111 0 Td 48.206019 Tz (devices, ) Tj 51.428571 0 0 51.428571 0 920.776156 Tm 6.377778 0 Td 54.282407 Tz (Such ) Tj 1.477778 0 Td 50.231481 Tz (as ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 53.877315 Tz (scanning ) Tj 2.780556 0 Td 46.018519 Tz (laser ) Tj 1.536111 0 Td 50.231481 Tz (polarimeters ) Tj 3.811111 0 Td 69.675926 Tz (\(GDX ) Tj 1.827778 0 Td 47.530864 Tz (devices\), ) Tj 2.8 0 Td 55.902778 Tz (opti ) Tj 51.428571 0 0 51.428571 0 878.40276 Tm 6.358333 0 Td 46.450617 Tz (cal ) Tj 1.166667 0 Td 54.73251 Tz (coherence ) Tj 3.286111 0 Td 56.388889 Tz (tomographs ) Tj 3.733333 0 Td 56.944444 Tz (\(OCTs\), ) Tj 2.702778 0 Td 60.493827 Tz (and ) Tj 1.4 0 Td 53.472222 Tz (Heidelberg ) Tj 3.558333 0 Td 45.37037 Tz (retina ) Tj 51.428571 0 0 51.428571 0 836.939698 Tm 6.338889 0 Td 57.361111 Tz (tomographs ) Tj 3.655556 0 Td 46.990741 Tz (that ) Tj 1.361111 0 Td 56.944444 Tz (measure ) Tj 2.586111 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 66.111111 Tz (RNFL, ) Tj 2.216667 0 Td 69.135802 Tz (may ) Tj 1.458333 0 Td 49.691358 Tz (aid ) Tj 1.108333 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 47.962963 Tz (early ) Tj 1.652778 0 Td 62.384259 Tz (diag ) Tj 51.428571 0 0 51.428571 0 796.146264 Tm 6.358333 0 Td 49.259259 Tz (nosis ) Tj 1.691667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 43.518519 Tz (retinal ) Tj 2.041667 0 Td 50.673401 Tz (pathologies ) Tj 3.538889 0 Td 55.092593 Tz (such ) Tj 1.516667 0 Td 48.611111 Tz (as ) Tj 0.777778 0 Td 55.452675 Tz (glaucoma. ) Tj 51.428571 0 0 51.428571 0 752.535764 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.438889 0 Td 49.537037 Tz (current ) Tj 2.391667 0 Td 48.611111 Tz (analysis ) Tj 2.683333 0 Td 38.888889 Tz (is ) Tj 0.816667 0 Td 49.074074 Tz (usually ) Tj 2.411111 0 Td 49.537037 Tz (limited ) Tj 2.372222 0 Td 46.990741 Tz (to ) Tj 0.913889 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 64.814815 Tz (mean ) Tj 1.866667 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 710.582524 Tm 6.377778 0 Td 76.967593 Tz (RNFL ) Tj 1.983333 0 Td 45.37037 Tz (at ) Tj 0.719444 0 Td 45.730453 Tz (different ) Tj 2.625 0 Td 48.251029 Tz (locations ) Tj 2.780556 0 Td 56.17284 Tz (around ) Tj 2.197222 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 48.021886 Tz (parapillary ) Tj 3.363889 0 Td 44.830247 Tz (retina ) Tj 1.769444 0 Td 45.37037 Tz (at ) Tj 0.7 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 669.36715 Tm 6.358333 0 Td 52.5 Tz (given ) Tj 1.711111 0 Td 49.826389 Tz (distance ) Tj 2.527778 0 Td 57.523148 Tz (from ) Tj 1.516667 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 47.962963 Tz (optic ) Tj 1.575 0 Td 48.611111 Tz (disc ) Tj 1.283333 0 Td 51.851852 Tz (as ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 50.231481 Tz (function ) Tj 2.547222 0 Td 51.851852 Tz (of ) Tj 0.7 0 Td 48.611111 Tz (angle. ) Tj 1.886111 0 Td 61.574074 Tz (Such ) Tj 51.428571 0 0 51.428571 0 629.764706 Tm 6.338889 0 Td 50.411523 Tz (thickness ) Tj 3.033333 0 Td 51.311728 Tz (graph, ) Tj 2.138889 0 Td 49.421296 Tz (also ) Tj 1.516667 0 Td 64.814815 Tz (known ) Tj 2.275 0 Td 48.611111 Tz (as ) Tj 0.894444 0 Td 51.49177 Tz (temporal, ) Tj 3.111111 0 Td 46.8107 Tz (Superior, ) Tj 2.877778 0 Td 44.830247 Tz (nasal, ) Tj 51.428571 0 0 51.428571 0 586.909091 Tm 6.358333 0 Td 43.209877 Tz (inferior, ) Tj 2.663889 0 Td 53.877315 Tz (temporal ) Tj 2.955556 0 Td 59.722222 Tz (\(TSNIT\) ) Tj 2.858333 0 Td 54.444444 Tz (graph ) Tj 1.983333 0 Td 58.333333 Tz (of ) Tj 0.972222 0 Td 49.331276 Tz (thickness ) Tj 3.033333 0 Td 47.530864 Tz (for ) Tj 1.147222 0 Td 55.092593 Tz (a ) Tj 0.719444 0 Td 47.800926 Tz (ring ) Tj 51.428571 0 0 51.428571 0 546.119403 Tm 6.358333 0 Td 56.17284 Tz (around ) Tj 2.255556 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 43.518519 Tz (retina, ) Tj 2.080556 0 Td 59.62963 Tz (shows ) Tj 2.022222 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 51.388889 Tz (general ) Tj 2.411111 0 Td 58.627946 Tz (double-hump ) Tj 4.102778 0 Td 48.148148 Tz (pattern ) Tj 2.294444 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 503.40404 Tm 6.338889 0 Td 50.411523 Tz (thickness ) Tj 2.994444 0 Td 57.253086 Tz (due ) Tj 1.263889 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 66.435185 Tz (much ) Tj 1.827778 0 Td 49.537037 Tz (greater ) Tj 2.313889 0 Td 61.574074 Tz (number ) Tj 2.430556 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 53.06713 Tz (ganglion ) Tj 2.8 0 Td 43.75 Tz (cell ) Tj 51.428571 0 0 51.428571 0 464.540741 Tm 6.358333 0 Td 56.388889 Tz (axons ) Tj 1.944444 0 Td 50.231481 Tz (entering ) Tj 2.625 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 48.611111 Tz (disc ) Tj 1.438889 0 Td 48.611111 Tz (Superiorly ) Tj 3.169444 0 Td 59.41358 Tz (and ) Tj 1.322222 0 Td 43.013468 Tz (inferiorly. ) Tj 3.091667 0 Td 57.118056 Tz (Although ) Tj 51.428571 0 0 51.428571 0 421.084577 Tm 6.338889 0 Td 50.771605 Tz (the ) Tj 1.205556 0 Td 64.00463 Tz (mean ) Tj 1.866667 0 Td 75.347222 Tz (RNFL ) Tj 2.080556 0 Td 56.17284 Tz (can ) Tj 1.283333 0 Td 50.231481 Tz (discriminate ) Tj 3.869444 0 Td 55.092593 Tz (groups ) Tj 2.255556 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 56.17284 Tz (glaucomatous ) Tj 51.428571 0 0 51.428571 0 377.083744 Tm 6.358333 0 Td 48.611111 Tz (individuals ) Tj 3.558333 0 Td 57.523148 Tz (from ) Tj 1.75 0 Td 51.311728 Tz (ocular ) Tj 2.158333 0 Td 50.925926 Tz (healthy ) Tj 2.469444 0 Td 46.990741 Tz (individuals, ) Tj 3.733333 0 Td 45.601852 Tz (classification ) Tj 51.428571 0 0 51.428571 0 338.307049 Tm 6.358333 0 Td 55.976431 Tz (performance ) Tj 3.811111 0 Td 56.17284 Tz (can ) Tj 1.147222 0 Td 58.333333 Tz (be ) Tj 0.855556 0 Td 48.611111 Tz (quite ) Tj 1.613889 0 Td 48.611111 Tz (limited ) Tj 2.177778 0 Td 64.814815 Tz (when ) Tj 1.730556 0 Td 52.5 Tz (using ) Tj 1.730556 0 Td 64.00463 Tz (mean ) Tj 1.691667 0 Td 50.05144 Tz (thickness ) Tj 40 0 0 40 0 301 Tm 8.175 0 Td 62.5 Tz (for ) Tj 1.325 0 Td 56.388889 Tz (classification. ) Tj 48.571429 0 0 48.571429 0 253 Tm 7.535294 0 Td 69.771242 Tz (Due ) Tj 1.4 0 Td 46.323529 Tz (to ) Tj 0.7 0 Td 45.465686 Tz (this ) Tj 1.235294 0 Td 47.46732 Tz (issue, ) Tj 1.832353 0 Td 52.614379 Tz (the ) Tj 1.029412 0 Td 74.117647 Tz (TSNIT ) Tj 2.326471 0 Td 50.183824 Tz (features ) Tj 2.532353 0 Td 60.04902 Tz (have ) Tj 1.564706 0 Td 60.906863 Tz (been ) Tj 1.585294 0 Td 64.433551 Tz (mathemati ) Tj 51.428571 0 0 51.428571 0 213.777778 Tm 6.358333 0 Td 46.666667 Tz (cally ) Tj 1.594444 0 Td 49.358974 Tz (characterized ) Tj 4.005556 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 32.407407 Tz (it ) Tj 0.563889 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 55.092593 Tz (proven ) Tj 2.138889 0 Td 46.180556 Tz (that ) Tj 1.263889 0 Td 50.231481 Tz (shape-analysis ) Tj 4.413889 0 Td 68.865741 Tz (meth ) Tj 51.428571 0 0 51.428571 0 169.306329 Tm 6.358333 0 Td 56.17284 Tz (ods ) Tj 1.322222 0 Td 44.560185 Tz (like ) Tj 1.4 0 Td 47.800926 Tz (Fast ) Tj 1.477778 0 Td 50.462963 Tz (Fourier ) Tj 2.372222 0 Td 52.256944 Tz (Analysis ) Tj 2.838889 0 Td 57.685185 Tz (\(FFA\) ) Tj 2.022222 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 52.5 Tz (Wavelet-Fourier ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.775 0 Td 74.537037 Tz (2 ) Tj 51.428571 0 0 51.428571 0 2916.24878 Tm 25.297222 0 Td 52.662037 Tz (Analysis ) Tj 2.8 0 Td 68.703704 Tz (\(WFA\) ) Tj 2.313889 0 Td 55.902778 Tz (have ) Tj 1.594444 0 Td 46.990741 Tz (better ) Tj 1.925 0 Td 44.907407 Tz (classification ) Tj 4.044444 0 Td 54.822531 Tz (performances ) Tj 4.219444 0 Td 50.231481 Tz (in ) Tj 51.428571 0 0 51.428571 0 2875.815534 Tm 25.297222 0 Td 46.234568 Tz (differentiating ) Tj 4.375 0 Td 57.87037 Tz (between ) Tj 2.663889 0 Td 56.442901 Tz (glaucomatous ) Tj 4.316667 0 Td 53.472222 Tz (eyes ) Tj 1.536111 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 50.925926 Tz (healthy ) Tj 38.571429 0 0 38.571429 0 2832 Tm 33.72963 0 Td 63.950617 Tz (eyes. ) Tj 51.428571 0 0 51.428571 0 2786.723834 Tm 26.036111 0 Td 50.231481 Tz (Fast ) Tj 1.361111 0 Td 50.925926 Tz (Fourier ) Tj 2.275 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 58.981481 Tz (\(FFA\) ) Tj 1.925 0 Td 45.775463 Tz (linearly ) Tj 2.372222 0 Td 52.391975 Tz (breaks ) Tj 2.061111 0 Td 59.953704 Tz (up ) Tj 0.875 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 47.395833 Tz (features ) Tj 51.428571 0 0 51.428571 0 2743 Tm 25.297222 0 Td 46.180556 Tz (into ) Tj 1.380556 0 Td 48.611111 Tz (sinusoidal ) Tj 3.169444 0 Td 51.851852 Tz (curves ) Tj 2.119444 0 Td 35.648148 Tz (\(i.e., ) Tj 1.536111 0 Td 46.180556 Tz (into ) Tj 1.341667 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 43.209877 Tz (set ) Tj 1.030556 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 50.05144 Tz (sinusoids ) Tj 2.936111 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 59.62963 Tz (which ) Tj 51.428571 0 0 51.428571 0 2702.594022 Tm 25.297222 0 Td 55.092593 Tz (each ) Tj 1.516667 0 Td 50.636574 Tz (sinusoid ) Tj 2.605556 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 45.730453 Tz (different ) Tj 2.663889 0 Td 44.290123 Tz (scale, ) Tj 1.808333 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 51.851852 Tz (frequency\) ) Tj 3.266667 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 50.231481 Tz (thus ) Tj 1.380556 0 Td 55.092593 Tz (has ) Tj 51.428571 0 0 51.428571 0 2661.06383 Tm 25.297222 0 Td 51.851852 Tz (a ) Tj 0.661111 0 Td 46.090535 Tz (different ) Tj 2.838889 0 Td 61.574074 Tz (number ) Tj 2.488889 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 64.814815 Tz (humps ) Tj 2.275 0 Td 50.771605 Tz (across ) Tj 2.158333 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 69.351852 Tz (TSNIT ) Tj 2.411111 0 Td 49.421296 Tz (data ) Tj 1.536111 0 Td 39.699074 Tz (set. ) Tj 51.428571 0 0 51.428571 0 2620.042155 Tm 25.297222 0 Td 52.716049 Tz (Wavelet-Fourier ) Tj 4.841667 0 Td 49.016204 Tz (analysis ) Tj 2.508333 0 Td 52.391975 Tz (adopts ) Tj 2.041667 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 46.990741 Tz (discrete ) Tj 2.391667 0 Td 52.777778 Tz (wavelet ) Tj 2.372222 0 Td 52.572016 Tz (transform ) Tj 51.428571 0 0 51.428571 0 2577.403846 Tm 25.316667 0 Td 63.194444 Tz (\(DWT\), ) Tj 2.45 0 Td 58.981481 Tz (which ) Tj 1.963889 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 61.574074 Tz (more ) Tj 1.613889 0 Td 47.395833 Tz (suitable ) Tj 2.469444 0 Td 47.530864 Tz (for ) Tj 0.991667 0 Td 52.572016 Tz (analyzing ) Tj 3.033333 0 Td 46.882716 Tz (discontinuities ) Tj 51.428571 0 0 51.428571 0 2539.727928 Tm 25.297222 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 52.932099 Tz (abrupt ) Tj 2.080556 0 Td 55.092593 Tz (changes ) Tj 2.527778 0 Td 52.211934 Tz (contained ) Tj 2.994444 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 44.965278 Tz (signals. ) Tj 51.428571 0 0 51.428571 0 2496.094437 Tm 26.036111 0 Td 57.118056 Tz (However, ) Tj 2.936111 0 Td 54.282407 Tz (both ) Tj 1.555556 0 Td 69.135802 Tz (FFA ) Tj 1.419444 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 85.339506 Tz (WFA ) Tj 1.75 0 Td 51.527778 Tz (techniques ) Tj 3.305556 0 Td 47.962963 Tz (yield ) Tj 1.633333 0 Td 53.472222 Tz (only ) Tj 1.536111 0 Td 73.45679 Tz (mar ) Tj 51.428571 0 0 51.428571 0 2456.758105 Tm 25.297222 0 Td 47.314815 Tz (ginal ) Tj 1.808333 0 Td 57.253086 Tz (improvements ) Tj 4.511111 0 Td 53.472222 Tz (over ) Tj 1.613889 0 Td 50.636574 Tz (standard ) Tj 2.819444 0 Td 54.282407 Tz (methods. ) Tj 2.955556 0 Td 51.851852 Tz (Accordingly, ) Tj 51.428571 0 0 51.428571 0 2413.93253 Tm 25.277778 0 Td 49.259259 Tz (there ) Tj 1.652778 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 56.712963 Tz (need ) Tj 1.536111 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 51.446759 Tz (systems, ) Tj 2.663889 0 Td 54.6875 Tz (methods, ) Tj 2.8 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 53.567538 Tz (computer-readable ) Tj 51.428571 0 0 51.428571 0 2373.446602 Tm 25.297222 0 Td 59.62963 Tz (media ) Tj 2.002778 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 49.691358 Tz (detecting ) Tj 2.877778 0 Td 59.548611 Tz (glaucoma ) Tj 3.072222 0 Td 60.493827 Tz (and ) Tj 1.302778 0 Td 49.907407 Tz (other ) Tj 1.691667 0 Td 44.444444 Tz (retinal ) Tj 2.080556 0 Td 50.968013 Tz (pathologies ) Tj 51.428571 0 0 51.428571 0 2331.420307 Tm 25.277778 0 Td 46.990741 Tz (that ) Tj 1.225 0 Td 54.444444 Tz (outperform ) Tj 3.422222 0 Td 52.662037 Tz (both ) Tj 1.419444 0 Td 48.251029 Tz (currently ) Tj 2.741667 0 Td 53.796296 Tz (technology ) Tj 3.344444 0 Td 60.493827 Tz (and ) Tj 1.225 0 Td 70.216049 Tz (FFA ) Tj 1.380556 0 Td 59.41358 Tz (and ) Tj 1.186111 0 Td 86.419753 Tz (WFA ) Tj 51.428571 0 0 51.428571 0 2293 Tm 25.297222 0 Td 46.450617 Tz (analysis. ) Tj 51.428571 0 0 51.428571 0 2247.712546 Tm 26.036111 0 Td 51.851852 Tz (Likewise, ) Tj 2.955556 0 Td 48.611111 Tz (detection ) Tj 2.761111 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 55.902778 Tz (glaucomatous ) Tj 4.161111 0 Td 51.262626 Tz (progression ) Tj 3.5 0 Td 40.509259 Tz (is ) Tj 0.622222 0 Td 41.724537 Tz (critical ) Tj 51.428571 0 0 51.428571 0 2207.6 Tm 25.297222 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 53.796296 Tz (monitoring ) Tj 3.383333 0 Td 59.548611 Tz (glaucoma ) Tj 3.052778 0 Td 46.585648 Tz (patients ) Tj 2.430556 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 51.851852 Tz (preventing ) Tj 3.305556 0 Td 45.640432 Tz (irreversible ) Tj 51.428571 0 0 51.428571 0 2165.241335 Tm 25.297222 0 Td 49.151235 Tz (vision ) Tj 2.119444 0 Td 42.12963 Tz (loss. ) Tj 1.575 0 Td 57.118056 Tz (Although ) Tj 3.072222 0 Td 55.812757 Tz (measuring ) Tj 3.344444 0 Td 47.530864 Tz (visual ) Tj 2.061111 0 Td 42.12963 Tz (field ) Tj 1.594444 0 Td 46.180556 Tz (loss ) Tj 1.419444 0 Td 54.166667 Tz (through ) Tj 51.428571 0 0 51.428571 0 2121.340528 Tm 25.316667 0 Td 51.041667 Tz (standard ) Tj 2.586111 0 Td 55.812757 Tz (automated ) Tj 3.169444 0 Td 51.851852 Tz (perimetry ) Tj 2.975 0 Td 59.62963 Tz (\(SAP\) ) Tj 1.944444 0 Td 52.932099 Tz (has ) Tj 1.108333 0 Td 56.712963 Tz (been ) Tj 1.536111 0 Td 54.012346 Tz (widely ) Tj 2.1 0 Td 55.092593 Tz (used ) Tj 1.458333 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 2083.226792 Tm 25.297222 0 Td 53.148148 Tz (diagnosing ) Tj 3.305556 0 Td 56.17284 Tz (glaucomatous ) Tj 4.180556 0 Td 49.691358 Tz (progression, ) Tj 3.733333 0 Td 34.027778 Tz (it ) Tj 0.505556 0 Td 54.012346 Tz (has ) Tj 1.108333 0 Td 57.523148 Tz (been ) Tj 1.516667 0 Td 62.222222 Tz (shown ) Tj 2.022222 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 2040.293839 Tm 25.316667 0 Td 45.37037 Tz (structural ) Tj 2.858333 0 Td 55.555556 Tz (changes ) Tj 2.488889 0 Td 43.75 Tz (in ) Tj 0.661111 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 53.148148 Tz (nerve ) Tj 1.691667 0 Td 49.259259 Tz (fiberlayer ) Tj 3.072222 0 Td 68.055556 Tz (may ) Tj 1.341667 0 Td 54.62963 Tz (precede ) Tj 51.428571 0 0 51.428571 0 1996.647821 Tm 25.297222 0 Td 48.935185 Tz (functional ) Tj 3.091667 0 Td 55.555556 Tz (changes ) Tj 2.508333 0 Td 51.851852 Tz (obtained ) Tj 2.644444 0 Td 58.333333 Tz (by ) Tj 0.855556 0 Td 59.143519 Tz (SAP. ) Tj 1.575 0 Td 58.333333 Tz (Glaucomatous ) Tj 4.355556 0 Td 57.87037 Tz (progres ) Tj 40 0 0 40 0 1961 Tm 32.55 0 Td 63.541667 Tz (sion ) Tj 1.9 0 Td 47.916667 Tz (is ) Tj 0.925 0 Td 61.458333 Tz (also ) Tj 1.8 0 Td 84.166667 Tz (known ) Tj 2.875 0 Td 60.416667 Tz (to ) Tj 1.05 0 Td 75 Tz (be ) Tj 1.225 0 Td 54.62963 Tz (difficult ) Tj 3.3 0 Td 56.25 Tz (to ) Tj 1.05 0 Td 58.012821 Tz (differentiate ) Tj 4.85 0 Td 75 Tz (from ) Tj 2.15 0 Td 55.208333 Tz (test ) Tj 51.428571 0 0 51.428571 0 1915.762142 Tm 25.297222 0 Td 42.669753 Tz (variability. ) Tj 3.325 0 Td 52.391975 Tz (Accordingly, ) Tj 4.044444 0 Td 48.611111 Tz (there ) Tj 1.711111 0 Td 54.62963 Tz (remains ) Tj 2.566667 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 56.712963 Tz (need ) Tj 1.613889 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 51.041667 Tz (systems, ) Tj 51.428571 0 0 51.428571 0 1874.725537 Tm 25.297222 0 Td 55.092593 Tz (methods, ) Tj 2.8 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 53.376906 Tz (computer-readable ) Tj 5.638889 0 Td 58.981481 Tz (media ) Tj 1.944444 0 Td 47.530864 Tz (for ) Tj 1.011111 0 Td 49.259259 Tz (predicting ) Tj 3.111111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 68.055556 Tz (pro ) Tj 51.428571 0 0 51.428571 0 1833.290323 Tm 25.297222 0 Td 50.231481 Tz (gression ) Tj 2.605556 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 44.444444 Tz (retinal ) Tj 2.022222 0 Td 50.968013 Tz (pathologies ) Tj 3.577778 0 Td 54.282407 Tz (such ) Tj 1.477778 0 Td 51.851852 Tz (as ) Tj 0.797222 0 Td 55.452675 Tz (glaucoma. ) Tj 38.571429 0 0 38.571429 0 1757 Tm 38.344444 0 Td 117.283951 Tz (SUMMARY ) Tj 5.159259 0 Td 101.54321 Tz (OF ) Tj 1.425926 0 Td 106.584362 Tz (THE ) Tj 2.22963 0 Td 97.942387 Tz (INVENTION ) Tj 51.428571 0 0 51.428571 0 1669.401258 Tm 26.016667 0 Td 68.055556 Tz (One ) Tj 1.380556 0 Td 50.771605 Tz (aspect ) Tj 1.963889 0 Td 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(slopes; ) Tj 2.294444 0 Td 51.388889 Tz (thereby ) Tj 2.430556 0 Td 49.331276 Tz (detecting ) Tj 2.897222 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 43.518519 Tz (retinal ) Tj 51.428571 0 0 51.428571 0 1546.787097 Tm 6.358333 0 Td 53.652263 Tz (pathology ) Tj 3.091667 0 Td 46.990741 Tz (in ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.180556 Tz (Subject. ) Tj 51.428571 0 0 51.428571 0 1501.15978 Tm 7.097222 0 Td 52.662037 Tz (This ) Tj 1.555556 0 Td 51.311728 Tz (aspect ) Tj 2.138889 0 Td 54.012346 Tz (can ) Tj 1.263889 0 Td 56.712963 Tz (have ) Tj 1.652778 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 46.759259 Tz (variety ) Tj 2.294444 0 Td 55.092593 Tz (of ) Tj 0.855556 0 Td 56.712963 Tz (embodiments. ) Tj 4.433333 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 59.41358 Tz (one ) Tj 51.428571 0 0 51.428571 0 1459.643392 Tm 6.358333 0 Td 57.449495 Tz (embodiment, ) Tj 4.063889 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 59.41358 Tz (method ) Tj 2.430556 0 Td 47.530864 Tz (includes: ) Tj 2.877778 0 Td 49.691358 Tz (receiving ) Tj 2.916667 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 45.730453 Tz (plurality ) Tj 2.761111 0 Td 56.712963 Tz (of ) Tj 40 0 0 40 0 1423 Tm 8.175 0 Td 69.166667 Tz (one-dimensional ) Tj 6.7 0 Td 96.875 Tz (RNFL ) Tj 2.725 0 Td 63.541667 Tz (data ) Tj 1.9 0 Td 58.333333 Tz (sets ) Tj 1.825 0 Td 72.916667 Tz (of ) Tj 1.15 0 Td 68.888889 Tz (one-dimensional ) Tj 6.625 0 Td 64.583333 Tz (data ) Tj 51.428571 0 0 51.428571 0 1377.72449 Tm 6.358333 0 Td 46.296296 Tz (points, ) Tj 2.333333 0 Td 55.902778 Tz (each ) Tj 1.730556 0 Td 53.796296 Tz (one-dimensional ) Tj 5.25 0 Td 51.041667 Tz (data ) Tj 1.575 0 Td 51.203704 Tz (point ) Tj 1.905556 0 Td 50.231481 Tz (representing ) Tj 3.966667 0 Td 61.574074 Tz (an ) Tj 51.428571 0 0 51.428571 0 1335.305211 Tm 6.377778 0 Td 76.967593 Tz (RNFL ) Tj 2.061111 0 Td 49.331276 Tz (thickness ) Tj 2.897222 0 Td 51.203704 Tz (value ) Tj 1.75 0 Td 47.530864 Tz (for ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 46.180556 Tz (subject; ) Tj 2.411111 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 51.203704 Tz (converting ) Tj 3.266667 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 65.895062 Tz (plu ) Tj 51.428571 0 0 51.428571 0 1292.94491 Tm 6.358333 0 Td 42.12963 Tz (rality ) Tj 1.652778 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 53.796296 Tz (one-dimensional ) Tj 5.055556 0 Td 73.726852 Tz (RNFL ) Tj 1.925 0 Td 50.231481 Tz (data ) Tj 1.341667 0 Td 45.37037 Tz (sets ) Tj 1.244444 0 Td 46.180556 Tz (into ) Tj 1.263889 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 45.010288 Tz (plurality ) Tj 2.605556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 1252.795967 Tm 6.358333 0 Td 56.712963 Tz (pseudo ) Tj 2.216667 0 Td 54.012346 Tz (two-dimensional ) Tj 5.016667 0 Td 51.041667 Tz (data ) Tj 1.341667 0 Td 49.151235 Tz (points ) Tj 1.944444 0 Td 59.953704 Tz (by ) Tj 0.875 0 Td 49.200337 Tz (associating ) Tj 3.383333 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1208.759124 Tm 6.358333 0 Td 50.555556 Tz (point ) Tj 1.652778 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 53.796296 Tz (one-dimensional ) Tj 5.055556 0 Td 75.347222 Tz (RNFL ) Tj 1.963889 0 Td 51.041667 Tz (data ) Tj 1.380556 0 Td 45.37037 Tz (set ) Tj 0.972222 0 Td 52.662037 Tz (with ) Tj 1.438889 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 57.685185 Tz (corre ) Tj 51.428571 0 0 51.428571 0 1169.570033 Tm 6.377778 0 Td 55.497685 Tz (sponding ) Tj 2.838889 0 Td 53.796296 Tz (index ) Tj 1.808333 0 Td 46.990741 Tz (value. ) Tj 51.428571 0 0 51.428571 0 1125.909677 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.322222 0 Td 53.796296 Tz (one-dimensional ) Tj 5.094444 0 Td 76.157407 Tz (RNFL ) Tj 2.041667 0 Td 49.421296 Tz (data ) Tj 1.419444 0 Td 44.290123 Tz (set ) Tj 0.991667 0 Td 55.092593 Tz (can ) Tj 1.205556 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 52.932099 Tz (generated ) Tj 3.052778 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 1085.386308 Tm 6.358333 0 Td 56.712963 Tz (an ) Tj 0.875 0 Td 56.481481 Tz (imaging ) Tj 2.527778 0 Td 48.611111 Tz (device. ) Tj 2.216667 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 56.481481 Tz (imaging ) Tj 2.547222 0 Td 51.851852 Tz (device ) Tj 2.022222 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 56.712963 Tz (be ) Tj 0.855556 0 Td 49.016204 Tz (selected ) Tj 2.527778 0 Td 58.333333 Tz (from ) Tj 51.428571 0 0 51.428571 0 1047.014528 Tm 6.338889 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 57.037037 Tz (group ) Tj 1.886111 0 Td 48.935185 Tz (consisting ) Tj 3.072222 0 Td 55.092593 Tz (of ) Tj 0.933333 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 53.877315 Tz (scanning ) Tj 2.722222 0 Td 46.666667 Tz (laser ) Tj 1.497222 0 Td 48.611111 Tz (polarimeter, ) Tj 3.655556 0 Td 56.712963 Tz (an ) Tj 0.855556 0 Td 55.902778 Tz (opti ) Tj 51.428571 0 0 51.428571 0 1003.459459 Tm 6.358333 0 Td 46.450617 Tz (cal ) Tj 1.186111 0 Td 54.73251 Tz (coherence ) Tj 3.266667 0 Td 55.740741 Tz (tomograph, ) Tj 3.675 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 53.148148 Tz (Heidelberg ) Tj 3.519444 0 Td 45.910494 Tz (retina ) Tj 1.963889 0 Td 72.916667 Tz (tomo ) Tj 51.428571 0 0 51.428571 0 966 Tm 6.358333 0 Td 50.231481 Tz (graph. ) Tj 51.428571 0 0 51.428571 0 919.298734 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.283333 0 Td 43.981481 Tz (fractal ) Tj 2.041667 0 Td 55.812757 Tz (dimension ) Tj 3.188889 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 56.712963 Tz (be ) Tj 0.855556 0 Td 49.259259 Tz (calculated ) Tj 3.130556 0 Td 51.851852 Tz (using ) Tj 1.730556 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 52.932099 Tz (technique ) Tj 51.428571 0 0 51.428571 0 879.384519 Tm 6.377778 0 Td 48.611111 Tz (selected ) Tj 2.547222 0 Td 57.523148 Tz (from ) Tj 1.594444 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 57.037037 Tz (group ) Tj 1.925 0 Td 48.935185 Tz (consisting ) Tj 3.169444 0 Td 53.472222 Tz (of ) Tj 0.991667 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 54.012346 Tz (box-counting ) Tj 4.083333 0 Td 60.763889 Tz (tech ) Tj 51.428571 0 0 51.428571 0 835.289855 Tm 6.358333 0 Td 54.444444 Tz (nique ) Tj 1.75 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 46.018519 Tz (fractional ) Tj 2.955556 0 Td 58.738426 Tz (Brownian ) Tj 3.033333 0 Td 55.632716 Tz (motion ) Tj 2.177778 0 Td 49.583333 Tz (technique. ) Tj 3.15 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 55.902778 Tz (frac ) Tj 51.428571 0 0 51.428571 0 794.04674 Tm 6.338889 0 Td 41.049383 Tz (tal ) Tj 0.913889 0 Td 56.17284 Tz (dimension ) Tj 3.208333 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 49.259259 Tz (calculated ) Tj 3.130556 0 Td 52.5 Tz (using ) Tj 1.730556 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 45.730453 Tz (plurality ) Tj 2.683333 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 59.953704 Tz (tech ) Tj 51.428571 0 0 51.428571 0 758 Tm 6.358333 0 Td 49.074074 Tz (niques. ) Tj 51.428571 0 0 51.428571 0 711.892989 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.244444 0 Td 44.907407 Tz (classification ) Tj 3.888889 0 Td 52.572016 Tz (algorithm ) Tj 2.975 0 Td 56.17284 Tz (can ) Tj 1.127778 0 Td 56.712963 Tz (be ) Tj 0.797222 0 Td 48.148148 Tz (trained ) Tj 2.138889 0 Td 53.292181 Tz (according ) Tj 2.955556 0 Td 48.611111 Tz (to ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 40 0 0 40 0 675 Tm 8.225 0 Td 73.809524 Tz (methods ) Tj 3.35 0 Td 66.203704 Tz (described ) Tj 3.8 0 Td 60.714286 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 628.424552 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.283333 0 Td 43.981481 Tz (retinal ) Tj 2.002778 0 Td 54.012346 Tz (pathology ) Tj 3.130556 0 Td 54.012346 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 48.611111 Tz (selected ) Tj 2.488889 0 Td 58.333333 Tz (from ) Tj 1.575 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 56.388889 Tz (group ) Tj 1.886111 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 588.636943 Tm 6.377778 0 Td 44.907407 Tz (sisting ) Tj 2.236111 0 Td 55.092593 Tz (of ) Tj 1.127778 0 Td 56.17284 Tz (glaucoma, ) Tj 3.402778 0 Td 56.018519 Tz (macular ) Tj 2.663889 0 Td 50.356125 Tz (degeneration, ) Tj 4.277778 0 Td 58.333333 Tz (and ) Tj 1.419444 0 Td 56.018519 Tz (macular ) Tj 40 0 0 40 0 550 Tm 8.175 0 Td 73.611111 Tz (edema. ) Tj 51.428571 0 0 51.428571 0 505.461916 Tm 7.097222 0 Td 57.407407 Tz (Another ) Tj 2.508333 0 Td 51.311728 Tz (aspect ) Tj 2.002778 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 49.691358 Tz (invention ) Tj 2.819444 0 Td 52.256944 Tz (provides ) Tj 2.644444 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 57.336182 Tz (computer-read ) Tj 51.428571 0 0 51.428571 0 461.597786 Tm 6.358333 0 Td 51.041667 Tz (able ) Tj 1.438889 0 Td 64.274691 Tz (medium ) Tj 2.547222 0 Td 61.574074 Tz (whose ) Tj 2.022222 0 Td 50.231481 Tz (contents ) Tj 2.605556 0 Td 54.444444 Tz (cause ) Tj 1.788889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 57.928241 Tz (computer ) Tj 2.916667 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 56.018519 Tz (perform ) Tj 2.547222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 422.209974 Tm 6.358333 0 Td 61.033951 Tz (method ) Tj 2.488889 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 49.331276 Tz (detecting ) Tj 2.955556 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 43.981481 Tz (retinal ) Tj 2.138889 0 Td 54.012346 Tz (pathology ) Tj 3.247222 0 Td 43.75 Tz (in ) Tj 0.836111 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 46.180556 Tz (subject. ) Tj 2.527778 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 380.005057 Tm 6.358333 0 Td 61.033951 Tz (method ) Tj 2.488889 0 Td 47.890947 Tz (includes: ) Tj 2.897222 0 Td 54.768519 Tz (performing ) Tj 3.597222 0 Td 43.981481 Tz (fractal ) Tj 2.138889 0 Td 48.611111 Tz (analysis ) Tj 2.644444 0 Td 59.953704 Tz (on ) Tj 1.011111 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 57.79321 Tz (pseudo ) Tj 51.428571 0 0 51.428571 0 336.029126 Tm 6.338889 0 Td 54.444444 Tz (two-dimensional ) Tj 5.113889 0 Td 75.347222 Tz (RNFL ) Tj 1.963889 0 Td 50.231481 Tz (data ) Tj 1.4 0 Td 43.209877 Tz (set ) Tj 0.933333 0 Td 49.691358 Tz (for ) Tj 1.011111 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 49.074074 Tz (subject ) Tj 2.216667 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 47.890947 Tz (calculate ) Tj 2.741667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 297.287918 Tm 6.358333 0 Td 45.37037 Tz (plurality ) Tj 2.819444 0 Td 56.712963 Tz (of ) Tj 0.972222 0 Td 43.055556 Tz (fractal ) Tj 2.177778 0 Td 53.030303 Tz (dimensions; ) Tj 3.869444 0 Td 48.316498 Tz (calculating ) Tj 3.519444 0 Td 58.333333 Tz (a ) Tj 0.680556 0 Td 45.730453 Tz (plurality ) Tj 2.838889 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 253.201474 Tm 6.377778 0 Td 49.691358 Tz (slopes ) Tj 1.963889 0 Td 57.87037 Tz (between ) Tj 2.644444 0 Td 55.092593 Tz (each ) Tj 1.536111 0 Td 43.518519 Tz (fractal ) Tj 2.041667 0 Td 53.148148 Tz (dimension; ) Tj 3.402778 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 53.472222 Tz (applying ) Tj 2.741667 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 55.902778 Tz (clas ) Tj 51.428571 0 0 51.428571 0 214.677071 Tm 6.377778 0 Td 44.074074 Tz (sification ) Tj 2.780556 0 Td 52.572016 Tz (algorithm ) Tj 3.013889 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 48.611111 Tz (the ) Tj 1.011111 0 Td 45.730453 Tz (plurality ) Tj 2.644444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 47.222222 Tz (slopes; ) Tj 2.158333 0 Td 51.851852 Tz (thereby ) Tj 2.352778 0 Td 54.552469 Tz (detect ) Tj 51.428571 0 0 51.428571 0 173.316239 Tm 6.358333 0 Td 50.771605 Tz (ing ) Tj 1.108333 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 43.518519 Tz (retinal ) Tj 2.002778 0 Td 54.012346 Tz (pathology ) Tj 3.111111 0 Td 46.990741 Tz (in ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.180556 Tz (Subject. ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.775 0 Td 77.777778 Tz (4 ) Tj 51.428571 0 0 51.428571 0 2916.323077 Tm 26.036111 0 Td 38.888889 Tz (Still ) Tj 1.361111 0 Td 53.240741 Tz (another ) Tj 2.372222 0 Td 51.311728 Tz (aspect ) Tj 2.002778 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 49.691358 Tz (invention ) Tj 2.877778 0 Td 51.446759 Tz (provides ) Tj 2.663889 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 55.092593 Tz (system ) Tj 2.216667 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 2876.681265 Tm 25.297222 0 Td 49.331276 Tz (detecting ) Tj 2.819444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 43.981481 Tz (retinal ) Tj 2.041667 0 Td 50.231481 Tz (pathology. ) Tj 3.188889 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 55.632716 Tz (system ) Tj 2.216667 0 Td 47.890947 Tz (includes: ) Tj 2.761111 0 Td 58.333333 Tz (an ) Tj 0.913889 0 Td 69.675926 Tz (imag ) Tj 51.428571 0 0 51.428571 0 2833.571776 Tm 25.297222 0 Td 50.771605 Tz (ing ) Tj 1.108333 0 Td 51.851852 Tz (device ) Tj 2.022222 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 57.613169 Tz (computing ) Tj 3.266667 0 Td 48.611111 Tz (device. ) Tj 2.216667 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 57.613169 Tz (computing ) Tj 3.266667 0 Td 52.391975 Tz (device ) Tj 2.041667 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2794.422111 Tm 25.297222 0 Td 51.851852 Tz (configured ) Tj 3.441667 0 Td 45.37037 Tz (to ) Tj 0.894444 0 Td 57.613169 Tz (implement ) Tj 3.402778 0 Td 58.333333 Tz (a ) Tj 0.7 0 Td 59.953704 Tz (method ) Tj 2.469444 0 Td 48.935185 Tz (including: ) Tj 3.286111 0 Td 54.444444 Tz (performing ) Tj 51.428571 0 0 51.428571 0 2749.216282 Tm 25.297222 0 Td 43.981481 Tz (fractal ) Tj 2.002778 0 Td 49.421296 Tz (analysis ) Tj 2.527778 0 Td 61.574074 Tz (on ) Tj 0.913889 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 57.253086 Tz (pseudo ) Tj 2.255556 0 Td 54.012346 Tz (two-dimensional ) Tj 5.094444 0 Td 76.157407 Tz (RNFL ) Tj 2.002778 0 Td 49.421296 Tz (data ) Tj 1.4 0 Td 44.290123 Tz (set ) Tj 51.428571 0 0 51.428571 0 2707.295567 Tm 25.297222 0 Td 49.691358 Tz (for ) Tj 1.05 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 49.537037 Tz (subject ) Tj 2.236111 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 48.251029 Tz (calculate ) Tj 2.761111 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 45.37037 Tz (plurality ) Tj 2.663889 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 43.518519 Tz (fractal ) Tj 2.041667 0 Td 52.441077 Tz (dimensions: ) Tj 51.428571 0 0 51.428571 0 2667.692308 Tm 25.297222 0 Td 48.316498 Tz (calculating ) Tj 3.344444 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 45.730453 Tz (plurality ) Tj 2.644444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.231481 Tz (slopes ) Tj 2.002778 0 Td 57.87037 Tz (between ) Tj 2.586111 0 Td 55.092593 Tz (each ) Tj 1.516667 0 Td 43.981481 Tz (fractal ) Tj 2.022222 0 Td 68.703704 Tz (dimen ) Tj 51.428571 0 0 51.428571 0 2625.965728 Tm 25.316667 0 Td 45.37037 Tz (sion; ) Tj 1.594444 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 53.877315 Tz (applying ) Tj 2.761111 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 44.907407 Tz (classification ) Tj 3.986111 0 Td 51.851852 Tz (algorithm ) Tj 2.994444 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 46.090535 Tz (plurality ) Tj 51.428571 0 0 51.428571 0 2586.913043 Tm 25.297222 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 47.222222 Tz (slopes. ) Tj 51.428571 0 0 51.428571 0 2541.298969 Tm 26.016667 0 Td 55.092593 Tz (Yet ) Tj 1.186111 0 Td 53.240741 Tz (another ) Tj 2.391667 0 Td 51.311728 Tz (aspect ) Tj 2.041667 0 Td 61.574074 Tz (of ) Tj 0.836111 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 50.05144 Tz (invention ) Tj 2.916667 0 Td 51.851852 Tz (provides ) Tj 2.722222 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 59.41358 Tz (method ) Tj 2.333333 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 2501.81 Tm 25.297222 0 Td 49.259259 Tz (predicting ) Tj 3.227778 0 Td 51.262626 Tz (progression ) Tj 3.694444 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 43.981481 Tz (retinal ) Tj 2.138889 0 Td 50.231481 Tz (pathology. ) Tj 3.286111 0 Td 64.814815 Tz (The ) Tj 1.477778 0 Td 59.953704 Tz (method ) Tj 51.428571 0 0 51.428571 0 2458.226506 Tm 25.297222 0 Td 48.251029 Tz (includes: ) Tj 2.8 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 45.37037 Tz (plurality ) Tj 2.663889 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 56.712963 Tz (pseudo ) Tj 2.197222 0 Td 54.444444 Tz (two-dimensional ) Tj 5.094444 0 Td 50.231481 Tz (data ) Tj 1.380556 0 Td 44.560185 Tz (sets ) Tj 51.428571 0 0 51.428571 0 2416.072956 Tm 25.297222 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 53.796296 Tz (one-dimensional ) Tj 5.211111 0 Td 49.421296 Tz (data ) Tj 1.536111 0 Td 46.296296 Tz (points, ) Tj 2.294444 0 Td 55.092593 Tz (each ) Tj 1.672222 0 Td 57.253086 Tz (pseudo ) Tj 2.391667 0 Td 63.014403 Tz (two-dimen ) Tj 51.428571 0 0 51.428571 0 2375.623116 Tm 25.316667 0 Td 47.530864 Tz (sional ) Tj 1.963889 0 Td 49.421296 Tz (data ) Tj 1.419444 0 Td 50.555556 Tz (point ) Tj 1.769444 0 Td 49.421296 Tz (representing ) Tj 3.830556 0 Td 76.157407 Tz (RNFL ) Tj 2.041667 0 Td 50.05144 Tz (thickness ) Tj 2.994444 0 Td 49.691358 Tz (values ) Tj 2.041667 0 Td 47.530864 Tz (for ) Tj 1.069444 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2335.194271 Tm 25.316667 0 Td 49.074074 Tz (Subject ) Tj 2.255556 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 53.347578 Tz (corresponding ) Tj 4.394444 0 Td 53.148148 Tz (index ) Tj 1.866667 0 Td 49.691358 Tz (values ) Tj 2.041667 0 Td 47.530864 Tz (for ) Tj 1.069444 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 51.041667 Tz (data ) Tj 1.419444 0 Td 46.759259 Tz (points, ) Tj 51.428571 0 0 51.428571 0 2293.990315 Tm 25.297222 0 Td 53.06713 Tz (applying ) Tj 2.722222 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 50.106838 Tz (feature-based ) Tj 4.063889 0 Td 49.016204 Tz (analysis ) Tj 2.547222 0 Td 58.333333 Tz (on ) Tj 0.855556 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (data ) Tj 1.4 0 Td 40.509259 Tz (set; ) Tj 1.166667 0 Td 57.613169 Tz (combining ) Tj 51.428571 0 0 51.428571 0 2250.566845 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.341667 0 Td 44.444444 Tz (results ) Tj 2.313889 0 Td 57.523148 Tz (from ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.322222 0 Td 50.356125 Tz (feature-based ) Tj 4.336111 0 Td 48.611111 Tz (analysis ) Tj 2.761111 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 48.611111 Tz (subjects ) Tj 51.428571 0 0 51.428571 0 2210.893668 Tm 25.297222 0 Td 50 Tz (labeled ) Tj 2.236111 0 Td 50.231481 Tz (as ) Tj 0.758333 0 Td 51.557239 Tz (progressing ) Tj 3.538889 0 Td 46.990741 Tz (into ) Tj 1.263889 0 Td 58.333333 Tz (a ) Tj 0.466667 0 Td 52.146465 Tz (progressing ) Tj 3.597222 0 Td 49.421296 Tz (data ) Tj 1.361111 0 Td 39.699074 Tz (set; ) Tj 1.127778 0 Td 57.613169 Tz (combining ) Tj 51.428571 0 0 51.428571 0 2167.566845 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.341667 0 Td 44.444444 Tz (results ) Tj 2.313889 0 Td 57.523148 Tz (from ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 1.322222 0 Td 50.356125 Tz (feature-based ) Tj 4.336111 0 Td 48.611111 Tz (analysis ) Tj 2.761111 0 Td 48.611111 Tz (for ) Tj 1.263889 0 Td 48.611111 Tz (subjects ) Tj 51.428571 0 0 51.428571 0 2127.760494 Tm 25.297222 0 Td 50 Tz (labeled ) Tj 2.313889 0 Td 51.851852 Tz (as ) Tj 0.894444 0 Td 52.067901 Tz (non-progressing ) Tj 4.919444 0 Td 46.990741 Tz (into ) Tj 1.361111 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 52.067901 Tz (non-progressing ) Tj 4.938889 0 Td 50.231481 Tz (data ) Tj 1.419444 0 Td 41.319444 Tz (set; ) Tj 51.428571 0 0 51.428571 0 2084.889412 Tm 25.297222 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 53.472222 Tz (applying ) Tj 2.663889 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 46.450617 Tz (linear ) Tj 1.788889 0 Td 50.501543 Tz (discriminant ) Tj 3.752778 0 Td 49.826389 Tz (function ) Tj 2.527778 0 Td 46.990741 Tz (to ) Tj 0.680556 0 Td 50.771605 Tz (the ) Tj 1.011111 0 Td 51.557239 Tz (progressing ) Tj 51.428571 0 0 51.428571 0 2044.673267 Tm 25.297222 0 Td 51.041667 Tz (data ) Tj 1.438889 0 Td 45.37037 Tz (set ) Tj 0.972222 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 52.067901 Tz (non-progressing ) Tj 4.880556 0 Td 50.231481 Tz (data ) Tj 1.438889 0 Td 40.509259 Tz (set, ) Tj 1.147222 0 Td 52.314815 Tz (thereby ) Tj 2.391667 0 Td 47.800926 Tz (training ) Tj 2.488889 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2003.486874 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 3.966667 0 Td 52.211934 Tz (algorithm ) Tj 2.994444 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 49.259259 Tz (predicting ) Tj 3.130556 0 Td 50.968013 Tz (progression ) Tj 3.558333 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (reti ) Tj 51.428571 0 0 51.428571 0 1963.2 Tm 25.297222 0 Td 48.611111 Tz (nal ) Tj 1.069444 0 Td 50.231481 Tz (pathology. ) Tj 51.428571 0 0 51.428571 0 1916.989744 Tm 26.016667 0 Td 53.472222 Tz (This ) Tj 1.477778 0 Td 50.771605 Tz (aspect ) Tj 1.963889 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 49.691358 Tz (invention ) Tj 2.858333 0 Td 56.17284 Tz (can ) Tj 1.186111 0 Td 56.712963 Tz (have ) Tj 1.497222 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 46.296296 Tz (variety ) Tj 2.119444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 67.515432 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1877.188475 Tm 25.297222 0 Td 52.391975 Tz (ments. ) Tj 2.1 0 Td 58.333333 Tz (Each ) Tj 1.536111 0 Td 51.041667 Tz (data ) Tj 1.380556 0 Td 44.290123 Tz (set ) Tj 0.913889 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.836111 0 Td 50.87963 Tz (previously ) Tj 3.208333 0 Td 50 Tz (labeled ) Tj 2.197222 0 Td 51.851852 Tz (as ) Tj 0.758333 0 Td 51.557239 Tz (progressing ) Tj 51.428571 0 0 51.428571 0 1835.686177 Tm 25.297222 0 Td 53.472222 Tz (or ) Tj 0.894444 0 Td 50.636574 Tz (non-progressing. ) Tj 5.113889 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 59.953704 Tz (method ) Tj 2.411111 0 Td 55.092593 Tz (can ) Tj 1.283333 0 Td 50.925926 Tz (include ) Tj 2.391667 0 Td 48.611111 Tz (labeling ) Tj 2.605556 0 Td 55.902778 Tz (each ) Tj 51.428571 0 0 51.428571 0 1796.480935 Tm 25.297222 0 Td 51.041667 Tz (data ) Tj 1.438889 0 Td 45.37037 Tz (set ) Tj 0.991667 0 Td 48.611111 Tz (as ) Tj 0.816667 0 Td 51.557239 Tz (progressing ) Tj 3.616667 0 Td 53.472222 Tz (or ) Tj 0.836111 0 Td 50.434028 Tz (non-progressing. ) Tj 5.094444 0 Td 53.877315 Tz (Labeling ) Tj 2.780556 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 1752.10664 Tm 25.297222 0 Td 56.17284 Tz (performed ) Tj 3.208333 0 Td 59.953704 Tz (by ) Tj 0.894444 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 66.111111 Tz (human ) Tj 2.177778 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 53.877315 Tz (machine. ) Tj 51.428571 0 0 51.428571 0 1710.421456 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 43.981481 Tz (retinal ) Tj 2.002778 0 Td 54.012346 Tz (pathology ) Tj 3.130556 0 Td 54.012346 Tz (can ) Tj 1.127778 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 48.611111 Tz (selected ) Tj 2.488889 0 Td 58.333333 Tz (from ) Tj 1.555556 0 Td 51.851852 Tz (the ) Tj 1.069444 0 Td 56.388889 Tz (group ) Tj 1.886111 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 1670.632653 Tm 25.316667 0 Td 44.907407 Tz (sisting ) Tj 2.236111 0 Td 55.092593 Tz (of ) Tj 1.127778 0 Td 55.812757 Tz (glaucoma, ) Tj 3.402778 0 Td 56.018519 Tz (macular ) Tj 2.663889 0 Td 50.356125 Tz (degeneration, ) Tj 4.277778 0 Td 58.333333 Tz (and ) Tj 1.419444 0 Td 56.018519 Tz (macular ) Tj 41.428571 0 0 41.428571 0 1631 Tm 31.403448 0 Td 71.072797 Tz (edema. ) Tj 51.428571 0 0 51.428571 0 1584.775726 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 59.953704 Tz (method ) Tj 2.430556 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 47.685185 Tz (further ) Tj 2.236111 0 Td 47.800926 Tz (include: ) Tj 2.605556 0 Td 48.971193 Tz (receiving ) Tj 2.916667 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 45.730453 Tz (plurality ) Tj 2.722222 0 Td 59.953704 Tz (of ) Tj 40 0 0 40 0 1548 Tm 32.525 0 Td 69.166667 Tz (one-dimensional ) Tj 6.7 0 Td 95.833333 Tz (RNFL ) Tj 2.725 0 Td 63.541667 Tz (data ) Tj 1.9 0 Td 58.333333 Tz (sets ) Tj 1.825 0 Td 70.833333 Tz (of ) Tj 1.15 0 Td 68.888889 Tz (one-dimensional ) Tj 6.625 0 Td 64.583333 Tz (data ) Tj 51.428571 0 0 51.428571 0 1502.728553 Tm 25.297222 0 Td 45.833333 Tz (points, ) Tj 2.333333 0 Td 55.902778 Tz (each ) Tj 1.730556 0 Td 53.796296 Tz (one-dimensional ) Tj 5.25 0 Td 50.231481 Tz (data ) Tj 1.575 0 Td 51.203704 Tz (point ) Tj 1.905556 0 Td 50.231481 Tz (representing ) Tj 3.966667 0 Td 59.953704 Tz (an ) Tj 51.428571 0 0 51.428571 0 1460.266332 Tm 25.316667 0 Td 76.967593 Tz (RNFL ) Tj 2.080556 0 Td 49.331276 Tz (thickness ) Tj 2.916667 0 Td 51.203704 Tz (value ) Tj 1.75 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 49.537037 Tz (subject ) Tj 2.275 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 50.87963 Tz (converting ) Tj 3.286111 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 65.895062 Tz (plu ) Tj 51.428571 0 0 51.428571 0 1416.940263 Tm 25.297222 0 Td 42.12963 Tz (rality ) Tj 1.652778 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 53.796296 Tz (one-dimensional ) Tj 5.036111 0 Td 74.537037 Tz (RNFL ) Tj 1.944444 0 Td 50.231481 Tz (data ) Tj 1.341667 0 Td 45.37037 Tz (sets ) Tj 1.225 0 Td 46.990741 Tz (into ) Tj 1.283333 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 45.010288 Tz (plurality ) Tj 2.605556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 1377.791469 Tm 25.297222 0 Td 56.712963 Tz (pseudo ) Tj 2.197222 0 Td 54.228395 Tz (two-dimensional ) Tj 5.036111 0 Td 51.041667 Tz (data ) Tj 1.341667 0 Td 49.151235 Tz (points ) Tj 1.944444 0 Td 59.953704 Tz (by ) Tj 0.875 0 Td 49.200337 Tz (associating ) Tj 3.383333 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1332.741463 Tm 25.297222 0 Td 49.259259 Tz (point ) Tj 1.652778 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 53.796296 Tz (one-dimensional ) Tj 5.055556 0 Td 75.347222 Tz (RNFL ) Tj 1.963889 0 Td 51.041667 Tz (data ) Tj 1.380556 0 Td 45.37037 Tz (set ) Tj 0.952778 0 Td 53.472222 Tz (with ) Tj 1.458333 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 57.685185 Tz (corre ) Tj 51.428571 0 0 51.428571 0 1293.721863 Tm 25.316667 0 Td 55.092593 Tz (sponding ) Tj 3.052778 0 Td 53.796296 Tz (index ) Tj 2.041667 0 Td 46.450617 Tz (value. ) Tj 2.1 0 Td 62.654321 Tz (The ) Tj 1.516667 0 Td 45.730453 Tz (plurality ) Tj 2.897222 0 Td 56.712963 Tz (of ) Tj 1.011111 0 Td 53.580247 Tz (one-dimensional ) Tj 51.428571 0 0 51.428571 0 1252.06087 Tm 25.316667 0 Td 76.157407 Tz (RNFL ) Tj 2.022222 0 Td 51.041667 Tz (data ) Tj 1.4 0 Td 44.560185 Tz (sets ) Tj 1.263889 0 Td 55.092593 Tz (can ) Tj 1.186111 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 53.292181 Tz (generated ) Tj 3.033333 0 Td 59.953704 Tz (by ) Tj 0.894444 0 Td 56.712963 Tz (an ) Tj 0.875 0 Td 56.944444 Tz (imaging ) Tj 2.566667 0 Td 48.611111 Tz (device. ) Tj 2.236111 0 Td 62.654321 Tz (The ) Tj 51.428571 0 0 51.428571 0 1211.526252 Tm 25.297222 0 Td 56.944444 Tz (imaging ) Tj 2.547222 0 Td 52.391975 Tz (device ) Tj 2.041667 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 61.574074 Tz (be ) Tj 0.894444 0 Td 48.206019 Tz (selected ) Tj 2.469444 0 Td 58.333333 Tz (from ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 55.740741 Tz (group ) Tj 1.847222 0 Td 49.259259 Tz (consisting ) Tj 3.111111 0 Td 55.092593 Tz (of ) Tj 51.428571 0 0 51.428571 0 1170.25641 Tm 25.297222 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 53.877315 Tz (scanning ) Tj 2.916667 0 Td 46.666667 Tz (laser ) Tj 1.691667 0 Td 48.611111 Tz (polarimeter, ) Tj 3.830556 0 Td 56.712963 Tz (an ) Tj 1.030556 0 Td 47.222222 Tz (optical ) Tj 2.333333 0 Td 54.372428 Tz (coherence ) Tj 3.247222 0 Td 72.916667 Tz (tomo ) Tj 51.428571 0 0 51.428571 0 1129.849315 Tm 25.297222 0 Td 50.771605 Tz (graph, ) Tj 2.002778 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 52.824074 Tz (Heidelberg ) Tj 3.363889 0 Td 45.910494 Tz (retina ) Tj 1.827778 0 Td 55.092593 Tz (tomograph. ) Tj 51.428571 0 0 51.428571 0 1084.593452 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.497222 0 Td 50.356125 Tz (feature-based ) Tj 4.277778 0 Td 52.572016 Tz (technique ) Tj 3.188889 0 Td 55.092593 Tz (can ) Tj 1.361111 0 Td 58.333333 Tz (be ) Tj 1.05 0 Td 49.016204 Tz (selected ) Tj 2.702778 0 Td 58.333333 Tz (from ) Tj 1.788889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1045.694611 Tm 25.297222 0 Td 56.388889 Tz (group ) Tj 1.827778 0 Td 49.259259 Tz (consisting ) Tj 3.091667 0 Td 55.092593 Tz (of ) Tj 0.952778 0 Td 43.518519 Tz (fractal ) Tj 1.944444 0 Td 49.016204 Tz (analysis ) Tj 2.508333 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 44.560185 Tz (fast ) Tj 1.225 0 Td 50 Tz (Fourier ) Tj 2.197222 0 Td 46.8107 Tz (analysis. ) Tj 51.428571 0 0 51.428571 0 1004.855769 Tm 25.316667 0 Td 47.222222 Tz (Fractal ) Tj 2.158333 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 55.092593 Tz (can ) Tj 1.166667 0 Td 58.333333 Tz (be ) Tj 0.836111 0 Td 56.532922 Tz (performed ) Tj 3.208333 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 52.572016 Tz (technique ) Tj 2.994444 0 Td 49.016204 Tz (selected ) Tj 51.428571 0 0 51.428571 0 963.668682 Tm 25.297222 0 Td 58.333333 Tz (from ) Tj 1.536111 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 57.037037 Tz (group ) Tj 1.866667 0 Td 49.259259 Tz (consisting ) Tj 3.091667 0 Td 55.092593 Tz (of ) Tj 0.952778 0 Td 51.851852 Tz (a ) Tj 0.466667 0 Td 54.012346 Tz (box-counting ) Tj 4.025 0 Td 52.572016 Tz 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49.691358 Tz (the ) Tj 40 0 0 40 0 2252 Tm 8.225 0 Td 73.809524 Tz (methods ) Tj 3.35 0 Td 66.203704 Tz (described ) Tj 3.8 0 Td 60.714286 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 2204.424552 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.283333 0 Td 43.981481 Tz (retinal ) Tj 2.002778 0 Td 54.012346 Tz (pathology ) Tj 3.130556 0 Td 54.012346 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 48.611111 Tz (selected ) Tj 2.488889 0 Td 58.333333 Tz (from ) Tj 1.575 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 56.388889 Tz (group ) Tj 1.886111 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 2165.636943 Tm 6.377778 0 Td 44.907407 Tz (sisting ) Tj 2.236111 0 Td 55.092593 Tz (of ) Tj 1.127778 0 Td 56.17284 Tz (glaucoma, ) Tj 3.402778 0 Td 56.018519 Tz (macular ) Tj 2.663889 0 Td 50.356125 Tz (degeneration, ) Tj 4.277778 0 Td 58.333333 Tz (and ) Tj 1.419444 0 Td 56.018519 Tz (macular ) Tj 40 0 0 40 0 2127 Tm 8.175 0 Td 73.611111 Tz (edema. ) Tj 51.428571 0 0 51.428571 0 2082.461916 Tm 7.097222 0 Td 57.407407 Tz (Another ) Tj 2.508333 0 Td 51.311728 Tz (aspect ) Tj 2.002778 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 49.691358 Tz (invention ) Tj 2.819444 0 Td 52.256944 Tz (provides ) Tj 2.644444 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 57.336182 Tz (computer-read ) Tj 51.428571 0 0 51.428571 0 2038.597786 Tm 6.358333 0 Td 51.041667 Tz (able ) Tj 1.438889 0 Td 64.274691 Tz (medium ) Tj 2.547222 0 Td 61.574074 Tz (whose ) Tj 2.022222 0 Td 50.231481 Tz (contents ) Tj 2.605556 0 Td 54.444444 Tz (cause ) Tj 1.788889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 57.928241 Tz (computer ) Tj 2.916667 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 56.018519 Tz (perform ) Tj 2.547222 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1998.655257 Tm 6.358333 0 Td 61.033951 Tz (method ) Tj 2.391667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 49.259259 Tz (predicting ) Tj 3.15 0 Td 51.262626 Tz (progression ) Tj 3.597222 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 44.444444 Tz (retinal ) Tj 2.041667 0 Td 54.012346 Tz (pathology ) Tj 3.130556 0 Td 45.37037 Tz (in ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1955.798517 Tm 6.377778 0 Td 45.775463 Tz (subject. ) Tj 2.488889 0 Td 64.814815 Tz (The ) Tj 1.458333 0 Td 60.493827 Tz (method ) Tj 2.469444 0 Td 48.251029 Tz (includes: ) Tj 2.897222 0 Td 55.092593 Tz (performing ) Tj 3.597222 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 50.605413 Tz (feature-based ) Tj 51.428571 0 0 51.428571 0 1913.205882 Tm 6.358333 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 61.574074 Tz (on ) Tj 0.913889 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 56.712963 Tz (pseudo ) Tj 2.236111 0 Td 54.012346 Tz (two-dimensional ) Tj 5.094444 0 Td 76.157407 Tz (RNFL ) Tj 2.002778 0 Td 49.421296 Tz (data ) Tj 1.380556 0 Td 44.290123 Tz (set ) Tj 0.972222 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1873.732685 Tm 6.377778 0 Td 49.074074 Tz (Subject ) Tj 2.236111 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 53.472222 Tz (applying ) Tj 2.722222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 45.138889 Tz (classification ) Tj 3.966667 0 Td 52.572016 Tz (algorithm ) Tj 3.052778 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 44.444444 Tz (results ) Tj 51.428571 0 0 51.428571 0 1833.211823 Tm 6.358333 0 Td 58.333333 Tz (of ) Tj 0.894444 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 50.106838 Tz (feature-based ) Tj 4.180556 0 Td 46.450617 Tz (analysis, ) Tj 2.819444 0 Td 51.851852 Tz (thereby ) Tj 2.508333 0 Td 48.971193 Tz (detecting ) Tj 2.936111 0 Td 49.259259 Tz (predicting ) Tj 51.428571 0 0 51.428571 0 1792.540412 Tm 6.358333 0 Td 51.262626 Tz (progression ) Tj 3.577778 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 53.652263 Tz (pathology ) Tj 3.130556 0 Td 43.75 Tz (in ) Tj 0.7 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.180556 Tz (Subject. ) Tj 51.428571 0 0 51.428571 0 1748.373868 Tm 7.097222 0 Td 54.012346 Tz (Yet ) Tj 1.166667 0 Td 52.777778 Tz (another ) Tj 2.372222 0 Td 51.311728 Tz (aspect ) Tj 2.061111 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 49.691358 Tz (invention ) Tj 2.897222 0 Td 52.256944 Tz (provides ) Tj 2.702778 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 55.092593 Tz (system ) Tj 2.216667 0 Td 48.611111 Tz (for ) Tj 51.428571 0 0 51.428571 0 1707.685298 Tm 6.358333 0 Td 49.691358 Tz (detecting ) Tj 2.819444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 43.981481 Tz (retinal ) Tj 2.041667 0 Td 50.231481 Tz (pathology. ) Tj 3.188889 0 Td 64.814815 Tz (The ) Tj 1.322222 0 Td 55.632716 Tz (system ) Tj 2.216667 0 Td 47.890947 Tz (includes: ) Tj 2.780556 0 Td 56.712963 Tz (an ) Tj 0.894444 0 Td 69.675926 Tz (imag ) Tj 51.428571 0 0 51.428571 0 1667.238434 Tm 6.358333 0 Td 50.771605 Tz (ing ) Tj 1.088889 0 Td 51.851852 Tz (device ) Tj 1.963889 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 51.851852 Tz (a ) Tj 0.447222 0 Td 57.613169 Tz (computing ) Tj 3.266667 0 Td 51.851852 Tz (device ) Tj 1.983333 0 Td 52.175926 Tz (configured ) Tj 3.247222 0 Td 45.37037 Tz (to ) Tj 0.7 0 Td 59.62963 Tz (implementa ) Tj 52.857143 0 0 52.857143 0 1623.267315 Tm 6.186486 0 Td 59.384384 Tz (method ) Tj 2.345946 0 Td 46.981982 Tz (including: ) Tj 3.045946 0 Td 53.603604 Tz (performing ) Tj 3.386486 0 Td 50.45045 Tz (a ) Tj 0.52973 0 Td 48.752599 Tz (feature-based ) Tj 3.991892 0 Td 47.297297 Tz (analysis ) Tj 2.478378 0 Td 58.333333 Tz (on ) Tj 0.908108 0 Td 53.603604 Tz (a ) Tj 51.428571 0 0 51.428571 0 1580.167742 Tm 6.358333 0 Td 56.712963 Tz (pseudo ) Tj 2.372222 0 Td 53.796296 Tz (two-dimensional ) Tj 5.191667 0 Td 75.347222 Tz (RNFL ) Tj 2.119444 0 Td 49.421296 Tz (data ) Tj 1.477778 0 Td 45.37037 Tz (set ) Tj 1.088889 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 48.611111 Tz (subject ) Tj 2.313889 0 Td 46.990741 Tz (to ) Tj 51.428571 0 0 51.428571 0 1538.653009 Tm 6.358333 0 Td 47.890947 Tz (calculate ) Tj 2.858333 0 Td 58.333333 Tz (a ) Tj 0.641667 0 Td 45.730453 Tz (plurality ) Tj 2.780556 0 Td 58.333333 Tz (of ) Tj 0.913889 0 Td 43.518519 Tz (fractal ) Tj 2.138889 0 Td 55.092593 Tz (dimensions ) Tj 3.616667 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 53.472222 Tz (applying ) Tj 2.858333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1495.452711 Tm 6.358333 0 Td 45.138889 Tz (classification ) Tj 4.083333 0 Td 51.851852 Tz (algorithm ) Tj 3.130556 0 Td 46.990741 Tz (to ) Tj 0.894444 0 Td 48.611111 Tz (the ) Tj 1.186111 0 Td 44.444444 Tz (results ) Tj 2.177778 0 Td 58.333333 Tz (of ) Tj 0.913889 0 Td 48.611111 Tz (the ) Tj 1.166667 0 Td 50.605413 Tz (feature-based ) Tj 51.428571 0 0 51.428571 0 1461 Tm 6.358333 0 Td 46.450617 Tz (analysis. ) Tj 38.571429 0 0 38.571429 0 1382 Tm 18.122222 0 Td 95.061728 Tz (FIGURES ) Tj 51.428571 0 0 51.428571 0 1294.16812 Tm 7.116667 0 Td 55.092593 Tz (For ) Tj 1.108333 0 Td 51.851852 Tz (a ) Tj 0.466667 0 Td 44.290123 Tz (fuller ) Tj 1.691667 0 Td 52.849003 Tz (understanding ) Tj 4.258333 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 48.611111 Tz (the ) Tj 1.011111 0 Td 50.231481 Tz (nature ) Tj 1.944444 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 50.462963 Tz (desired ) Tj 2.236111 0 Td 49.074074 Tz (objects ) Tj 51.428571 0 0 51.428571 0 1251.543641 Tm 6.358333 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 50.925926 Tz (present ) Tj 2.313889 0 Td 48.287037 Tz (invention, ) Tj 3.130556 0 Td 49.691358 Tz (reference ) Tj 2.897222 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 64.814815 Tz (made ) Tj 1.769444 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 52.211934 Tz (following ) Tj 51.428571 0 0 51.428571 0 1212.45953 Tm 6.358333 0 Td 48.206019 Tz (detailed ) Tj 2.683333 0 Td 48.316498 Tz (description ) Tj 3.538889 0 Td 52.5 Tz (taken ) Tj 1.963889 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 51.851852 Tz (conjunction ) Tj 3.811111 0 Td 52.662037 Tz (with ) Tj 1.633333 0 Td 49.691358 Tz (the ) Tj 1.263889 0 Td 46.990741 Tz (figure ) Tj 40 0 0 40 0 1174 Tm 8.15 0 Td 67.708333 Tz (wherein: ) Tj 51.428571 0 0 51.428571 0 1127.118644 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.536111 0 Td 48.611111 Tz (1 ) Tj 0.563889 0 Td 48.148148 Tz (depicts ) Tj 2.216667 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 59.953704 Tz (method ) Tj 2.352778 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 47.395833 Tz (training ) Tj 2.45 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 45.138889 Tz (classification ) Tj 3.966667 0 Td 63.194444 Tz (algo ) Tj 51.428571 0 0 51.428571 0 1087.106734 Tm 6.358333 0 Td 51.851852 Tz (rithm ) Tj 1.769444 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 49.151235 Tz (detect ) Tj 1.944444 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 43.518519 Tz (retinal ) Tj 2.041667 0 Td 53.652263 Tz (pathology ) Tj 3.15 0 Td 43.75 Tz (in ) Tj 0.758333 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 49.074074 Tz (subject ) Tj 2.236111 0 Td 53.652263 Tz (according ) Tj 3.091667 0 Td 46.990741 Tz (to ) Tj 48.571429 0 0 48.571429 0 1043 Tm 6.732353 0 Td 62.908497 Tz (one ) Tj 1.297059 0 Td 64.509804 Tz (embodiment ) Tj 4.076471 0 Td 60.04902 Tz (of ) Tj 0.782353 0 Td 54.901961 Tz (the ) Tj 1.173529 0 Td 50.784314 Tz (invention; ) Tj 51.428571 0 0 51.428571 0 1001.675607 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.536111 0 Td 74.537037 Tz (2A ) Tj 1.088889 0 Td 48.611111 Tz (depicts ) Tj 2.236111 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 47.800926 Tz (plot ) Tj 1.322222 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 54.012346 Tz (one-dimensional ) Tj 5.036111 0 Td 70 Tz (TSNIT ) Tj 2.313889 0 Td 76.157407 Tz (RNFL ) Tj 42.857143 0 0 42.857143 0 960 Tm 7.606667 0 Td 57.361111 Tz (Vectors; ) Tj 51.428571 0 0 51.428571 0 919.727735 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.497222 0 Td 69.675926 Tz (2B ) Tj 1.05 0 Td 48.148148 Tz (depicts ) Tj 2.216667 0 Td 51.851852 Tz (a ) Tj 0.505556 0 Td 47.800926 Tz (plot ) Tj 1.302778 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 56.712963 Tz (pseudo ) Tj 2.255556 0 Td 53.796296 Tz (two-dimensional ) Tj 5.016667 0 Td 69.351852 Tz (TSNIT ) Tj 48.571429 0 0 48.571429 0 877 Tm 6.732353 0 Td 48.72549 Tz (data; ) Tj 51.428571 0 0 51.428571 0 834.751669 Tm 7.116667 0 Td 57.037037 Tz (FIGS. ) Tj 1.963889 0 Td 74.537037 Tz (3A ) Tj 1.127778 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 71.296296 Tz (3B ) Tj 1.108333 0 Td 49.691358 Tz (depict ) Tj 2.022222 0 Td 43.981481 Tz (fractal ) Tj 2.1 0 Td 55.812757 Tz (dimension ) Tj 3.266667 0 Td 46.666667 Tz (plots ) Tj 1.652778 0 Td 50.771605 Tz (for ) Tj 1.108333 0 Td 59.41358 Tz (two ) Tj 51.428571 0 0 51.428571 0 800 Tm 6.377778 0 Td 46.450617 Tz (Subjects; ) Tj 51.428571 0 0 51.428571 0 752.503817 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.497222 0 Td 74.537037 Tz (4A ) Tj 1.088889 0 Td 48.611111 Tz (depicts ) Tj 2.236111 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 51.041667 Tz (area ) Tj 1.4 0 Td 56.388889 Tz (under ) Tj 1.847222 0 Td 49.016204 Tz (receiver ) Tj 2.508333 0 Td 50.771605 Tz (operating ) Tj 2.916667 0 Td 59.41358 Tz (charac ) Tj 51.428571 0 0 51.428571 0 712.167513 Tm 6.338889 0 Td 41.724537 Tz (teristic ) Tj 2.45 0 Td 69.907407 Tz (\(AUROC\) ) Tj 3.344444 0 Td 48.070988 Tz (calculations ) Tj 3.927778 0 Td 47.530864 Tz (for ) Tj 1.244444 0 Td 47.530864 Tz (principal ) Tj 3.013889 0 Td 58.333333 Tz (components ) Tj 51.428571 0 0 51.428571 0 669.364532 Tm 6.358333 0 Td 48.611111 Tz (analysis ) Tj 2.547222 0 Td 62.87037 Tz (\(PCA\) ) Tj 2.080556 0 Td 46.990741 Tz (features ) Tj 2.547222 0 Td 47.314815 Tz (1-25; ) Tj 51.428571 0 0 51.428571 0 628.904325 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.575 0 Td 69.675926 Tz (4B ) Tj 1.127778 0 Td 48.611111 Tz (depicts ) Tj 2.313889 0 Td 49.331276 Tz (detection ) Tj 2.916667 0 Td 43.981481 Tz (ability ) Tj 2.119444 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 44.907407 Tz (classification ) Tj 4.044444 0 Td 62.384259 Tz (algo ) Tj 51.428571 0 0 51.428571 0 585.40566 Tm 6.358333 0 Td 51.311728 Tz (rithms ) Tj 1.983333 0 Td 48.611111 Tz (trained ) Tj 2.138889 0 Td 53.652263 Tz (according ) Tj 3.033333 0 Td 45.37037 Tz (to ) Tj 0.680556 0 Td 59.41358 Tz (one ) Tj 1.186111 0 Td 60.925926 Tz (embodiment ) Tj 3.772222 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 47.962963 Tz (invention; ) Tj 51.428571 0 0 51.428571 0 545.696822 Tm 7.116667 0 Td 59.62963 Tz (FIG.5 ) Tj 1.944444 0 Td 48.148148 Tz (depicts ) Tj 2.138889 0 Td 58.333333 Tz (a ) Tj 0.447222 0 Td 43.981481 Tz (retinal ) Tj 1.963889 0 Td 54.012346 Tz (pathology ) Tj 3.052778 0 Td 49.331276 Tz (detection ) Tj 2.741667 0 Td 52.932099 Tz (and/or ) Tj 2.002778 0 Td 57.407407 Tz (progres ) Tj 51.428571 0 0 51.428571 0 504.936353 Tm 6.377778 0 Td 50.231481 Tz (sion ) Tj 1.4 0 Td 49.259259 Tz (prediction ) Tj 3.188889 0 Td 54.552469 Tz (system ) Tj 2.177778 0 Td 53.652263 Tz (according ) Tj 3.072222 0 Td 48.611111 Tz (to ) Tj 0.797222 0 Td 59.41358 Tz (one ) Tj 1.263889 0 Td 60.925926 Tz (embodiment ) Tj 3.869444 0 Td 55.092593 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 48.571429 0 0 48.571429 0 461 Tm 6.732353 0 Td 50.784314 Tz (invention; ) Tj 51.428571 0 0 51.428571 0 421.969543 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.477778 0 Td 58.333333 Tz (6 ) Tj 0.486111 0 Td 48.148148 Tz (depicts ) Tj 2.177778 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 59.41358 Tz (method ) Tj 2.275 0 Td 48.611111 Tz (for ) Tj 0.972222 0 Td 49.331276 Tz (detecting ) Tj 2.8 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 43.518519 Tz (retinal ) Tj 1.944444 0 Td 54.012346 Tz (pathology ) Tj 3.072222 0 Td 48.611111 Tz (in ) Tj 51.428571 0 0 51.428571 0 378.645914 Tm 6.358333 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 49.537037 Tz (subject ) Tj 2.236111 0 Td 53.292181 Tz (according ) Tj 3.052778 0 Td 46.990741 Tz (to ) Tj 0.758333 0 Td 58.333333 Tz (one ) Tj 1.205556 0 Td 60.925926 Tz (embodiment ) Tj 3.869444 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 47.962963 Tz (invention; ) Tj 51.428571 0 0 51.428571 0 337.649418 Tm 7.116667 0 Td 57.037037 Tz (FIGS. ) Tj 1.925 0 Td 72.916667 Tz (7A ) Tj 1.030556 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 68.055556 Tz (7B ) Tj 1.030556 0 Td 49.151235 Tz (depict ) Tj 1.925 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 47.685185 Tz (further ) Tj 2.177778 0 Td 60.493827 Tz (method ) Tj 2.352778 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 48.611111 Tz (identifying ) Tj 3.344444 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 296.31 Tm 6.358333 0 Td 43.981481 Tz (retinal ) Tj 2.158333 0 Td 53.652263 Tz (pathology ) Tj 3.208333 0 Td 53.148148 Tz (using ) Tj 1.886111 0 Td 46.118234 Tz (multi-fractal ) Tj 3.927778 0 Td 47.800926 Tz (features ) Tj 2.605556 0 Td 57.523148 Tz (from ) Tj 1.730556 0 Td 46.296296 Tz (optical ) Tj 51.428571 0 0 51.428571 0 255.45481 Tm 6.358333 0 Td 54.73251 Tz (coherence ) Tj 3.111111 0 Td 56.271044 Tz (tomography; ) Tj 51.428571 0 0 51.428571 0 214.30303 Tm 7.116667 0 Td 54.282407 Tz (FIG. ) Tj 1.497222 0 Td 74.537037 Tz (8A ) Tj 1.069444 0 Td 48.611111 Tz (depicts ) Tj 2.255556 0 Td 79.938272 Tz (ROC ) Tj 1.594444 0 Td 51.851852 Tz (curves ) Tj 2.061111 0 Td 49.691358 Tz (for ) Tj 1.030556 0 Td 56.712963 Tz (examples ) Tj 2.897222 0 Td 48.881173 Tz (applications ) Tj 3.675 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 171.305211 Tm 6.338889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 59.953704 Tz (method ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 56.388889 Tz (FIGS. ) Tj 1.925 0 Td 74.537037 Tz (7A ) Tj 1.088889 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 69.675926 Tz (7B ) Tj 1.088889 0 Td 44.650206 Tz (utilizing ) Tj 2.605556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 52.10114 Tz (box-counting, ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.9 0 Td 69.369369 Tz (6 ) Tj 51.428571 0 0 51.428571 0 2914.538462 Tm 25.297222 0 Td 47.395833 Tz (multi-fractional ) Tj 4.938889 0 Td 58.738426 Tz (Brownian ) Tj 3.169444 0 Td 50.231481 Tz (technique, ) Tj 3.363889 0 Td 60.493827 Tz (and ) Tj 1.458333 0 Td 59.548611 Tz (combined ) Tj 3.188889 0 Td 74.537037 Tz (box ) Tj 51.428571 0 0 51.428571 0 2873.452632 Tm 25.297222 0 Td 53.06713 Tz (counting ) Tj 2.761111 0 Td 47.193287 Tz (multi-fractional ) Tj 4.725 0 Td 58.738426 Tz (Brownian ) Tj 2.994444 0 Td 50.555556 Tz (technique; ) Tj 51.428571 0 0 51.428571 0 2830.309252 Tm 26.036111 0 Td 55.092593 Tz (FIG. ) Tj 1.497222 0 Td 71.296296 Tz (8B ) Tj 1.069444 0 Td 48.148148 Tz (depicts ) Tj 2.255556 0 Td 79.938272 Tz (ROC ) Tj 1.594444 0 Td 51.851852 Tz (curves ) Tj 2.080556 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 56.712963 Tz (examples ) Tj 2.897222 0 Td 48.881173 Tz (applications ) Tj 3.694444 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 2785.311029 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 59.953704 Tz (method ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 56.388889 Tz (FIGS. ) Tj 1.925 0 Td 74.537037 Tz (7A ) Tj 1.088889 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 69.675926 Tz (7B ) Tj 1.069444 0 Td 45.010288 Tz (utilizing ) Tj 2.625 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 52.10114 Tz (box-counting, ) Tj 51.428571 0 0 51.428571 0 2740.538462 Tm 25.297222 0 Td 47.395833 Tz (multi-fractional ) Tj 4.938889 0 Td 58.738426 Tz (Brownian ) Tj 3.169444 0 Td 50.231481 Tz (technique, ) Tj 3.363889 0 Td 60.493827 Tz (and ) Tj 1.458333 0 Td 59.548611 Tz (combined ) Tj 3.188889 0 Td 74.537037 Tz (box ) Tj 51.428571 0 0 51.428571 0 2697.686061 Tm 25.297222 0 Td 53.06713 Tz (counting ) Tj 2.761111 0 Td 47.193287 Tz (multi-fractional ) Tj 4.763889 0 Td 58.738426 Tz (Brownian ) Tj 3.013889 0 Td 52.572016 Tz (technique ) Tj 3.013889 0 Td 50.231481 Tz (as ) Tj 0.816667 0 Td 51.041667 Tz (well ) Tj 1.438889 0 Td 51.851852 Tz (as ) Tj 0.836111 0 Td 47.530864 Tz (for ) Tj 51.428571 0 0 51.428571 0 2656.242673 Tm 25.297222 0 Td 48.905724 Tz (predictions ) Tj 3.344444 0 Td 56.388889 Tz (based ) Tj 1.827778 0 Td 61.574074 Tz (on ) Tj 0.913889 0 Td 45.775463 Tz (Inferior ) Tj 2.275 0 Td 53.472222 Tz (Average, ) Tj 2.741667 0 Td 52.256944 Tz (Superior ) Tj 2.605556 0 Td 53.472222 Tz (Average, ) Tj 2.683333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2609.991968 Tm 25.297222 0 Td 57.407407 Tz (Average ) Tj 2.547222 0 Td 54.73251 Tz (Thickness ) Tj 3.169444 0 Td 55.34188 Tz (measurements; ) Tj 51.428571 0 0 51.428571 0 2567.26162 Tm 26.036111 0 Td 57.037037 Tz (FIGS. ) Tj 1.944444 0 Td 76.157407 Tz (9A ) Tj 1.127778 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 71.296296 Tz (9B ) Tj 1.108333 0 Td 49.691358 Tz (depict ) Tj 1.963889 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 59.953704 Tz (method ) Tj 2.352778 0 Td 61.574074 Tz (of ) Tj 0.836111 0 Td 49.583333 Tz (predicting ) Tj 3.208333 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 66.975309 Tz (pro ) Tj 51.428571 0 0 51.428571 0 2525.247113 Tm 25.297222 0 Td 50.231481 Tz (gression ) Tj 2.605556 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 43.981481 Tz (retinal ) Tj 2.002778 0 Td 51.851852 Tz (pathology; ) Tj 51.428571 0 0 51.428571 0 2480.323246 Tm 26.036111 0 Td 55.092593 Tz (FIG. ) Tj 1.652778 0 Td 58.333333 Tz (10 ) Tj 0.972222 0 Td 52.662037 Tz (provides ) Tj 2.8 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 55.740741 Tz (comparison ) Tj 3.675 0 Td 59.953704 Tz (of ) Tj 0.952778 0 Td 77.777778 Tz (ROC ) Tj 1.691667 0 Td 52.391975 Tz (curves ) Tj 2.197222 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 43.75 Tz (fast ) Tj 51.428571 0 0 51.428571 0 2435.240373 Tm 25.316667 0 Td 50.925926 Tz (Fourier ) Tj 2.255556 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 53.472222 Tz (\(FFA\), ) Tj 2.080556 0 Td 51.419753 Tz (wavelet-Fourier ) Tj 4.725 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 61.574074 Tz (\(WFA\), ) Tj 2.333333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2391.878825 Tm 25.297222 0 Td 43.981481 Tz (fractal ) Tj 2.041667 0 Td 49.016204 Tz (analysis ) Tj 2.566667 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 44.907407 Tz (classification ) Tj 3.986111 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 50.968013 Tz (progressors ) Tj 3.597222 0 Td 43.209877 Tz (vs. ) Tj 1.030556 0 Td 72.376543 Tz (non ) Tj 51.428571 0 0 51.428571 0 2352.109705 Tm 25.297222 0 Td 48.881173 Tz (progressors; ) Tj 3.733333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2305.403141 Tm 26.036111 0 Td 55.092593 Tz (FIG. ) Tj 1.594444 0 Td 55.092593 Tz (11 ) Tj 0.875 0 Td 51.851852 Tz (provides ) Tj 2.702778 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 59.953704 Tz (method ) Tj 2.391667 0 Td 59.953704 Tz (1100 ) Tj 1.613889 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.331276 Tz (detecting ) Tj 2.858333 0 Td 52.932099 Tz (and/or ) Tj 2.080556 0 Td 64.814815 Tz (pre ) Tj 51.428571 0 0 51.428571 0 2264.223729 Tm 25.297222 0 Td 48.148148 Tz (dicting ) Tj 2.197222 0 Td 51.262626 Tz (progression ) Tj 3.597222 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 44.444444 Tz (retinal ) Tj 2.041667 0 Td 48.881173 Tz (pathologies. ) Tj 38.571429 0 0 38.571429 0 2185 Tm 42.388889 0 Td 90.740741 Tz (DEFINITIONS ) Tj 51.428571 0 0 51.428571 0 2091.03856 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.341667 0 Td 46.296296 Tz (instant ) Tj 2.119444 0 Td 49.691358 Tz (invention ) Tj 2.916667 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 59.143519 Tz (most ) Tj 1.594444 0 Td 46.759259 Tz (clearly ) Tj 2.177778 0 Td 53.796296 Tz (understood ) Tj 3.402778 0 Td 53.472222 Tz (with ) Tj 1.516667 0 Td 56.17284 Tz (ref ) Tj 51.428571 0 0 51.428571 0 2048.411642 Tm 25.297222 0 Td 52.932099 Tz (erence ) Tj 2.1 0 Td 42.12963 Tz (to ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 52.211934 Tz (following ) Tj 2.994444 0 Td 44.830247 Tz (definitions: ) Tj 51.428571 0 0 51.428571 0 2006.208279 Tm 26.016667 0 Td 66.435185 Tz (As ) Tj 1.011111 0 Td 55.092593 Tz (used ) Tj 1.516667 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 46.866097 Tz (specification ) Tj 3.869444 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 49.074074 Tz (claims, ) Tj 2.236111 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 49.421296 Tz (singular ) Tj 2.547222 0 Td 58.333333 Tz (form ) Tj 51.428571 0 0 51.428571 0 1959.890026 Tm 25.297222 0 Td 45.37037 Tz (a, ) Tj 1.244444 0 Td 58.333333 Tz (an ) Tj 1.652778 0 Td 58.333333 Tz (and ) Tj 1.186111 0 Td 52.662037 Tz (the ) Tj 1.730556 0 Td 50.925926 Tz (include ) Tj 2.294444 0 Td 46.990741 Tz (plural ) Tj 1.905556 0 Td 48.935185 Tz (references ) Tj 3.111111 0 Td 50.231481 Tz (unless ) Tj 2.002778 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 1916.911007 Tm 25.277778 0 Td 46.180556 Tz (text ) Tj 1.283333 0 Td 47.222222 Tz (clearly ) Tj 2.158333 0 Td 46.180556 Tz (dictates ) Tj 2.391667 0 Td 49.907407 Tz (otherwise. ) Tj 51.428571 0 0 51.428571 0 1874.023591 Tm 26.016667 0 Td 87.5 Tz (A ) Tj 0.758333 0 Td 50.05144 Tz (subject' ) Tj 2.955556 0 Td 46.018519 Tz (shall ) Tj 1.594444 0 Td 59.953704 Tz (be ) Tj 0.952778 0 Td 53.796296 Tz (understood ) Tj 3.461111 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 50.925926 Tz (include ) Tj 2.352778 0 Td 58.333333 Tz (any ) Tj 1.322222 0 Td 70.216049 Tz (mammal ) Tj 51.428571 0 0 51.428571 0 1830.978177 Tm 25.297222 0 Td 48.611111 Tz (including, ) Tj 3.208333 0 Td 51.851852 Tz (but ) Tj 1.244444 0 Td 49.691358 Tz (not ) Tj 1.166667 0 Td 49.537037 Tz (limited ) Tj 2.372222 0 Td 39.969136 Tz (to, ) Tj 0.991667 0 Td 58.333333 Tz (humans. ) Tj 2.722222 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 53.472222 Tz (term ) Tj 1.594444 0 Td 50.411523 Tz (subject ) Tj 51.428571 0 0 51.428571 0 1792.711628 Tm 25.316667 0 Td 45.910494 Tz (specifically ) Tj 3.5 0 Td 49.826389 Tz (includes ) Tj 2.586111 0 Td 49.331276 Tz (primates. ) Tj 51.428571 0 0 51.428571 0 1747.816327 Tm 26.016667 0 Td 87.5 Tz (A ) Tj 0.719444 0 Td 49.537037 Tz (health ) Tj 2.255556 0 Td 51.851852 Tz (care ) Tj 1.4 0 Td 55.591168 Tz (providershall ) Tj 4.530556 0 Td 58.333333 Tz (be ) Tj 0.875 0 Td 54.12037 Tz (understood ) Tj 3.422222 0 Td 45.37037 Tz (to ) Tj 0.777778 0 Td 64.00463 Tz (mean ) Tj 1.730556 0 Td 57.253086 Tz (any ) Tj 51.428571 0 0 51.428571 0 1707.907912 Tm 25.297222 0 Td 53.472222 Tz (person ) Tj 2.216667 0 Td 52.572016 Tz (providing ) Tj 3.15 0 Td 54.166667 Tz (medical ) Tj 2.605556 0 Td 50.231481 Tz (care ) Tj 1.497222 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 46.180556 Tz (subject. ) Tj 2.547222 0 Td 59.953704 Tz (Such ) Tj 1.75 0 Td 52.777778 Tz (persons ) Tj 51.428571 0 0 51.428571 0 1663.92503 Tm 25.297222 0 Td 48.206019 Tz (include, ) Tj 2.469444 0 Td 50.771605 Tz (but ) Tj 1.05 0 Td 49.691358 Tz (are ) Tj 1.069444 0 Td 49.691358 Tz (not ) Tj 1.05 0 Td 48.611111 Tz (limited ) Tj 2.158333 0 Td 42.12963 Tz (to, ) Tj 0.933333 0 Td 54.166667 Tz (medical ) Tj 2.430556 0 Td 50.462963 Tz (doctors ) Tj 2.275 0 Td 40.509259 Tz (\(e.g., ) Tj 1.613889 0 Td 57.407407 Tz (ophthal ) Tj 52.857143 0 0 52.857143 0 1623.888889 Tm 24.613514 0 Td 48.558559 Tz (mologists, ) Tj 3.102703 0 Td 46.812197 Tz (optometrists, ) Tj 3.821622 0 Td 56.756757 Tz (and ) Tj 1.172973 0 Td 49.399399 Tz (the ) Tj 1.040541 0 Td 40.465465 Tz (like\), ) Tj 1.608108 0 Td 53.603604 Tz (physicians ) Tj 3.367568 0 Td 43.284193 Tz (assistants, ) Tj 51.428571 0 0 51.428571 0 1581.925408 Tm 25.297222 0 Td 52.5 Tz (nurse ) Tj 1.691667 0 Td 46.616809 Tz (practitioners ) Tj 3.752778 0 Td 41.049383 Tz (\(e.g., ) Tj 1.575 0 Td 58.333333 Tz (an ) Tj 0.777778 0 Td 61.168981 Tz (Advanced ) Tj 3.091667 0 Td 51.203704 Tz (Registered ) Tj 3.169444 0 Td 58.981481 Tz (Nurse ) Tj 1.886111 0 Td 63.194444 Tz (Prac ) Tj 51.428571 0 0 51.428571 0 1536 Tm 25.277778 0 Td 44.965278 Tz (titioner ) Tj 2.275 0 Td 58.333333 Tz (\(ARNP\)\), ) Tj 2.936111 0 Td 48.148148 Tz (nurses, ) Tj 2.158333 0 Td 45.694444 Tz (residents, ) Tj 2.858333 0 Td 44.965278 Tz (interns, ) Tj 2.313889 0 Td 53.240741 Tz (medical ) Tj 2.391667 0 Td 46.8107 Tz (students, ) Tj 51.428571 0 0 51.428571 0 1498.071429 Tm 25.297222 0 Td 53.472222 Tz (or ) Tj 0.913889 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 40.833333 Tz (like. ) Tj 1.516667 0 Td 57.118056 Tz (Although ) Tj 3.091667 0 Td 49.537037 Tz (various ) Tj 2.411111 0 Td 48.971193 Tz (licensure ) Tj 2.955556 0 Td 52.662037 Tz (requirements ) Tj 4.122222 0 Td 68.055556 Tz (may ) Tj 51.428571 0 0 51.428571 0 1455.603254 Tm 25.297222 0 Td 53.148148 Tz (apply ) Tj 1.769444 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 59.41358 Tz (one ) Tj 1.263889 0 Td 50.231481 Tz (or ) Tj 0.797222 0 Td 60.763889 Tz (more ) Tj 1.633333 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 52.441077 Tz (occupations ) Tj 3.655556 0 Td 43.75 Tz (listed ) Tj 1.75 0 Td 57.037037 Tz (above ) Tj 1.886111 0 Td 46.990741 Tz (in ) Tj 0.777778 0 Td 55.092593 Tz (vari ) Tj 51.428571 0 0 51.428571 0 1414.160976 Tm 25.297222 0 Td 55.092593 Tz (ous ) Tj 1.166667 0 Td 45.37037 Tz (jurisdictions, ) Tj 4.005556 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 55.902778 Tz (term ) Tj 1.536111 0 Td 50.231481 Tz (health ) Tj 2.022222 0 Td 50.231481 Tz (care ) Tj 1.380556 0 Td 51.851852 Tz (provider ) Tj 2.663889 0 Td 40.509259 Tz (is ) Tj 0.7 0 Td 68.981481 Tz (unencum ) Tj 51.428571 0 0 51.428571 0 1374.802395 Tm 25.277778 0 Td 54.444444 Tz (bered ) Tj 1.808333 0 Td 49.691358 Tz (for ) Tj 1.011111 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 54.282407 Tz (purposes ) Tj 2.8 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 43.75 Tz (this ) Tj 1.244444 0 Td 49.691358 Tz (patent ) Tj 1.944444 0 Td 47.260802 Tz (application. ) Tj 38.571429 0 0 38.571429 0 1299 Tm 37.644444 0 Td 95.454545 Tz (DESCRIPTION ) Tj 6.533333 0 Td 101.54321 Tz (OF ) Tj 1.451852 0 Td 106.584362 Tz (THE ) Tj 2.22963 0 Td 97.462277 Tz (INVENTION ) Tj 51.428571 0 0 51.428571 0 1211.513174 Tm 26.016667 0 Td 54.62963 Tz (Aspects ) Tj 2.469444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 49.691358 Tz (invention ) Tj 2.877778 0 Td 52.777778 Tz (provide ) Tj 2.372222 0 Td 54.62963 Tz (systems ) Tj 2.45 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 57.87037 Tz (methods ) Tj 2.605556 0 Td 49.691358 Tz (for ) Tj 51.428571 0 0 51.428571 0 1170.524272 Tm 25.297222 0 Td 48.971193 Tz (detection ) Tj 2.916667 0 Td 55.092593 Tz (of ) Tj 0.816667 0 Td 43.518519 Tz (retinal ) Tj 2.061111 0 Td 48.881173 Tz (pathologies. ) Tj 3.791667 0 Td 57.973251 Tz (Exemplary ) Tj 3.402778 0 Td 43.518519 Tz (retinal ) Tj 2.061111 0 Td 57.407407 Tz (patholo ) Tj 51.428571 0 0 51.428571 0 1128.333333 Tm 25.297222 0 Td 48.611111 Tz (gies ) Tj 1.691667 0 Td 50.925926 Tz (include ) Tj 2.625 0 Td 55.812757 Tz (glaucoma, ) Tj 3.538889 0 Td 56.018519 Tz (macular ) Tj 2.838889 0 Td 50.106838 Tz (degeneration, ) Tj 4.452778 0 Td 56.018519 Tz (macular ) Tj 51.428571 0 0 51.428571 0 1084.05679 Tm 25.297222 0 Td 57.79321 Tz (edema, ) Tj 2.255556 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 40.833333 Tz (like. ) Tj 1.477778 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 64.00463 Tz (some ) Tj 1.711111 0 Td 56.983025 Tz (embodiments, ) Tj 4.277778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 57.79321 Tz (pathol ) Tj 51.428571 0 0 51.428571 0 1043.964467 Tm 25.297222 0 Td 59.41358 Tz (ogy ) Tj 1.302778 0 Td 38.888889 Tz (is ) Tj 0.680556 0 Td 50.636574 Tz (detected ) Tj 2.625 0 Td 53.703704 Tz (through ) Tj 2.469444 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 52.932099 Tz (use ) Tj 1.147222 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 43.981481 Tz (fractal ) Tj 2.041667 0 Td 49.016204 Tz (analysis ) Tj 2.605556 0 Td 55.092593 Tz (of ) Tj 0.797222 0 Td 58.333333 Tz (one ) Tj 1.263889 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 1005.034483 Tm 25.297222 0 Td 62.384259 Tz (more ) Tj 1.691667 0 Td 56.712963 Tz (images ) Tj 2.255556 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.180556 Tz (subject. ) Tj 51.428571 0 0 51.428571 0 960.567901 Tm 25.316667 0 Td 47.395833 Tz (Fractals ) Tj 2.45 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 47.685185 Tz (Fractal ) Tj 2.158333 0 Td 52.662037 Tz (Analysis ) Tj 51.428571 0 0 51.428571 0 921.964467 Tm 26.016667 0 Td 87.5 Tz (A ) Tj 0.661111 0 Td 44.444444 Tz (fractal ) Tj 2.022222 0 Td 38.888889 Tz (is ) Tj 0.583333 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 55.740741 Tz (rough ) Tj 1.827778 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 54.768519 Tz (fragmented ) Tj 3.422222 0 Td 53.652263 Tz (geometric ) Tj 3.052778 0 Td 55.092593 Tz (shape ) Tj 1.788889 0 Td 53.472222 Tz (with ) Tj 1.438889 0 Td 58.333333 Tz (an ) Tj 51.428571 0 0 51.428571 0 876.627284 Tm 25.297222 0 Td 42.939815 Tz (infinite ) Tj 2.236111 0 Td 49.537037 Tz (nesting ) Tj 2.216667 0 Td 58.333333 Tz (of ) Tj 0.758333 0 Td 46.8107 Tz (structure ) Tj 2.683333 0 Td 45.37037 Tz (at ) Tj 0.661111 0 Td 41.049383 Tz (all ) Tj 0.913889 0 Td 44.444444 Tz (scales. ) Tj 2.061111 0 Td 59.143519 Tz (Each ) Tj 1.555556 0 Td 48.611111 Tz (part ) Tj 1.302778 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.486111 0 Td 43.981481 Tz (fractal ) Tj 51.428571 0 0 51.428571 0 834.838254 Tm 25.297222 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 50.501543 Tz (reduced-size ) Tj 3.85 0 Td 59.143519 Tz (copy ) Tj 1.652778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 54.012346 Tz (whole. ) Tj 2.216667 0 Td 47.222222 Tz (Fractal ) Tj 2.236111 0 Td 49.074074 Tz (objects ) Tj 2.294444 0 Td 55.092593 Tz (can ) Tj 1.225 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 794.682635 Tm 25.297222 0 Td 57.685185 Tz (found ) Tj 1.827778 0 Td 56.388889 Tz (everywhere ) Tj 3.538889 0 Td 46.990741 Tz (in ) Tj 0.738889 0 Td 49.691358 Tz (nature ) Tj 1.925 0 Td 55.092593 Tz (Such ) Tj 1.477778 0 Td 51.851852 Tz (as ) Tj 0.777778 0 Td 48.611111 Tz (clouds, ) Tj 2.216667 0 Td 56.712963 Tz (mountain ) Tj 2.877778 0 Td 49.074074 Tz (ranges, ) Tj 51.428571 0 0 51.428571 0 751.565632 Tm 25.297222 0 Td 46.254209 Tz (coastlines, ) Tj 3.227778 0 Td 48.316498 Tz (vegetables, ) Tj 3.325 0 Td 61.574074 Tz (Snow ) Tj 1.672222 0 Td 43.981481 Tz (flakes, ) Tj 1.983333 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 45.37037 Tz (bacteria. ) Tj 2.625 0 Td 68.865741 Tz (Some ) Tj 1.808333 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 712.47619 Tm 25.297222 0 Td 48.287037 Tz (properties ) Tj 3.072222 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 44.155093 Tz (fractals ) Tj 2.294444 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 43.75 Tz (self-similarity, ) Tj 4.413889 0 Td 50.231481 Tz (chaos, ) Tj 1.963889 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 55.092593 Tz (non-inte ) Tj 51.428571 0 0 51.428571 0 668.037037 Tm 25.297222 0 Td 52.932099 Tz (ger ) Tj 1.127778 0 Td 43.518519 Tz (fractal ) Tj 2.022222 0 Td 55.812757 Tz (dimension ) Tj 3.227778 0 Td 51.851852 Tz (\(FD\). ) Tj 51.428571 0 0 51.428571 0 627.879195 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.458333 0 Td 43.981481 Tz (fractal ) Tj 2.197222 0 Td 55.812757 Tz (dimension ) Tj 3.344444 0 Td 46.450617 Tz (offers ) Tj 2.002778 0 Td 51.851852 Tz (a ) Tj 0.661111 0 Td 47.260802 Tz (quantitative ) Tj 3.772222 0 Td 56.944444 Tz (measure ) Tj 2.702778 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 588.134161 Tm 25.316667 0 Td 45.154321 Tz (self-similarity ) Tj 4.316667 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 46.180556 Tz (scaling. ) Tj 2.488889 0 Td 62.654321 Tz (The ) Tj 1.419444 0 Td 74.537037 Tz (FD ) Tj 1.147222 0 Td 48.611111 Tz (characterizes ) Tj 4.025 0 Td 58.333333 Tz (an ) Tj 0.952778 0 Td 50.231481 Tz (object ) Tj 51.428571 0 0 51.428571 0 546.74463 Tm 25.277778 0 Td 54.282407 Tz (with ) Tj 1.477778 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 51.157407 Tz (dimensionality ) Tj 4.472222 0 Td 49.537037 Tz (greater ) Tj 2.216667 0 Td 51.851852 Tz (than ) Tj 1.438889 0 Td 37.808642 Tz (its ) Tj 0.855556 0 Td 49.789562 Tz (topological ) Tj 3.480556 0 Td 56.532922 Tz (dimension ) Tj 51.428571 0 0 51.428571 0 502.125628 Tm 25.316667 0 Td 54.282407 Tz (Such ) Tj 1.497222 0 Td 46.990741 Tz (that ) Tj 1.283333 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 43.981481 Tz (fractal ) Tj 2.061111 0 Td 53.796296 Tz (curve ) Tj 1.808333 0 Td 52.932099 Tz (has ) Tj 1.147222 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 55.812757 Tz (dimension ) Tj 3.227778 0 Td 57.407407 Tz (between ) Tj 2.625 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 45.37037 Tz (straight ) Tj 51.428571 0 0 51.428571 0 459.780024 Tm 25.297222 0 Td 45.37037 Tz (line ) Tj 1.205556 0 Td 58.333333 Tz (and ) Tj 1.127778 0 Td 58.333333 Tz (a ) Tj 0.447222 0 Td 53.148148 Tz (plane ) Tj 1.730556 0 Td 61.168981 Tz (\(1> stream q endstream endobj 393 0 obj << /Length 46365 >> stream Q q 0.24 0 0 0.24 0 0 cm BT /F1 1 Tf 3 Tr 62.857143 0 0 62.857143 0 3023 Tm 17.325 0 Td 83.522727 Tz (US ) Tj 1.240909 0 Td 58.333333 Tz (8,632,186 ) Tj 3.388636 0 Td 74.242424 Tz (B2 ) Tj 51.428571 0 0 51.428571 0 2968 Tm 14.875 0 Td 77.777778 Tz (7 ) Tj 38.571429 0 0 38.571429 0 2873 Tm 30.877778 0 Td 46.090535 Tz (\(1\) ) Tj 40 0 0 40 0 2872.156627 Tm 14.125 0 Td 56.018519 Tz (ln\(number ) Tj 3.175 0 Td 56.25 Tz (of ) Tj 0.925 0 Td 54.166667 Tz (self-similar ) Tj 4.025 0 Td 47.619048 Tz (pieces, ) Tj 2.25 0 Td 64.583333 Tz (N\) ) Tj 31.428571 0 0 31.428571 0 2838 Tm 29.177273 0 Td 53.030303 Tz (1 ) Tj 58.571429 0 0 58.571429 0 2810.478873 Tm 10.82439 0 Td 29.878049 Tz (In ) Tj 0.495122 0 Td 35.678549 Tz (magnification ) Tj 2.834146 0 Td 29.674797 Tz (factor, ) Tj 1.434146 0 Td 51.219512 Tz (- ) Tj 0.358537 0 Td 25.609756 Tz (\) ) Tj 51.428571 0 0 51.428571 0 2685.367862 Tm 7.116667 0 Td 57.407407 Tz (Because ) Tj 2.625 0 Td 69.351852 Tz (TSNIT ) Tj 2.352778 0 Td 50.231481 Tz (data ) Tj 1.477778 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 48.611111 Tz (representation ) Tj 4.375 0 Td 56.712963 Tz (of ) Tj 0.855556 0 Td 57.79321 Tz (pseudo ) Tj 2.352778 0 Td 72.376543 Tz (two ) Tj 48.571429 0 0 48.571429 0 2641 Tm 6.732353 0 Td 57.085561 Tz (dimensional ) Tj 3.973529 0 Td 52.614379 Tz (thickness ) Tj 3.067647 0 Td 60.04902 Tz (of ) Tj 0.864706 0 Td 70.686275 Tz (RNFL, ) Tj 2.305882 0 Td 63.012478 Tz (embodiments ) Tj 4.364706 0 Td 61.764706 Tz (of ) Tj 0.823529 0 Td 53.75817 Tz (the ) Tj 1.173529 0 Td 63.823529 Tz (inven ) Tj 40 0 0 40 0 2603 Tm 8.15 0 Td 61.458333 Tz (tion ) Tj 1.7 0 Td 65.47619 Tz (convert ) Tj 2.95 0 Td 63.888889 Tz (the ) Tj 1.375 0 Td 69.166667 Tz 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2.041667 0 Td 57.79321 Tz (pathol ) Tj 51.428571 0 0 51.428571 0 2212.296296 Tm 6.358333 0 Td 60.493827 Tz (ogy ) Tj 1.283333 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 46.180556 Tz (subject. ) Tj 51.428571 0 0 51.428571 0 2167.234133 Tm 7.097222 0 Td 50.231481 Tz (In ) Tj 0.913889 0 Td 46.990741 Tz (step ) Tj 1.477778 0 Td 55.740741 Tz (S102, ) Tj 1.944444 0 Td 70 Tz (TSNIT ) Tj 2.411111 0 Td 76.157407 Tz (RNFL ) Tj 2.177778 0 Td 48.611111 Tz (data ) Tj 1.516667 0 Td 37.268519 Tz (is ) Tj 0.777778 0 Td 50.411523 Tz (provided. ) Tj 3.072222 0 Td 48.611111 Tz (In ) Tj 0.913889 0 Td 64.00463 Tz (some ) Tj 48.571429 0 0 48.571429 0 2125 Tm 6.732353 0 Td 60.334967 Tz (embodiments, ) Tj 4.632353 0 Td 51.470588 Tz (the ) Tj 1.152941 0 Td 74.117647 Tz (TSNIT ) Tj 2.491176 0 Td 80.637255 Tz (RNFL ) Tj 2.202941 0 Td 53.186275 Tz (data ) Tj 1.544118 0 Td 58.333333 Tz (can ) Tj 1.297059 0 Td 63.480392 Tz (be ) Tj 0.988235 0 Td 61.764706 Tz (a ) Tj 0.658824 0 Td 65.196078 Tz (one-dimen ) Tj 51.428571 0 0 51.428571 0 2084.415484 Tm 6.377778 0 Td 46.990741 Tz (sional ) Tj 1.983333 0 Td 51.041667 Tz (data ) Tj 1.497222 0 Td 44.290123 Tz (set ) Tj 1.088889 0 Td 48.935185 Tz (consisting ) Tj 3.188889 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 50.231481 Tz (data ) Tj 1.497222 0 Td 49.074074 Tz (vectors ) Tj 2.333333 0 Td 52.256944 Tz (obtained ) Tj 2.780556 0 Td 53.796296 Tz (along ) Tj 1.886111 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2043.751523 Tm 6.377778 0 Td 46.866097 Tz (Substantially ) Tj 3.830556 0 Td 46.990741 Tz (circular ) Tj 2.372222 0 Td 51.851852 Tz (path ) Tj 1.458333 0 Td 43.75 Tz (in ) Tj 0.680556 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 45.910494 Tz (retina ) Tj 1.827778 0 Td 57.523148 Tz (from ) Tj 1.555556 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 53.877315 Tz (scanning ) Tj 2.780556 0 Td 46.018519 Tz (laser ) Tj 51.428571 0 0 51.428571 0 2000.692308 Tm 6.338889 0 Td 51.851852 Tz (polarimetry ) Tj 3.597222 0 Td 52.391975 Tz (device ) Tj 2.061111 0 Td 55.092593 Tz (such ) Tj 1.516667 0 Td 48.611111 Tz (as ) Tj 0.797222 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 74.94213 Tz (GDxVCCTM ) Tj 3.811111 0 Td 51.851852 Tz (device ) Tj 2.022222 0 Td 48.611111 Tz (available ) Tj 48.571429 0 0 48.571429 0 1959 Tm 6.732353 0 Td 61.764706 Tz (from ) Tj 1.852941 0 Td 55.759804 Tz (Carl ) Tj 1.75 0 Td 53.529412 Tz (Zeiss ) Tj 1.997059 0 Td 59.313725 Tz (Meditec ) Tj 2.923529 0 Td 46.323529 Tz (Inc. ) Tj 1.523529 0 Td 61.764706 Tz (of ) Tj 1.05 0 Td 54.901961 Tz (Dublin, ) Tj 2.676471 0 Td 47.46732 Tz (Calif. ) Tj 2.161765 0 Td 48.039216 Tz (In ) Tj 0.988235 0 Td 53.529412 Tz (other ) Tj 51.428571 0 0 51.428571 0 1917.355828 Tm 6.358333 0 Td 56.983025 Tz (embodiments, ) Tj 4.297222 0 Td 48.611111 Tz (the ) Tj 1.011111 0 Td 69.351852 Tz (TSNIT ) Tj 2.275 0 Td 76.157407 Tz (RNFL ) Tj 2.002778 0 Td 49.421296 Tz (data ) Tj 1.380556 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 53.877315 Tz (provided ) Tj 2.741667 0 Td 58.333333 Tz (by ) Tj 0.894444 0 Td 55.092593 Tz (an ) Tj 0.836111 0 Td 57.523148 Tz (opti ) Tj 51.428571 0 0 51.428571 0 1877.205919 Tm 6.358333 0 Td 46.450617 Tz (cal ) Tj 1.108333 0 Td 54.372428 Tz (coherence ) Tj 3.188889 0 Td 57.973251 Tz (tomograph ) Tj 3.383333 0 Td 53.472222 Tz (and/or ) Tj 2.119444 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 53.148148 Tz (Heidelberg ) Tj 3.422222 0 Td 46.450617 Tz (retina ) Tj 1.886111 0 Td 72.916667 Tz (tomo ) Tj 51.428571 0 0 51.428571 0 1840 Tm 6.358333 0 Td 50.231481 Tz (graph. ) Tj 51.428571 0 0 51.428571 0 1794.271795 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.7 0 Td 48.611111 Tz (step ) Tj 1.302778 0 Td 55.740741 Tz (S104, ) Tj 1.788889 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 50.231481 Tz (data ) Tj 1.341667 0 Td 45.37037 Tz (set ) Tj 0.952778 0 Td 37.268519 Tz (is ) Tj 0.602778 0 Td 50.771605 Tz (separated ) Tj 2.877778 0 Td 46.180556 Tz (into ) Tj 1.263889 0 Td 55.092593 Tz (a ) Tj 0.427778 0 Td 47.800926 Tz (training ) Tj 2.430556 0 Td 44.290123 Tz (set 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6.358333 0 Td 48.112536 Tz (effectiveness ) Tj 3.927778 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 49.074074 Tz (trained ) Tj 2.255556 0 Td 44.675926 Tz (classification ) Tj 3.927778 0 Td 50.231481 Tz (algorithm. ) Tj 3.227778 0 Td 48.611111 Tz (In ) Tj 0.758333 0 Td 64.814815 Tz (some ) Tj 50 0 0 50 0 1625 Tm 6.54 0 Td 58.611111 Tz (embodiments, ) Tj 4.4 0 Td 53.333333 Tz (a ) Tj 0.5 0 Td 48.518519 Tz (variation ) Tj 2.82 0 Td 58.333333 Tz (of ) Tj 0.84 0 Td 51.428571 Tz (10-fold ) Tj 2.32 0 Td 50.666667 Tz (cross ) Tj 1.7 0 Td 49.666667 Tz (validation ) Tj 3.18 0 Td 38.333333 Tz (is ) Tj 0.62 0 Td 52 Tz (used, ) Tj 51.428571 0 0 51.428571 0 1586.074349 Tm 6.358333 0 Td 50.231481 Tz (as ) Tj 0.816667 0 Td 32.407407 Tz (it ) Tj 0.583333 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 50.231481 Tz (Superior ) Tj 2.547222 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 45.046296 Tz (split-half ) Tj 2.8 0 Td 60.493827 Tz (method ) Tj 2.352778 0 Td 58.333333 Tz (and ) Tj 1.225 0 Td 40.509259 Tz (is ) Tj 0.680556 0 Td 47.962963 Tz (especially ) Tj 3.052778 0 Td 66.111111 Tz (advan ) Tj 51.428571 0 0 51.428571 0 1543.720207 Tm 6.338889 0 Td 53.703704 Tz (tageous ) Tj 2.488889 0 Td 64.814815 Tz (when ) Tj 1.788889 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 51.851852 Tz (very ) Tj 1.516667 0 Td 47.314815 Tz (large ) Tj 1.652778 0 Td 57.253086 Tz (sample ) Tj 2.313889 0 Td 37.268519 Tz (is ) Tj 0.738889 0 Td 49.691358 Tz (not ) Tj 1.108333 0 Td 46.018519 Tz (available. ) Tj 3.052778 0 Td 55.092593 Tz (For ) Tj 1.166667 0 Td 44.560185 Tz (this ) Tj 51.428571 0 0 51.428571 0 1502.745498 Tm 6.358333 0 Td 51.527778 Tz (procedure, ) Tj 3.227778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.636574 Tz (majority ) Tj 2.605556 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.074074 Tz (subject ) Tj 2.177778 0 Td 51.041667 Tz (data ) Tj 1.361111 0 Td 45.37037 Tz (sets ) Tj 1.244444 0 Td 43.209877 Tz (\(in ) Tj 0.933333 0 Td 64.814815 Tz (some ) Tj 1.691667 0 Td 66.975309 Tz (embodi ) Tj 51.428571 0 0 51.428571 0 1458.151439 Tm 6.358333 0 Td 52.932099 Tz (ments, ) Tj 2.119444 0 Td 64.814815 Tz (90%\) ) Tj 1.75 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 48.611111 Tz (selected ) Tj 2.527778 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 46.585648 Tz (training ) Tj 2.430556 0 Td 41.319444 Tz (set, ) Tj 1.166667 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 51.851852 Tz (classi ) Tj 51.428571 0 0 51.428571 0 1417.867305 Tm 6.358333 0 Td 45.37037 Tz (fication ) Tj 2.527778 0 Td 38.888889 Tz (is ) Tj 0.797222 0 Td 51.388889 Tz (applied ) Tj 2.488889 0 Td 46.990741 Tz (to ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 51.203704 Tz (Small ) Tj 1.866667 0 Td 43.75 Tz (test ) Tj 1.361111 0 Td 45.37037 Tz (set ) Tj 1.166667 0 Td 48.935185 Tz (consisting ) Tj 3.266667 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1377.673716 Tm 6.358333 0 Td 54.73251 Tz (remaining ) Tj 3.15 0 Td 50.555556 Tz (cases ) Tj 1.711111 0 Td 54.552469 Tz (\(10%\). ) Tj 51.428571 0 0 51.428571 0 1334.380697 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 47.800926 Tz (step ) Tj 1.419444 0 Td 55.740741 Tz (S106, ) Tj 1.944444 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 53.796296 Tz (one-dimensional ) Tj 5.113889 0 Td 50.231481 Tz (data ) Tj 1.477778 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 48.021886 Tz (interpreted ) Tj 3.441667 0 Td 45.37037 Tz (to ) Tj 51.428571 0 0 51.428571 0 1295.23753 Tm 6.358333 0 Td 54.012346 Tz (determine ) Tj 3.091667 0 Td 56.018519 Tz (whether ) Tj 2.488889 0 Td 54.282407 Tz (each ) Tj 1.497222 0 Td 49.537037 Tz (subject ) Tj 2.216667 0 Td 40.509259 Tz (is ) Tj 0.641667 0 Td 51.58179 Tz (pathologic' ) Tj 3.888889 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 47.962963 Tz (healthy. ) Tj 51.428571 0 0 51.428571 0 1254.16319 Tm 6.377778 0 Td 46.759259 Tz (Interpretation ) Tj 4.161111 0 Td 55.092593 Tz (can ) Tj 1.225 0 Td 51.388889 Tz (include ) Tj 2.391667 0 Td 58.873457 Tz (manual ) Tj 2.333333 0 Td 46.527778 Tz (interpretation ) Tj 4.141667 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 55.740741 Tz (quali ) Tj 51.428571 0 0 51.428571 0 1210.179028 Tm 6.358333 0 Td 46.180556 Tz (fied ) Tj 1.4 0 Td 48.611111 Tz (individual ) Tj 3.208333 0 Td 40.509259 Tz (\(e.g., ) Tj 1.769444 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 49.691358 Tz (health ) Tj 2.1 0 Td 50.231481 Tz (care ) Tj 1.497222 0 Td 49.691358 Tz (provider\) ) Tj 2.975 0 Td 53.472222 Tz (or ) Tj 0.875 0 Td 57.253086 Tz (automated ) Tj 51.428571 0 0 51.428571 0 1168.323208 Tm 6.358333 0 Td 46.527778 Tz (interpretation ) Tj 4.083333 0 Td 61.574074 Tz (by ) Tj 0.913889 0 Td 59.41358 Tz (one ) Tj 1.244444 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 61.574074 Tz (more ) Tj 1.633333 0 Td 56.712963 Tz (hardware ) Tj 2.897222 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 51.851852 Tz (software ) Tj 2.663889 0 Td 48.206019 Tz (devices. ) Tj 51.428571 0 0 51.428571 0 1124.609819 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 47.800926 Tz (step ) Tj 1.361111 0 Td 55.092593 Tz (S108, ) Tj 1.847222 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 54.012346 Tz (one-dimensional ) Tj 5.036111 0 Td 50.231481 Tz (data ) Tj 1.4 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 52.572016 Tz (converted ) Tj 3.033333 0 Td 45.37037 Tz (into ) Tj 1.263889 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 1086.179245 Tm 6.358333 0 Td 56.712963 Tz (pseudo ) Tj 2.177778 0 Td 54.228395 Tz (two-dimensional ) Tj 5.016667 0 Td 54.012346 Tz (format ) Tj 2.041667 0 Td 59.953704 Tz (by ) Tj 0.855556 0 Td 47.395833 Tz (plotting ) Tj 2.372222 0 Td 55.092593 Tz (each ) Tj 1.477778 0 Td 49.421296 Tz (data ) Tj 1.302778 0 Td 50.555556 Tz (point ) Tj 1.613889 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 1044.17491 Tm 6.338889 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 52.314815 Tz (y-value ) Tj 2.352778 0 Td 51.851852 Tz (with ) Tj 1.419444 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 53.846154 Tz (corresponding ) Tj 4.355556 0 Td 52.5 Tz (index ) Tj 1.691667 0 Td 51.851852 Tz (as ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 48.206019 Tz (x-value. ) Tj 2.527778 0 Td 53.472222 Tz (FIG. ) Tj 51.428571 0 0 51.428571 0 1001.671795 Tm 6.358333 0 Td 74.537037 Tz (2A ) Tj 1.166667 0 Td 48.148148 Tz (depicts ) Tj 2.275 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 47.800926 Tz (plot ) Tj 1.380556 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 53.796296 Tz (one-dimensional ) Tj 5.152778 0 Td 48.611111 Tz (vectors ) Tj 2.275 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 54.282407 Tz (FIG. ) Tj 1.613889 0 Td 66.435185 Tz (2B ) Tj 51.428571 0 0 51.428571 0 962.154964 Tm 6.358333 0 Td 49.074074 Tz (depicts ) Tj 2.236111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 57.253086 Tz (pseudo ) Tj 2.216667 0 Td 54.228395 Tz (two-dimensional ) Tj 5.094444 0 Td 58.981481 Tz (image ) Tj 1.944444 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 51.041667 Tz (64-point ) Tj 2.625 0 Td 45.37037 Tz (set ) Tj 0.991667 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 917.783354 Tm 6.358333 0 Td 69.351852 Tz (TSNIT ) Tj 2.275 0 Td 47.395833 Tz (features ) Tj 2.469444 0 Td 52.662037 Tz (obtained ) Tj 2.741667 0 Td 51.851852 Tz (using ) Tj 1.769444 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 74.94213 Tz (GDxVCCTM ) Tj 3.830556 0 Td 51.851852 Tz (device ) Tj 2.041667 0 Td 63.194444 Tz (on ) Tj 0.933333 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 878.410628 Tm 6.377778 0 Td 45.775463 Tz (subject. ) Tj 2.352778 0 Td 50.231481 Tz (In ) Tj 0.7 0 Td 55.092593 Tz (both ) Tj 1.438889 0 Td 56.388889 Tz (FIGS. ) Tj 1.866667 0 Td 72.916667 Tz (2A ) Tj 0.972222 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 56.17284 Tz (2B, ) Tj 1.147222 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 49.151235 Tz (y-axis ) Tj 1.925 0 Td 48.287037 Tz (represents ) Tj 3.072222 0 Td 75.347222 Tz (RNFL ) Tj 51.428571 0 0 51.428571 0 834.502488 Tm 6.338889 0 Td 50.411523 Tz (thickness ) Tj 2.975 0 Td 50.231481 Tz (values ) Tj 2.002778 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 49.151235 Tz (X-axis ) Tj 2.002778 0 Td 48.935185 Tz (represents ) Tj 3.130556 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 53.796296 Tz (index ) Tj 1.827778 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 800 Tm 6.358333 0 Td 46.296296 Tz (points. ) Tj 51.428571 0 0 51.428571 0 753.469755 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.738889 0 Td 48.611111 Tz (step ) Tj 1.361111 0 Td 55.092593 Tz (S110, ) Tj 1.827778 0 Td 44.444444 Tz (fractal ) Tj 2.022222 0 Td 48.611111 Tz (analysis ) Tj 2.527778 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 56.532922 Tz (performed ) Tj 3.227778 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 47.890947 Tz (calculate ) Tj 2.780556 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 709 Tm 6.377778 0 Td 47.685185 Tz (Fractal ) Tj 2.236111 0 Td 57.973251 Tz (Dimension ) Tj 3.344444 0 Td 51.851852 Tz (\(FD\). ) Tj 1.788889 0 Td 46.990741 Tz (In ) Tj 0.777778 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 57.744108 Tz (embodiment, ) Tj 4.005556 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 76.157407 Tz (FD ) Tj 1.108333 0 Td 55.092593 Tz (can ) Tj 1.166667 0 Td 59.953704 Tz (be ) Tj 51.428571 0 0 51.428571 0 670.649289 Tm 6.358333 0 Td 49.259259 Tz (calculated ) Tj 3.072222 0 Td 52.5 Tz (using ) Tj 1.711111 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 53.742284 Tz (box-counting ) Tj 4.025 0 Td 59.953704 Tz (method ) Tj 2.294444 0 Td 58.333333 Tz (on ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 56.712963 Tz (pseudo ) Tj 2.177778 0 Td 73.45679 Tz (two ) Tj 51.428571 0 0 51.428571 0 628.287081 Tm 6.358333 0 Td 53.619529 Tz (dimensional ) Tj 3.733333 0 Td 76.157407 Tz (RNFL ) Tj 1.944444 0 Td 50.231481 Tz (data ) Tj 1.361111 0 Td 51.041667 Tz (depicted ) Tj 2.586111 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 63.194444 Tz (FIG.2B ) Tj 2.411111 0 Td 48.611111 Tz (for ) Tj 0.972222 0 Td 55.902778 Tz (each ) Tj 1.497222 0 Td 45.775463 Tz (subject. ) Tj 51.428571 0 0 51.428571 0 586.082474 Tm 6.377778 0 Td 48.611111 Tz (In ) Tj 0.913889 0 Td 52.777778 Tz (another ) Tj 2.508333 0 Td 58.038721 Tz (embodiment, ) Tj 4.2 0 Td 48.611111 Tz (the ) Tj 1.244444 0 Td 74.537037 Tz (FD ) Tj 1.225 0 Td 54.552469 Tz (approximates ) Tj 4.277778 0 Td 50.771605 Tz (the ) Tj 1.225 0 Td 43.981481 Tz (fractal ) Tj 51.428571 0 0 51.428571 0 544.721019 Tm 6.358333 0 Td 55.812757 Tz (dimension ) Tj 3.480556 0 Td 54.79798 Tz (computation ) Tj 4.063889 0 Td 52.5 Tz (using ) Tj 2.002778 0 Td 50.771605 Tz (the ) Tj 1.380556 0 Td 55.092593 Tz (Hausdorff ) Tj 3.344444 0 Td 52.824074 Tz (dimension, ) Tj 51.428571 0 0 51.428571 0 501.750293 Tm 6.338889 0 Td 60.277778 Tz (which ) Tj 1.925 0 Td 55.092593 Tz (can ) Tj 1.108333 0 Td 56.712963 Tz (be ) Tj 0.797222 0 Td 49.259259 Tz (calculated ) Tj 3.072222 0 Td 51.851852 Tz (using ) Tj 1.652778 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 46.018519 Tz (fractional ) Tj 2.897222 0 Td 59.143519 Tz (Brownian ) Tj 2.955556 0 Td 57.79321 Tz (motion ) Tj 51.428571 0 0 51.428571 0 462.365854 Tm 6.338889 0 Td 52.175926 Tz (techniques ) Tj 3.383333 0 Td 51.49177 Tz (described ) Tj 2.994444 0 Td 50.231481 Tz (herein ) Tj 2.061111 0 Td 53.472222 Tz (or ) Tj 0.816667 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 52.211934 Tz (described ) Tj 3.013889 0 Td 46.990741 Tz (in ) Tj 0.777778 0 Td 49.691358 Tz (publications ) Tj 48.571429 0 0 48.571429 0 420 Tm 6.752941 0 Td 57.47549 Tz (such ) Tj 1.564706 0 Td 54.901961 Tz (as ) Tj 0.864706 0 Td 69.313725 Tz (Manav ) Tj 2.326471 0 Td 56.617647 Tz (Das, ) Tj 1.564706 0 Td 59.019608 Tz (Hausdorff ) Tj 3.644118 0 Td 57.95207 Tz (Measures, ) Tj 3.355882 0 Td 58.333333 Tz (Dimensions, ) Tj 4.014706 0 Td 65.196078 Tz (and ) Tj 51.428571 0 0 51.428571 0 378.911628 Tm 6.358333 0 Td 58.333333 Tz (Mutual ) Tj 2.236111 0 Td 50.717593 Tz (Singularity.357\(11\) ) Tj 6.222222 0 Td 49.691358 Tz (Trans. ) Tj 1.905556 0 Td 69.135802 Tz (Am. ) Tj 1.438889 0 Td 56.893004 Tz (Math.Soc. ) Tj 3.227778 0 Td 57.87037 Tz (4249-68 ) Tj 51.428571 0 0 51.428571 0 336.620489 Tm 6.377778 0 Td 50 Tz (\(2005\); ) Tj 2.255556 0 Td 66.435185 Tz (Mark ) Tj 1.730556 0 Td 43.425926 Tz (Pollicott, ) Tj 2.722222 0 Td 55.092593 Tz (Hausdorff ) Tj 3.383333 0 Td 58.693416 Tz (Dimension ) Tj 3.305556 0 Td 90.740741 Tz (& ) Tj 0.661111 0 Td 56.388889 Tz (Asymptotic ) Tj 51.428571 0 0 51.428571 0 295.480836 Tm 6.358333 0 Td 54.79798 Tz (Cycles.355 ) Tj 3.694444 0 Td 44.290123 Tz (\(8\) ) Tj 0.894444 0 Td 49.151235 Tz (Trans. ) Tj 1.905556 0 Td 69.135802 Tz (Am. ) Tj 1.380556 0 Td 58.333333 Tz (Math.Soc.3241-52 ) Tj 5.755556 0 Td 50.925926 Tz (\(2003\); ) Tj 2.255556 0 Td 65.625 Tz (Jang ) Tj 51.428571 0 0 51.428571 0 252.401242 Tm 6.358333 0 Td 64.814815 Tz (Mei ) Tj 1.438889 0 Td 63.734568 Tz (Wu, ) Tj 1.438889 0 Td 56.064815 Tz (Hausdorff ) Tj 3.538889 0 Td 58.333333 Tz (Dimension ) Tj 3.461111 0 Td 87.5 Tz (& ) Tj 0.816667 0 Td 57.118056 Tz (Doubling ) Tj 2.994444 0 Td 57.928241 Tz (Measures ) Tj 3.033333 0 Td 64.814815 Tz (on ) Tj 51.428571 0 0 51.428571 0 211.354497 Tm 6.358333 0 Td 53.472222 Tz (Metric ) Tj 2.294444 0 Td 51.851852 Tz (Spaces. ) Tj 2.936111 0 Td 52.932099 Tz (126\(5\) ) Tj 2.216667 0 Td 50.771605 Tz (Trans. ) Tj 2.197222 0 Td 69.135802 Tz (Am. ) Tj 1.652778 0 Td 56.388889 Tz (Math. ) Tj 2.080556 0 Td 52.662037 Tz (Soc. ) Tj 1.730556 0 Td 56.018519 Tz (1453-59 ) Tj 51.428571 0 0 51.428571 0 168 Tm 6.377778 0 Td 49.537037 Tz (\(1998\). ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.881081 0 Td 72.522523 Tz (8 ) Tj 51.428571 0 0 51.428571 0 2916.813699 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 46.450617 Tz (resulting ) Tj 2.8 0 Td 77.777778 Tz (FD ) Tj 1.186111 0 Td 38.888889 Tz (is ) Tj 0.719444 0 Td 51.851852 Tz (piece-wise ) Tj 3.422222 0 Td 41.666667 Tz (linear. ) Tj 2.061111 0 Td 46.990741 Tz (In ) Tj 0.855556 0 Td 47.800926 Tz (step ) Tj 1.419444 0 Td 55.740741 Tz (S112, ) Tj 1.963889 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2871.609697 Tm 25.316667 0 Td 49.691358 Tz (slopes ) Tj 1.944444 0 Td 57.407407 Tz (between ) Tj 2.586111 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 46.018519 Tz (fractional ) Tj 2.955556 0 Td 55.452675 Tz (dimension ) Tj 3.188889 0 Td 39.969136 Tz (\(e.g., ) Tj 1.613889 0 Td 60.493827 Tz (box ) Tj 1.263889 0 Td 44.722222 Tz (size\) ) Tj 1.516667 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 2827.660377 Tm 25.297222 0 Td 49.331276 Tz (extracted ) Tj 2.819444 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 61.574074 Tz (new ) Tj 1.341667 0 Td 45.37037 Tz (features. ) Tj 2.683333 0 Td 57.037037 Tz (FIGS. ) Tj 1.905556 0 Td 76.157407 Tz (3A ) Tj 1.088889 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 66.435185 Tz (3B ) Tj 1.030556 0 Td 49.691358 Tz (depict ) Tj 1.983333 0 Td 76.157407 Tz (FD ) Tj 1.088889 0 Td 47.314815 Tz (plots ) Tj 51.428571 0 0 51.428571 0 2784.132626 Tm 25.297222 0 Td 49.691358 Tz (for ) Tj 1.147222 0 Td 58.333333 Tz (two ) Tj 1.322222 0 Td 46.450617 Tz (subjects. ) Tj 2.8 0 Td 62.654321 Tz (The ) Tj 1.4 0 Td 46.666667 Tz (plots ) Tj 1.691667 0 Td 61.574074 Tz (show ) Tj 1.808333 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 43.981481 Tz (fractal ) Tj 2.119444 0 Td 47.800926 Tz (features ) Tj 2.605556 0 Td 47.530864 Tz (for ) Tj 1.108333 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2746.135959 Tm 25.316667 0 Td 48.070988 Tz (single ) Tj 2.041667 0 Td 56.17284 Tz (glaucomatous ) Tj 4.394444 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 50.925926 Tz (healthy ) Tj 2.508333 0 Td 46.180556 Tz (Subject, ) Tj 2.605556 0 Td 45.121083 Tz (respectfully. ) Tj 3.927778 0 Td 48.611111 Tz (In ) Tj 51.428571 0 0 51.428571 0 2697.346154 Tm 25.297222 0 Td 55.092593 Tz (each ) Tj 1.438889 0 Td 50.771605 Tz (graph, ) Tj 1.963889 0 Td 50.771605 Tz (the ) Tj 1.011111 0 Td 49.691358 Tz (X-axis ) Tj 1.944444 0 Td 48.611111 Tz (represents ) Tj 3.033333 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 46.990741 Tz (size ) Tj 1.263889 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 61.574074 Tz (box ) Tj 1.225 0 Td 48.611111 Tz (for ) Tj 0.972222 0 Td 43.981481 Tz (fractal ) Tj 51.428571 0 0 51.428571 0 2655.125604 Tm 25.297222 0 Td 54.79798 Tz (computation ) Tj 3.811111 0 Td 60.493827 Tz (and ) Tj 1.263889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 49.151235 Tz (y-axis ) Tj 2.002778 0 Td 48.611111 Tz (represents ) Tj 3.111111 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 43.518519 Tz (fractal ) Tj 2.022222 0 Td 56.893004 Tz (dimension ) Tj 51.428571 0 0 51.428571 0 2608 Tm 25.316667 0 Td 58.333333 Tz (\(FD\) ) Tj 1.594444 0 Td 47.530864 Tz (for ) Tj 1.011111 0 Td 55.092593 Tz (each ) Tj 1.497222 0 Td 61.574074 Tz (box ) Tj 1.302778 0 Td 42.777778 Tz (size. ) Tj 51.428571 0 0 51.428571 0 2567.477333 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 47.800926 Tz (step ) Tj 1.4 0 Td 55.092593 Tz (S114, ) Tj 1.905556 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 72.916667 Tz (FD ) Tj 1.108333 0 Td 47.800926 Tz (features ) Tj 2.527778 0 Td 49.691358 Tz (for ) Tj 1.088889 0 Td 50.87963 Tz (pathologic ) Tj 3.286111 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.925926 Tz (healthy ) Tj 51.428571 0 0 51.428571 0 2524.726846 Tm 25.297222 0 Td 46.990741 Tz (patients ) Tj 2.372222 0 Td 50.771605 Tz (are ) Tj 0.991667 0 Td 55.902778 Tz (each ) Tj 1.477778 0 Td 59.953704 Tz (combined ) Tj 2.955556 0 Td 48.611111 Tz (to ) Tj 0.719444 0 Td 55.555556 Tz (produce ) Tj 2.430556 0 Td 51.203704 Tz (pathologic ) Tj 3.188889 0 Td 59.41358 Tz (and ) Tj 1.186111 0 Td 50.925926 Tz (healthy ) Tj 48.571429 0 0 48.571429 0 2479 Tm 26.785294 0 Td 54.044118 Tz (data ) Tj 1.482353 0 Td 43.235294 Tz (sets. ) Tj 1.502941 0 Td 51.470588 Tz (In ) Tj 0.802941 0 Td 67.769608 Tz (some ) Tj 1.791176 0 Td 60.334967 Tz (embodiments, ) Tj 4.508824 0 Td 58.333333 Tz (each ) Tj 1.605882 0 Td 53.186275 Tz (data ) Tj 1.461765 0 Td 46.895425 Tz (set ) Tj 0.988235 0 Td 42.892157 Tz (is ) Tj 0.720588 0 Td 54.590018 Tz (normalized. ) Tj 51.428571 0 0 51.428571 0 2435.554974 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.816667 0 Td 46.990741 Tz (step ) Tj 1.361111 0 Td 55.092593 Tz (S116, ) Tj 1.866667 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 48.611111 Tz (feature ) Tj 2.255556 0 Td 49.074074 Tz (vectors ) Tj 2.275 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 47.222222 Tz (further ) Tj 2.138889 0 Td 53.652263 Tz (processed ) Tj 3.091667 0 Td 59.953704 Tz (by ) Tj 51.428571 0 0 51.428571 0 2393.934132 Tm 25.277778 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 48.251029 Tz (principal ) Tj 2.8 0 Td 58.009259 Tz (components ) Tj 3.675 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 62.87037 Tz (\(PCA\) ) Tj 2.061111 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 59.548611 Tz (maximize ) Tj 3.013889 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2347.894207 Tm 25.316667 0 Td 52.391975 Tz (spread ) Tj 2.158333 0 Td 55.092593 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (data ) Tj 1.458333 0 Td 49.151235 Tz (points ) Tj 2.041667 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.8107 Tz (resultant ) Tj 2.8 0 Td 52.662037 Tz (multidimensional ) Tj 51.428571 0 0 51.428571 0 2304.023968 Tm 25.316667 0 Td 51.131687 Tz (\(reduced\) ) Tj 3.091667 0 Td 47.685185 Tz (feature ) Tj 2.313889 0 Td 48.611111 Tz (space. ) Tj 2.1 0 Td 76.697531 Tz (PCA ) Tj 1.711111 0 Td 37.268519 Tz (is ) Tj 0.777778 0 Td 50.771605 Tz (described ) Tj 3.072222 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 55.092593 Tz (a ) Tj 0.680556 0 Td 46.296296 Tz (variety ) Tj 2.255556 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 2263.240642 Tm 25.297222 0 Td 49.151235 Tz (publications ) Tj 3.966667 0 Td 54.282407 Tz (such ) Tj 1.691667 0 Td 50.231481 Tz (as ) Tj 1.05 0 Td 29.166667 Tz (I. ) Tj 0.758333 0 Td 45.37037 Tz (T. ) Tj 0.972222 0 Td 41.049383 Tz (Jolliffe, ) Tj 2.644444 0 Td 47.530864 Tz (Principal ) Tj 2.975 0 Td 63.374486 Tz (Component ) Tj 51.428571 0 0 51.428571 0 2216.403509 Tm 25.297222 0 Td 52.662037 Tz (Analysis ) Tj 2.897222 0 Td 52.932099 Tz (\(2d ) Tj 1.283333 0 Td 46.450617 Tz (ed. ) Tj 1.205556 0 Td 56.388889 Tz (2002\) ) Tj 1.983333 0 Td 61.574074 Tz (and ) Tj 1.419444 0 Td 51.851852 Tz (Karl ) Tj 1.652778 0 Td 50.636574 Tz (Pearson, ) Tj 2.761111 0 Td 66.975309 Tz (On ) Tj 1.575 0 Td 55.092593 Tz (Line ) Tj 1.613889 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2173.343542 Tm 25.316667 0 Td 51.851852 Tz (Planes ) Tj 2.138889 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 51.388889 Tz (Closest ) Tj 2.430556 0 Td 45.37037 Tz (Fit ) Tj 1.069444 0 Td 42.12963 Tz (to ) Tj 0.816667 0 Td 57.407407 Tz (Systems ) Tj 2.663889 0 Td 59.953704 Tz (of ) Tj 0.894444 0 Td 49.691358 Tz (Points ) Tj 2.061111 0 Td 45.37037 Tz (in ) Tj 0.855556 0 Td 51.851852 Tz (Space. ) Tj 2.430556 0 Td 50.231481 Tz (2\(6\) ) Tj 51.428571 0 0 51.428571 0 2130.346841 Tm 25.297222 0 Td 50.605413 Tz (Philosophical ) Tj 4.161111 0 Td 59.953704 Tz (Magazine ) Tj 3.052778 0 Td 57.253086 Tz (559-72 ) Tj 2.294444 0 Td 49.537037 Tz (\(1901\). ) Tj 2.255556 0 Td 64.814815 Tz (The ) Tj 1.361111 0 Td 46.450617 Tz (resultant ) Tj 2.702778 0 Td 55.740741 Tz (lower ) Tj 51.428571 0 0 51.428571 0 2086.15534 Tm 25.297222 0 Td 51.388889 Tz (dimensionality ) Tj 4.511111 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 47.685185 Tz (feature ) Tj 2.216667 0 Td 48.611111 Tz (vectors ) Tj 2.236111 0 Td 55.092593 Tz (can ) Tj 1.244444 0 Td 64.00463 Tz (make ) Tj 1.730556 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 44.074074 Tz (classifier ) Tj 40 0 0 40 0 2048 Tm 32.575 0 Td 78.125 Tz (more ) Tj 2.075 0 Td 56.944444 Tz (efficient ) Tj 3.3 0 Td 75 Tz (and ) Tj 1.6 0 Td 80.208333 Tz (more ) Tj 2.175 0 Td 55.952381 Tz (stable. ) Tj 51.428571 0 0 51.428571 0 1996.605128 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.758333 0 Td 47.800926 Tz (step ) Tj 1.341667 0 Td 55.092593 Tz (S118, ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 45.37037 Tz (linear ) Tj 1.808333 0 Td 50.771605 Tz (discriminant ) Tj 3.791667 0 Td 49.421296 Tz (function ) Tj 2.566667 0 Td 61.574074 Tz (\(LDF\) ) Tj 2.022222 0 Td 55.092593 Tz (such ) Tj 1.477778 0 Td 51.851852 Tz (as ) Tj 51.428571 0 0 51.428571 0 1954.249032 Tm 25.316667 0 Td 48.206019 Tz (Fisher's ) Tj 2.644444 0 Td 45.910494 Tz (linear ) Tj 1.925 0 Td 50.771605 Tz (discriminant ) Tj 3.947222 0 Td 49.826389 Tz (function ) Tj 2.702778 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 55.902778 Tz (used ) Tj 1.613889 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 56.018519 Tz (produce ) Tj 2.644444 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1912.617391 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 4.083333 0 Td 51.851852 Tz (algorithm ) Tj 3.130556 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 54.166667 Tz (reduced ) Tj 2.586111 0 Td 50.925926 Tz (dimensionality ) Tj 4.608333 0 Td 76.157407 Tz (FD ) Tj 51.428571 0 0 51.428571 0 1867.947368 Tm 25.297222 0 Td 44.722222 Tz (data. ) Tj 1.594444 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 46.180556 Tz (role ) Tj 1.322222 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 53.472222 Tz (an ) Tj 0.933333 0 Td 74.537037 Tz (LDF ) Tj 1.575 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 45.37037 Tz (to ) Tj 0.758333 0 Td 52.777778 Tz (provide ) Tj 2.430556 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 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25.297222 0 Td 51.851852 Tz (criminant ) Tj 3.111111 0 Td 49.691358 Tz (functions ) Tj 3.013889 0 Td 49.691358 Tz (are ) Tj 1.205556 0 Td 51.851852 Tz (described ) Tj 3.111111 0 Td 46.990741 Tz (in ) Tj 0.894444 0 Td 49.151235 Tz (publications ) Tj 3.869444 0 Td 55.092593 Tz (such ) Tj 1.652778 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 1693.519231 Tm 25.297222 0 Td 53.877315 Tz (Geoffrey ) Tj 2.780556 0 Td 37.268519 Tz (J. ) Tj 0.680556 0 Td 58.009259 Tz (McLachlan, ) Tj 3.713889 0 Td 52.391975 Tz (Discriminant ) Tj 3.947222 0 Td 52.256944 Tz (Analysis ) Tj 2.722222 0 Td 90.740741 Tz (& ) Tj 0.777778 0 Td 43.013468 Tz (Statistical ) Tj 52.857143 0 0 52.857143 0 1649.673469 Tm 24.613514 0 Td 47.297297 Tz (Pattern ) Tj 2.213514 0 Td 51.597052 Tz (Recognition ) Tj 3.613514 0 Td 48.198198 Tz (\(1992\). ) Tj 51.428571 0 0 51.428571 0 1604.427873 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.7 0 Td 64.814815 Tz (some ) Tj 1.672222 0 Td 56.712963 Tz (embodiments, ) Tj 4.2 0 Td 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6.358333 0 Td 48.611111 Tz (gies ) Tj 1.341667 0 Td 66.975309 Tz (may ) Tj 1.361111 0 Td 44.830247 Tz (differ ) Tj 1.711111 0 Td 57.523148 Tz (from ) Tj 1.516667 0 Td 55.812757 Tz (glaucoma, ) Tj 3.130556 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 44.907407 Tz (classification ) Tj 3.908333 0 Td 52.211934 Tz (algorithm ) Tj 2.955556 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2305.244284 Tm 6.338889 0 Td 48.611111 Tz (trained ) Tj 2.236111 0 Td 52.777778 Tz (without ) Tj 2.352778 0 Td 59.41358 Tz (knowledge ) Tj 3.402778 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 50.673401 Tz (physiology, ) Tj 3.519444 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 46.585648 Tz (instead, ) Tj 2.411111 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 2261.598854 Tm 6.358333 0 Td 53.472222 Tz (only ) Tj 1.477778 0 Td 55.452675 Tz (concerned ) Tj 3.169444 0 Td 53.472222 Tz (with ) Tj 1.477778 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 47.685185 Tz (pattern ) Tj 2.177778 0 Td 52.211934 Tz (presented ) Tj 2.994444 0 Td 45.37037 Tz (in ) Tj 0.719444 0 Td 51.851852 Tz (the ) Tj 1.088889 0 Td 46.018519 Tz (data. ) Tj 51.428571 0 0 51.428571 0 2220.491124 Tm 6.377778 0 Td 58.333333 Tz (System ) Tj 2.275 0 Td 47.530864 Tz (for ) Tj 0.972222 0 Td 51.851852 Tz (Detecting ) Tj 2.897222 0 Td 52.932099 Tz (and/or ) Tj 2.022222 0 Td 49.583333 Tz (Predicting ) Tj 3.091667 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 51.557239 Tz (Progression ) Tj 3.538889 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 59.143519 Tz (Reti ) Tj 51.428571 0 0 51.428571 0 2177.341014 Tm 6.358333 0 Td 48.611111 Tz (nal ) Tj 1.108333 0 Td 50.673401 Tz (Pathologies ) Tj 51.428571 0 0 51.428571 0 2130.917526 Tm 7.116667 0 Td 50.771605 Tz (Referring ) Tj 2.916667 0 Td 65.895062 Tz (now ) Tj 1.380556 0 Td 45.37037 Tz (to ) Tj 0.719444 0 Td 54.282407 Tz (FIG. ) Tj 1.477778 0 Td 42.12963 Tz (5, ) Tj 0.680556 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 55.092593 Tz (system ) Tj 2.158333 0 Td 59.41358 Tz (500 ) Tj 1.225 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 49.331276 Tz (detecting ) Tj 2.780556 0 Td 52.932099 Tz (and/or ) Tj 51.428571 0 0 51.428571 0 2090.326733 Tm 6.358333 0 Td 49.259259 Tz (predicting ) Tj 3.208333 0 Td 51.851852 Tz (a ) Tj 0.563889 0 Td 51.262626 Tz (progression ) Tj 3.655556 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 43.981481 Tz (retinal ) Tj 2.1 0 Td 50.673401 Tz (pathologies ) Tj 3.636111 0 Td 37.268519 Tz (is ) Tj 0.7 0 Td 50.771605 Tz (provided. ) Tj 51.428571 0 0 51.428571 0 2042.188034 Tm 6.358333 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 55.092593 Tz (system ) Tj 2.158333 0 Td 50.231481 Tz (includes ) Tj 2.566667 0 Td 56.712963 Tz (an ) Tj 0.855556 0 Td 56.481481 Tz (imaging ) Tj 2.527778 0 Td 52.391975 Tz (device ) Tj 2.022222 0 Td 59.41358 Tz (502 ) Tj 1.244444 0 Td 58.333333 Tz (and ) Tj 1.186111 0 Td 55.092593 Tz (a ) Tj 0.486111 0 Td 52.932099 Tz (device ) Tj 2.022222 0 Td 60.493827 Tz (504 ) Tj 51.428571 0 0 51.428571 0 2002.861361 Tm 6.358333 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 56.17284 Tz (implementing ) Tj 4.238889 0 Td 58.333333 Tz (one ) Tj 1.225 0 Td 51.851852 Tz (or ) Tj 0.797222 0 Td 62.384259 Tz (more ) Tj 1.672222 0 Td 45.138889 Tz (classification ) Tj 3.966667 0 Td 49.494949 Tz (algorithms. ) Tj 51.428571 0 0 51.428571 0 1959.332026 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.341667 0 Td 56.481481 Tz (imaging ) Tj 2.586111 0 Td 52.391975 Tz (device ) Tj 2.1 0 Td 59.41358 Tz (502 ) Tj 1.302778 0 Td 54.012346 Tz (can ) Tj 1.186111 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 46.759259 Tz (variety ) Tj 2.158333 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 51.58179 Tz (conventional ) Tj 51.428571 0 0 51.428571 0 1919.583942 Tm 6.358333 0 Td 54.166667 Tz (ophthalmologic ) Tj 4.802778 0 Td 50.462963 Tz (devices ) Tj 2.352778 0 Td 52.777778 Tz (capable ) Tj 2.430556 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 56.944444 Tz (imaging ) Tj 2.586111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 74.537037 Tz (RNFL ) Tj 2.022222 0 Td 55.902778 Tz (Such ) Tj 51.428571 0 0 51.428571 0 1878.294416 Tm 6.358333 0 Td 50.231481 Tz (as ) Tj 0.913889 0 Td 54.282407 Tz (Scanning ) Tj 2.897222 0 Td 46.666667 Tz (laser ) Tj 1.672222 0 Td 50.501543 Tz (polarimeters ) Tj 3.986111 0 Td 68.055556 Tz (\(GDX ) Tj 1.944444 0 Td 49.826389 Tz (devices\) ) Tj 2.702778 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 47.222222 Tz (optical ) Tj 51.428571 0 0 51.428571 0 1835.339901 Tm 6.358333 0 Td 54.73251 Tz (coherence ) Tj 3.247222 0 Td 56.712963 Tz (tomographs ) Tj 3.675 0 Td 56.944444 Tz (\(OCTs\), ) Tj 2.663889 0 Td 52.391975 Tz (and/or ) Tj 2.119444 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 53.148148 Tz (Heidelberg ) Tj 3.480556 0 Td 45.37037 Tz (retina ) Tj 51.428571 0 0 51.428571 0 1795.783784 Tm 6.338889 0 Td 57.361111 Tz (tomographs ) Tj 3.655556 0 Td 55.092593 Tz (\(HRTs\). ) Tj 51.428571 0 0 51.428571 0 1751.908163 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.341667 0 Td 52.391975 Tz (device ) Tj 2.080556 0 Td 62.654321 Tz (504 ) Tj 1.361111 0 Td 46.450617 Tz (for ) Tj 1.05 0 Td 56.17284 Tz (implementing ) Tj 4.258333 0 Td 51.851852 Tz (the ) Tj 1.108333 0 Td 45.138889 Tz (classification ) Tj 4.025 0 Td 62.384259 Tz (algo ) Tj 51.428571 0 0 51.428571 0 1710.257477 Tm 6.358333 0 Td 51.851852 Tz (rithm ) Tj 1.847222 0 Td 43.209877 Tz (\(s\) ) Tj 1.030556 0 Td 54.012346 Tz (can ) Tj 1.263889 0 Td 58.333333 Tz (be ) Tj 0.952778 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 46.759259 Tz (variety ) Tj 2.236111 0 Td 58.333333 Tz (of ) Tj 0.836111 0 Td 47.962963 Tz (electronic ) Tj 3.169444 0 Td 50.925926 Tz (devices ) Tj 2.391667 0 Td 53.703704 Tz (capable ) Tj 2.508333 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 1669.603865 Tm 6.358333 0 Td 54.768519 Tz (performing ) Tj 3.519444 0 Td 54.012346 Tz (mathematical ) Tj 4.141667 0 Td 46.367521 Tz (calculations. ) Tj 3.908333 0 Td 55.092593 Tz (For ) Tj 1.166667 0 Td 55.497685 Tz (example, ) Tj 2.877778 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 72.376543 Tz (gen ) Tj 52.857143 0 0 52.857143 0 1628.885167 Tm 6.186486 0 Td 44.144144 Tz (eral ) Tj 1.210811 0 Td 53.603604 Tz (purpose ) Tj 2.421622 0 Td 56.362613 Tz (computer ) Tj 2.818919 0 Td 54.654655 Tz (can ) Tj 1.154054 0 Td 56.756757 Tz (be ) Tj 0.813514 0 Td 60.855856 Tz (programmed ) Tj 3.783784 0 Td 47.297297 Tz (to ) Tj 0.756757 0 Td 56.056056 Tz (implement ) Tj 3.159459 0 Td 49.399399 Tz (the ) Tj 51.428571 0 0 51.428571 0 1584.95814 Tm 6.358333 0 Td 57.87037 Tz (methods ) Tj 2.586111 0 Td 51.49177 Tz (described ) Tj 2.877778 0 Td 50.231481 Tz (herein ) Tj 1.925 0 Td 53.703704 Tz (through ) Tj 2.391667 0 Td 48.611111 Tz (software. ) Tj 2.761111 0 Td 46.759259 Tz (Alternatively, ) Tj 4.044444 0 Td 49.691358 Tz (the ) Tj 40 0 0 40 0 1548 Tm 8.225 0 Td 73.809524 Tz (methods ) Tj 3.55 0 Td 66.203704 Tz (described ) Tj 3.975 0 Td 65.277778 Tz (herein ) Tj 2.775 0 Td 70.833333 Tz (can ) Tj 1.725 0 Td 72.916667 Tz (be ) Tj 1.3 0 Td 74.404762 Tz (encoded ) Tj 3.55 0 Td 67.708333 Tz (onto ) Tj 2.025 0 Td 73.4375 Tz (hardware ) Tj 40 0 0 40 0 1507 Tm 8.175 0 Td 67.361111 Tz (and/or ) Tj 2.65 0 Td 69.791667 Tz (firmware ) Tj 3.575 0 Td 61.979167 Tz (devices. ) Tj 51.428571 0 0 51.428571 0 1458.122421 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.894444 0 Td 64.00463 Tz (some ) Tj 1.847222 0 Td 56.983025 Tz (embodiments, ) Tj 4.433333 0 Td 49.691358 Tz (the ) Tj 1.186111 0 Td 55.092593 Tz (system ) Tj 2.333333 0 Td 61.574074 Tz (500 ) Tj 1.419444 0 Td 50.231481 Tz (includes ) Tj 2.722222 0 Td 55.092593 Tz (a ) Tj 0.680556 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1417.577114 Tm 6.358333 0 Td 47.170782 Tz (interface ) Tj 2.780556 0 Td 60.493827 Tz (506 ) Tj 1.322222 0 Td 52.5 Tz (configured ) Tj 3.402778 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 59.511785 Tz (communicate ) Tj 4.180556 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 52.391975 Tz (output ) Tj 2.138889 0 Td 58.333333 Tz (of ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1376.611825 Tm 6.358333 0 Td 45.138889 Tz (classification ) Tj 4.083333 0 Td 49.907407 Tz (algorithm. ) Tj 3.305556 0 Td 84.259259 Tz (A ) Tj 0.836111 0 Td 46.296296 Tz (variety ) Tj 2.255556 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 50 Tz (devices ) Tj 2.430556 0 Td 56.17284 Tz (can ) Tj 1.283333 0 Td 59.953704 Tz (be ) Tj 1.011111 0 Td 56.712963 Tz (used ) Tj 51.428571 0 0 51.428571 0 1337.544365 Tm 6.358333 0 Td 51.49177 Tz (including ) Tj 2.936111 0 Td 46.296296 Tz (optical ) Tj 2.138889 0 Td 50.925926 Tz (devices ) Tj 2.333333 0 Td 39.969136 Tz (\(e.g., ) Tj 1.613889 0 Td 77.777778 Tz (CRT ) Tj 1.555556 0 Td 46.8107 Tz (displays, ) Tj 2.722222 0 Td 79.938272 Tz (LCD ) Tj 1.594444 0 Td 47.170782 Tz (displays, ) Tj 51.428571 0 0 51.428571 0 1294.116883 Tm 6.377778 0 Td 77.777778 Tz (LED ) Tj 1.497222 0 Td 47.170782 Tz (displays, ) Tj 2.663889 0 Td 44.650206 Tz (printers, ) Tj 2.527778 0 Td 59.41358 Tz (and ) Tj 1.147222 0 Td 50.771605 Tz (the ) Tj 1.011111 0 Td 44.722222 Tz (like\) ) Tj 1.438889 0 Td 58.333333 Tz (and ) Tj 1.147222 0 Td 51.388889 Tz (audible ) Tj 2.294444 0 Td 50.462963 Tz (devices ) Tj 2.236111 0 Td 40.509259 Tz (\(e.g., ) Tj 51.428571 0 0 51.428571 0 1254.2 Tm 6.377778 0 Td 51.041667 Tz (speakers ) Tj 2.8 0 Td 59.41358 Tz (and ) Tj 1.4 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 40.509259 Tz (like\). ) Tj 1.788889 0 Td 50.771605 Tz (Additionally ) Tj 3.986111 0 Td 55.092593 Tz (or ) Tj 0.933333 0 Td 44.675926 Tz (alternatively, ) Tj 4.102778 0 Td 51.041667 Tz (data ) Tj 40 0 0 40 0 1216 Tm 8.175 0 Td 60.648148 Tz (interface ) Tj 3.575 0 Td 79.166667 Tz (506 ) Tj 1.775 0 Td 70.833333 Tz (can ) Tj 1.65 0 Td 76.515152 Tz (communicate ) Tj 5.375 0 Td 63.888889 Tz (the ) Tj 1.5 0 Td 57.738095 Tz (results ) Tj 2.8 0 Td 56.25 Tz (to ) Tj 1.05 0 Td 75 Tz (one ) Tj 1.725 0 Td 64.583333 Tz (or ) Tj 1.125 0 Td 79.166667 Tz (more ) Tj 51.428571 0 0 51.428571 0 1169.84 Tm 6.358333 0 Td 48.611111 Tz (external ) Tj 2.663889 0 Td 50.462963 Tz (devices ) Tj 2.430556 0 Td 61.574074 Tz (508 ) Tj 1.4 0 Td 55.092593 Tz (Such ) Tj 1.613889 0 Td 51.851852 Tz (as ) Tj 0.933333 0 Td 55.092593 Tz (a ) Tj 0.602778 0 Td 51.388889 Tz (general ) Tj 2.469444 0 Td 55.092593 Tz (purpose ) Tj 2.625 0 Td 57.523148 Tz (computer ) Tj 51.428571 0 0 51.428571 0 1125.866667 Tm 6.358333 0 Td 52.391975 Tz (and/or ) Tj 2.002778 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 49.331276 Tz (database. ) Tj 2.858333 0 Td 59.143519 Tz (Such ) Tj 1.594444 0 Td 57.834758 Tz (communication ) Tj 4.705556 0 Td 54.012346 Tz (can ) Tj 1.127778 0 Td 59.953704 Tz (be ) Tj 0.894444 0 Td 57.744108 Tz (implemented ) Tj 51.428571 0 0 51.428571 0 1087.28866 Tm 6.338889 0 Td 54.166667 Tz (through ) Tj 2.469444 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 46.296296 Tz (variety ) Tj 2.138889 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 55.092593 Tz (wired ) Tj 1.808333 0 Td 60.493827 Tz (and ) Tj 1.283333 0 Td 49.016204 Tz (wireless ) Tj 2.547222 0 Td 47.638889 Tz (protocols. ) Tj 48.571429 0 0 48.571429 0 1043 Tm 7.535294 0 Td 49.754902 Tz (In ) Tj 0.823529 0 Td 67.769608 Tz (some ) Tj 1.811765 0 Td 60.620915 Tz (embodiments, ) Tj 4.591176 0 Td 53.186275 Tz (data ) Tj 1.502941 0 Td 49.56427 Tz (interface ) Tj 2.882353 0 Td 64.052288 Tz (506 ) Tj 1.379412 0 Td 58.333333 Tz (can ) Tj 1.276471 0 Td 54.411765 Tz (include ) Tj 2.491176 0 Td 52.614379 Tz (the ) Tj 51.428571 0 0 51.428571 0 1003.253071 Tm 6.358333 0 Td 50.378788 Tz (appropriate ) Tj 3.538889 0 Td 57.118056 Tz (hardware ) Tj 2.955556 0 Td 52.932099 Tz (and/or ) Tj 2.138889 0 Td 52.256944 Tz (Software ) Tj 2.741667 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 57.613169 Tz (implement ) Tj 3.363889 0 Td 58.333333 Tz (one ) Tj 1.302778 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 961.431918 Tm 6.358333 0 Td 62.384259 Tz (more ) Tj 1.691667 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 52.211934 Tz (following ) Tj 2.994444 0 Td 57.834758 Tz (communication ) Tj 4.686111 0 Td 47.962963 Tz (protocols: ) Tj 51.428571 0 0 51.428571 0 918.110828 Tm 7.077778 0 Td 51.851852 Tz (Universal ) Tj 2.955556 0 Td 46.990741 Tz (Serial ) Tj 1.886111 0 Td 58.333333 Tz (Bus ) Tj 1.244444 0 Td 57.253086 Tz (\(USB\), ) Tj 2.236111 0 Td 76.697531 Tz (USB ) Tj 1.536111 0 Td 45.37037 Tz (2.0, ) Tj 1.283333 0 Td 63.194444 Tz (IEEE ) Tj 1.75 0 Td 51.851852 Tz (1394, ) Tj 1.730556 0 Td 58.873457 Tz (Periph ) Tj 51.428571 0 0 51.428571 0 877.729858 Tm 6.358333 0 Td 45.37037 Tz (eral ) Tj 1.225 0 Td 63.374486 Tz (Component ) Tj 3.597222 0 Td 50.231481 Tz (Interconnect ) Tj 3.772222 0 Td 49.151235 Tz (\(PCI\), ) Tj 1.983333 0 Td 48.251029 Tz (Ethernet, ) Tj 2.761111 0 Td 51.851852 Tz (Gigabit ) Tj 2.391667 0 Td 57.685185 Tz (Ether ) Tj 48.571429 0 0 48.571429 0 835 Tm 6.773529 0 Td 45.465686 Tz (net, ) Tj 1.482353 0 Td 61.764706 Tz (and ) Tj 1.502941 0 Td 52.614379 Tz (the ) Tj 1.338235 0 Td 43.235294 Tz (like. ) Tj 1.667647 0 Td 68.627451 Tz (The ) Tj 1.626471 0 Td 81.20915 Tz (USB ) Tj 1.873529 0 Td 61.764706 Tz (and ) Tj 1.482353 0 Td 82.352941 Tz (USB ) Tj 1.894118 0 Td 54.901961 Tz (2.0 ) Tj 1.338235 0 Td 53.75817 Tz (standards ) Tj 3.294118 0 Td 53.75817 Tz (are ) Tj 51.428571 0 0 51.428571 0 793.87452 Tm 6.358333 0 Td 51.851852 Tz (described ) Tj 3.111111 0 Td 45.37037 Tz (in ) Tj 0.875 0 Td 49.421296 Tz (publications ) Tj 3.869444 0 Td 55.092593 Tz (such ) Tj 1.633333 0 Td 50.231481 Tz (as ) Tj 0.894444 0 Td 63.194444 Tz (Andrew ) Tj 2.663889 0 Td 43.75 Tz (S. ) Tj 0.836111 0 Td 59.305556 Tz (Tanenbaum, ) Tj 51.428571 0 0 51.428571 0 753.243243 Tm 6.377778 0 Td 50.231481 Tz (Structured ) Tj 3.111111 0 Td 61.574074 Tz (Computer ) Tj 3.052778 0 Td 52.121914 Tz (Organization ) Tj 3.908333 0 Td 52.932099 Tz (S3.6.4 ) Tj 2.061111 0 Td 46.990741 Tz (\(5th ) Tj 1.263889 0 Td 46.450617 Tz (ed. ) Tj 0.991667 0 Td 51.851852 Tz (2006\); ) Tj 2.002778 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 711.70632 Tm 6.358333 0 Td 64.274691 Tz (Andrew ) Tj 2.586111 0 Td 45.37037 Tz (S. ) Tj 0.797222 0 Td 58.981481 Tz (Tanenbaum, ) Tj 3.791667 0 Td 63.734568 Tz (Modern ) Tj 2.547222 0 Td 54.012346 Tz (Operating ) Tj 3.169444 0 Td 56.944444 Tz (Systems ) Tj 2.644444 0 Td 58.333333 Tz (32 ) Tj 0.972222 0 Td 55.092593 Tz (\(2d ) Tj 51.428571 0 0 51.428571 0 667 Tm 6.358333 0 Td 47.530864 Tz (ed. ) Tj 1.011111 0 Td 51.311728 Tz (2001\). ) Tj 1.983333 0 Td 65.895062 Tz (The ) Tj 1.302778 0 Td 65.625 Tz (IEEE ) Tj 1.788889 0 Td 57.523148 Tz (1394 ) Tj 1.536111 0 Td 51.041667 Tz (standard ) Tj 2.586111 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 51.131687 Tz (described ) Tj 2.916667 0 Td 48.611111 Tz (in ) Tj 0.661111 0 Td 64.274691 Tz (Andrew ) Tj 2.469444 0 Td 46.990741 Tz (S. ) Tj 51.428571 0 0 51.428571 0 628.753769 Tm 6.358333 0 Td 58.981481 Tz (Tanenbaum, ) Tj 3.830556 0 Td 62.654321 Tz (Modern ) Tj 2.547222 0 Td 54.012346 Tz (Operating ) Tj 3.188889 0 Td 57.407407 Tz (Systems ) Tj 2.663889 0 Td 59.953704 Tz (32 ) Tj 1.011111 0 Td 52.932099 Tz (\(2d ) Tj 1.225 0 Td 46.450617 Tz (ed. ) Tj 1.127778 0 Td 51.311728 Tz (2001\). ) Tj 48.571429 0 0 48.571429 0 586 Tm 6.732353 0 Td 67.48366 Tz (The ) Tj 1.544118 0 Td 65.196078 Tz (PCI ) Tj 1.502941 0 Td 54.473039 Tz (standard ) Tj 2.944118 0 Td 42.892157 Tz (is ) Tj 0.844118 0 Td 54.901961 Tz (described ) Tj 3.273529 0 Td 49.754902 Tz (in ) Tj 0.905882 0 Td 66.911765 Tz (Andrew ) Tj 2.8 0 Td 48.039216 Tz (S. ) Tj 0.905882 0 Td 62.45098 Tz (Tanenbaum, ) Tj 51.428571 0 0 51.428571 0 544.866142 Tm 6.358333 0 Td 63.734568 Tz (Modern ) Tj 2.625 0 Td 53.652263 Tz (Operating ) Tj 3.208333 0 Td 57.407407 Tz (Systems ) Tj 2.741667 0 Td 55.092593 Tz (31 ) Tj 1.030556 0 Td 54.012346 Tz (\(2d ) Tj 1.263889 0 Td 48.611111 Tz (ed. ) Tj 1.225 0 Td 51.311728 Tz (2001\); ) Tj 2.138889 0 Td 63.734568 Tz (Andrew ) Tj 2.644444 0 Td 46.990741 Tz (S. ) Tj 51.428571 0 0 51.428571 0 504.322929 Tm 6.358333 0 Td 58.981481 Tz (Tanenbaum, ) Tj 3.830556 0 Td 50.231481 Tz (Structured ) Tj 3.227778 0 Td 61.574074 Tz (Computer ) Tj 3.169444 0 Td 52.391975 Tz (Organization ) Tj 4.005556 0 Td 50.771605 Tz (91, ) Tj 1.225 0 Td 55.632716 Tz (183-89 ) Tj 51.428571 0 0 51.428571 0 460.104809 Tm 6.377778 0 Td 47.800926 Tz (\(4th ) Tj 1.341667 0 Td 46.450617 Tz (ed. ) Tj 1.127778 0 Td 49.691358 Tz (1999\). ) Tj 1.983333 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 51.041667 Tz (Ethernet ) Tj 2.625 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 51.851852 Tz (Gigabit ) Tj 2.411111 0 Td 50.636574 Tz (Ethernet ) Tj 2.605556 0 Td 50.771605 Tz (standards ) Tj 51.428571 0 0 51.428571 0 419.436385 Tm 6.358333 0 Td 49.691358 Tz (are ) Tj 1.05 0 Td 51.49177 Tz (discussed ) Tj 2.955556 0 Td 45.37037 Tz (in ) Tj 0.661111 0 Td 63.194444 Tz (Andrew ) Tj 2.488889 0 Td 45.37037 Tz (S. ) Tj 0.7 0 Td 59.305556 Tz (Tanenbaum, ) Tj 3.733333 0 Td 61.168981 Tz (Computer ) Tj 3.052778 0 Td 58.738426 Tz (Networks ) Tj 51.428571 0 0 51.428571 0 376 Tm 6.416667 0 Td 47.530864 Tz (17, ) Tj 1.05 0 Td 56.712963 Tz (65-68,271-92 ) Tj 4.297222 0 Td 47.800926 Tz (\(4th ) Tj 1.322222 0 Td 49.691358 Tz (ed. ) Tj 1.088889 0 Td 51.311728 Tz (2003\). ) Tj 48.571429 0 0 48.571429 0 337 Tm 7.535294 0 Td 49.754902 Tz (In ) Tj 0.823529 0 Td 54.215686 Tz (other ) Tj 1.791176 0 Td 60.334967 Tz (embodiments, ) Tj 4.570588 0 Td 54.044118 Tz (data ) Tj 1.523529 0 Td 49.56427 Tz (interface ) Tj 2.923529 0 Td 61.764706 Tz (506 ) Tj 1.338235 0 Td 58.333333 Tz (can ) Tj 1.297059 0 Td 53.921569 Tz (include ) Tj 2.491176 0 Td 52.614379 Tz (the ) Tj 51.428571 0 0 51.428571 0 296.253071 Tm 6.358333 0 Td 50.378788 Tz (appropriate ) Tj 3.538889 0 Td 57.118056 Tz (hardware ) Tj 2.955556 0 Td 52.932099 Tz (and/or ) Tj 2.138889 0 Td 52.256944 Tz (Software ) Tj 2.741667 0 Td 46.990741 Tz (to ) Tj 0.836111 0 Td 57.613169 Tz (implement ) Tj 3.363889 0 Td 58.333333 Tz (one ) Tj 1.302778 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 253.797136 Tm 6.358333 0 Td 62.384259 Tz (more ) Tj 1.691667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 52.211934 Tz (following ) Tj 3.033333 0 Td 57.58547 Tz (communication ) Tj 4.705556 0 Td 47.962963 Tz (protocols: ) Tj 3.130556 0 Td 49.907407 Tz (Bluetooth, ) Tj 48.571429 0 0 48.571429 0 212 Tm 6.752941 0 Td 68.627451 Tz (IEEE ) Tj 1.914706 0 Td 55.392157 Tz (802.11, ) Tj 2.655882 0 Td 68.627451 Tz (IEEE ) Tj 1.935294 0 Td 53.376906 Tz (802.15.4, ) Tj 3.15 0 Td 64.052288 Tz (and ) Tj 1.461765 0 Td 51.470588 Tz (the ) Tj 1.235294 0 Td 43.235294 Tz (like. ) Tj 1.585294 0 Td 67.48366 Tz (The ) Tj 1.523529 0 Td 56.045752 Tz (Bluetooth ) Tj 51.428571 0 0 51.428571 0 169.504359 Tm 6.377778 0 Td 51.041667 Tz (standard ) Tj 2.722222 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 51.131687 Tz (discussed ) Tj 3.033333 0 Td 45.37037 Tz (in ) Tj 0.777778 0 Td 64.274691 Tz (Andrew ) Tj 2.586111 0 Td 46.990741 Tz (S. ) Tj 0.816667 0 Td 59.62963 Tz (Tanenbaum, ) Tj 3.85 0 Td 61.168981 Tz (Computer ) Tj 30 0 0 30 0 2755 Tm 41.833333 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.672973 0 Td 74.099099 Tz (10 ) Tj 51.428571 0 0 51.428571 0 2913 Tm 25.277778 0 Td 59.143519 Tz (Networks ) Tj 2.994444 0 Td 50.771605 Tz (21, ) Tj 1.127778 0 Td 57.253086 Tz (310-17 ) Tj 2.236111 0 Td 48.611111 Tz (\(4th ) Tj 1.361111 0 Td 46.450617 Tz (ed. ) Tj 1.05 0 Td 51.851852 Tz (2003\). ) Tj 2.022222 0 Td 64.814815 Tz (The ) Tj 1.380556 0 Td 64.00463 Tz (IEEE ) Tj 1.691667 0 Td 53.472222 Tz (802.11 ) Tj 2.197222 0 Td 59.143519 Tz (stan ) Tj 51.428571 0 0 51.428571 0 2873.645161 Tm 25.297222 0 Td 54.282407 Tz (dard ) Tj 1.497222 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 51.851852 Tz (discussed ) Tj 2.994444 0 Td 43.75 Tz (in ) Tj 0.680556 0 Td 63.734568 Tz (Andrew ) Tj 2.508333 0 Td 46.990741 Tz (S. ) Tj 0.758333 0 Td 59.305556 Tz (Tanenbaum, ) Tj 3.713889 0 Td 61.979167 Tz (Computer ) Tj 51.428571 0 0 51.428571 0 2830 Tm 25.997222 0 Td 59.143519 Tz (Networks ) Tj 2.955556 0 Td 57.407407 Tz (292-302 ) Tj 2.566667 0 Td 48.611111 Tz (\(4th ) Tj 1.263889 0 Td 46.450617 Tz (ed. ) Tj 0.991667 0 Td 51.311728 Tz (2003\). ) Tj 1.963889 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 64.814815 Tz (IEEE ) Tj 1.652778 0 Td 53.06713 Tz (802.15.4 ) Tj 2.663889 0 Td 59.143519 Tz (stan ) Tj 51.428571 0 0 51.428571 0 2789.938089 Tm 25.297222 0 Td 54.282407 Tz (dard ) Tj 1.633333 0 Td 37.268519 Tz (is ) Tj 0.816667 0 Td 51.131687 Tz (described ) Tj 3.111111 0 Td 43.75 Tz (in ) Tj 0.816667 0 Td 57.79321 Tz (Yu-Kai ) Tj 2.430556 0 Td 64.166667 Tz (Huang ) Tj 2.236111 0 Td 90.740741 Tz (& ) Tj 0.875 0 Td 58.796296 Tz (Ai-Chan ) Tj 2.838889 0 Td 52.5 Tz (Pang, ) Tj 1.905556 0 Td 68.055556 Tz (A ) Tj 51.428571 0 0 51.428571 0 2751.759494 Tm 25.297222 0 Td 58.333333 Tz (Comprehensive ) Tj 4.919444 0 Td 55.740741 Tz (Study ) Tj 2.022222 0 Td 59.953704 Tz (of ) Tj 1.030556 0 Td 62.654321 Tz (Low-Power ) Tj 3.694444 0 Td 54.012346 Tz (Operation ) Tj 3.286111 0 Td 46.990741 Tz (in ) Tj 0.952778 0 Td 64.814815 Tz (IEEE ) Tj 51.428571 0 0 51.428571 0 2705 Tm 25.316667 0 Td 52.572016 Tz (802.15.4 ) Tj 3.033333 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 83.796296 Tz (MSWiM07 ) Tj 3.694444 0 Td 57.253086 Tz (405-08 ) Tj 2.255556 0 Td 49.537037 Tz (\(2007\). ) Tj 51.428571 0 0 51.428571 0 2665.285181 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.738889 0 Td 52.777778 Tz (another ) Tj 2.352778 0 Td 57.744108 Tz (embodiment, ) Tj 3.947222 0 Td 48.611111 Tz (external ) Tj 2.527778 0 Td 49.421296 Tz (data ) Tj 1.380556 0 Td 52.391975 Tz (source ) Tj 2.041667 0 Td 60.493827 Tz (508 ) Tj 1.225 0 Td 52.256944 Tz (provides ) Tj 51.428571 0 0 51.428571 0 2625.126187 Tm 25.277778 0 Td 55.555556 Tz (updated ) Tj 2.858333 0 Td 49.826389 Tz (versions ) Tj 2.955556 0 Td 55.092593 Tz (of ) Tj 1.108333 0 Td 49.691358 Tz (the ) Tj 1.419444 0 Td 44.907407 Tz (classification ) Tj 4.316667 0 Td 49.494949 Tz (algorithms. ) Tj 3.85 0 Td 56.17284 Tz (For ) Tj 51.428571 0 0 51.428571 0 2584.92399 Tm 25.297222 0 Td 54.282407 Tz (example, ) Tj 2.761111 0 Td 49.691358 Tz (the ) Tj 1.05 0 Td 53.472222 Tz (manufacturer ) Tj 3.966667 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 54.012346 Tz (system ) Tj 2.119444 0 Td 59.41358 Tz (500 ) Tj 1.205556 0 Td 55.092593 Tz (can ) Tj 1.127778 0 Td 48.341049 Tz (periodically ) Tj 51.428571 0 0 51.428571 0 2540.861145 Tm 25.297222 0 Td 46.296296 Tz (collect ) Tj 2.119444 0 Td 48.611111 Tz (data ) Tj 1.341667 0 Td 45.37037 Tz (sets ) Tj 1.244444 0 Td 41.049383 Tz (\(e.g., ) Tj 1.652778 0 Td 53.240741 Tz (through ) Tj 2.430556 0 Td 46.8107 Tz (interface ) Tj 2.663889 0 Td 55.902778 Tz (506\) ) Tj 1.497222 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 47.685185 Tz (further ) Tj 2.158333 0 Td 45.37037 Tz (refine ) Tj 51.428571 0 0 51.428571 0 2501.440986 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.322222 0 Td 45.138889 Tz (classification ) Tj 4.2 0 Td 52.572016 Tz (algorithm ) Tj 3.266667 0 Td 58.333333 Tz (and ) Tj 1.458333 0 Td 48.341049 Tz (periodically ) Tj 3.908333 0 Td 55.632716 Tz (push ) Tj 2.430556 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2459.582649 Tm 25.277778 0 Td 55.555556 Tz (updated ) Tj 2.430556 0 Td 51.851852 Tz (algorithm ) Tj 2.916667 0 Td 48.611111 Tz (to ) Tj 0.719444 0 Td 48.611111 Tz (the ) Tj 0.972222 0 Td 54.62963 Tz (systems ) Tj 2.411111 0 Td 59.41358 Tz (500 ) Tj 1.225 0 Td 46.990741 Tz (in ) Tj 0.661111 0 Td 48.935185 Tz (individual ) Tj 3.033333 0 Td 52.175926 Tz (healthcare ) Tj 51.428571 0 0 51.428571 0 2418.357447 Tm 25.297222 0 Td 51.851852 Tz (provider ) Tj 2.625 0 Td 43.344907 Tz (offices. ) Tj 51.428571 0 0 51.428571 0 2377.672751 Tm 26.016667 0 Td 57.118056 Tz (Although ) Tj 2.955556 0 Td 58.981481 Tz (components ) Tj 3.772222 0 Td 51.851852 Tz (502, ) Tj 1.497222 0 Td 52.662037 Tz (504, ) Tj 1.497222 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 61.574074 Tz (506 ) Tj 1.302778 0 Td 50.771605 Tz (are ) Tj 1.147222 0 Td 50.636574 Tz (depicted ) Tj 2.663889 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 2334.5 Tm 25.297222 0 Td 48.611111 Tz (individual ) Tj 3.052778 0 Td 55.976431 Tz (components, ) Tj 3.830556 0 Td 58.333333 Tz (one ) Tj 1.166667 0 Td 51.851852 Tz (or ) Tj 0.738889 0 Td 61.574074 Tz (more ) Tj 1.594444 0 Td 58.657407 Tz (components ) Tj 3.655556 0 Td 56.17284 Tz (can ) Tj 1.108333 0 Td 58.333333 Tz (be ) Tj 0.816667 0 Td 83.179012 Tz (com ) Tj 51.428571 0 0 51.428571 0 2290.926641 Tm 25.277778 0 Td 54.444444 Tz (bined ) Tj 1.886111 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 57.523148 Tz (form ) Tj 1.633333 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 48.611111 Tz (single ) Tj 2.002778 0 Td 48.611111 Tz (device. ) Tj 2.313889 0 Td 53.148148 Tz (Thus, ) Tj 1.866667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 50.05144 Tz (invention ) Tj 2.975 0 Td 72.592593 Tz (encom ) Tj 51.428571 0 0 51.428571 0 2251.805353 Tm 25.297222 0 Td 51.311728 Tz (passes ) Tj 2.041667 0 Td 59.953704 Tz (an ) Tj 0.952778 0 Td 56.944444 Tz (imaging ) Tj 2.586111 0 Td 51.851852 Tz (device ) Tj 2.080556 0 Td 45.37037 Tz (that ) Tj 1.322222 0 Td 56.064815 Tz (implements ) Tj 3.558333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 45.138889 Tz (classification ) Tj 51.428571 0 0 51.428571 0 2208.582524 Tm 25.297222 0 Td 51.527778 Tz (algorithms ) Tj 3.286111 0 Td 51.49177 Tz (described ) Tj 2.936111 0 Td 50.771605 Tz (herein ) Tj 2.002778 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 49.826389 Tz (includes ) Tj 2.547222 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 49.537037 Tz (display ) Tj 2.294444 0 Td 47.530864 Tz (for ) Tj 1.030556 0 Td 66.435185 Tz (view ) Tj 51.428571 0 0 51.428571 0 2167.593193 Tm 25.297222 0 Td 50.771605 Tz (ing ) Tj 1.108333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 44.444444 Tz (results ) Tj 2.080556 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 44.907407 Tz (classification ) Tj 3.966667 0 Td 49.583333 Tz (algorithm. ) Tj 51.428571 0 0 51.428571 0 2127.320273 Tm 25.297222 0 Td 60.185185 Tz (Methods ) Tj 2.722222 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 51.851852 Tz (Detecting ) Tj 3.013889 0 Td 48.611111 Tz (Retinal ) Tj 2.255556 0 Td 50.968013 Tz (Pathologies ) Tj 51.428571 0 0 51.428571 0 2084.90625 Tm 26.036111 0 Td 51.49177 Tz (Referring ) Tj 2.955556 0 Td 64.814815 Tz (now ) Tj 1.380556 0 Td 43.75 Tz (to ) Tj 0.738889 0 Td 53.472222 Tz (FIG. ) Tj 1.477778 0 Td 43.75 Tz (6, ) Tj 0.661111 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 59.41358 Tz (method ) Tj 2.313889 0 Td 58.333333 Tz (600 ) Tj 1.225 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 48.971193 Tz (detecting ) Tj 2.838889 0 Td 43.055556 Tz (retinal ) Tj 51.428571 0 0 51.428571 0 2043.74404 Tm 25.297222 0 Td 50.673401 Tz (pathologies ) Tj 3.558333 0 Td 40.509259 Tz (is ) Tj 0.661111 0 Td 51.131687 Tz (provided. ) Tj 2.994444 0 Td 48.611111 Tz (In ) Tj 0.797222 0 Td 47.800926 Tz (step ) Tj 1.380556 0 Td 55.092593 Tz (S602, ) Tj 1.847222 0 Td 68.703704 Tz (TSNIT ) Tj 2.313889 0 Td 75.347222 Tz (RNFL ) Tj 2.022222 0 Td 49.421296 Tz (data ) Tj 1.419444 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 2000.417722 Tm 25.297222 0 Td 50.411523 Tz (provided. ) Tj 3.033333 0 Td 46.990741 Tz (In ) Tj 0.816667 0 Td 64.814815 Tz (some ) Tj 1.769444 0 Td 57.253086 Tz (embodiments, ) Tj 4.394444 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 68.703704 Tz (TSNIT ) Tj 2.372222 0 Td 75.347222 Tz (RNFL ) Tj 2.061111 0 Td 49.421296 Tz (data ) Tj 1.458333 0 Td 38.888889 Tz (is ) Tj 48.571429 0 0 48.571429 0 1959 Tm 26.785294 0 Td 56.960784 Tz (one-dimensional ) Tj 5.311765 0 Td 48.039216 Tz (data. ) Tj 1.667647 0 Td 49.754902 Tz (In ) Tj 0.761765 0 Td 58.333333 Tz (such ) Tj 1.585294 0 Td 60.334967 Tz (embodiments, ) Tj 4.488235 0 Td 53.75817 Tz (the ) Tj 1.132353 0 Td 65.577342 Tz (one-dimen ) Tj 51.428571 0 0 51.428571 0 1916.053952 Tm 25.316667 0 Td 46.990741 Tz (sional ) Tj 1.963889 0 Td 50.231481 Tz (data ) Tj 1.438889 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 52.932099 Tz (converted ) Tj 3.072222 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 56.712963 Tz (pseudo ) Tj 2.294444 0 Td 54.228395 Tz (two-dimensional ) Tj 5.113889 0 Td 51.041667 Tz (data ) Tj 1.477778 0 Td 46.990741 Tz (in ) Tj 51.428571 0 0 51.428571 0 1874.611399 Tm 25.316667 0 Td 47.800926 Tz (step ) Tj 1.458333 0 Td 60.763889 Tz (S604 ) Tj 1.769444 0 Td 48.611111 Tz (as ) Tj 0.913889 0 Td 51.49177 Tz (described ) Tj 3.052778 0 Td 47.222222 Tz (herein. ) Tj 2.333333 0 Td 43.75 Tz (In ) Tj 0.855556 0 Td 50.555556 Tz (other ) Tj 1.769444 0 Td 56.983025 Tz (embodiments, ) Tj 4.394444 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1833.052109 Tm 25.297222 0 Td 68.703704 Tz (TSNIT ) Tj 2.313889 0 Td 76.157407 Tz (RNFL ) Tj 2.041667 0 Td 50.231481 Tz (data ) Tj 1.438889 0 Td 40.509259 Tz (is ) Tj 0.680556 0 Td 57.253086 Tz (pseudo ) Tj 2.313889 0 Td 54.012346 Tz (two-dimensional ) Tj 5.094444 0 Td 49.421296 Tz (data ) Tj 1.4 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 1795.520388 Tm 25.297222 0 Td 60.493827 Tz (method ) Tj 2.372222 0 Td 54.166667 Tz (proceed ) Tj 2.469444 0 Td 46.180556 Tz (directly ) Tj 2.411111 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 48.611111 Tz (step ) Tj 1.380556 0 Td 54.444444 Tz (S606. ) Tj 51.428571 0 0 51.428571 0 1749.654843 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 48.611111 Tz (step ) Tj 1.438889 0 Td 55.740741 Tz (S606, ) Tj 1.944444 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 43.518519 Tz (fractal ) Tj 2.1 0 Td 55.452675 Tz (dimension ) Tj 3.325 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 49.259259 Tz (calculated ) Tj 3.208333 0 Td 50.231481 Tz (as ) Tj 0.875 0 Td 60.493827 Tz (dis ) Tj 51.428571 0 0 51.428571 0 1709.562982 Tm 25.297222 0 Td 54.012346 Tz (cussed ) Tj 2.158333 0 Td 47.685185 Tz (herein. ) Tj 2.313889 0 Td 45.37037 Tz (In ) Tj 0.816667 0 Td 47.800926 Tz (step ) Tj 1.419444 0 Td 55.092593 Tz (S608, ) Tj 1.925 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 50.231481 Tz (slopes ) Tj 2.061111 0 Td 57.407407 Tz (between ) Tj 2.683333 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 43.981481 Tz (fractal ) Tj 51.428571 0 0 51.428571 0 1666.572792 Tm 25.297222 0 Td 55.092593 Tz (dimensions ) Tj 3.441667 0 Td 50.771605 Tz (are ) Tj 1.011111 0 Td 49.259259 Tz (calculated ) Tj 3.052778 0 Td 51.851852 Tz (as ) Tj 0.758333 0 Td 51.851852 Tz (discussed ) Tj 2.916667 0 Td 46.759259 Tz (herein. ) Tj 2.138889 0 Td 48.611111 Tz (In ) Tj 0.719444 0 Td 48.611111 Tz (step ) Tj 1.322222 0 Td 55.092593 Tz (S610, ) Tj 1.788889 0 Td 55.092593 Tz (a ) Tj 52.857143 0 0 52.857143 0 1625.423669 Tm 24.613514 0 Td 43.918919 Tz (classification ) Tj 3.802703 0 Td 50.800801 Tz (algorithm ) Tj 2.894595 0 Td 37.837838 Tz (is ) Tj 0.586486 0 Td 50 Tz (applied ) Tj 2.194595 0 Td 45.720721 Tz (to ) Tj 0.662162 0 Td 50.45045 Tz (the ) Tj 1.021622 0 Td 42.792793 Tz (fractal ) Tj 1.948649 0 Td 53.288288 Tz (dimensions ) Tj 3.310811 0 Td 45.720721 Tz (to ) Tj 51.428571 0 0 51.428571 0 1584.606516 Tm 25.297222 0 Td 54.012346 Tz (determine ) Tj 3.15 0 Td 56.481481 Tz (whether ) Tj 2.605556 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 49.074074 Tz (subject ) Tj 2.275 0 Td 54.012346 Tz (has ) Tj 1.205556 0 Td 58.333333 Tz (a ) Tj 0.622222 0 Td 43.518519 Tz (retinal ) Tj 2.080556 0 Td 49.907407 Tz (pathology. ) Tj 3.266667 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 1542.985987 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 4.141667 0 Td 52.572016 Tz (algorithm ) Tj 3.227778 0 Td 55.092593 Tz (can ) Tj 1.361111 0 Td 58.333333 Tz (be ) Tj 1.05 0 Td 51.851852 Tz (a ) Tj 0.7 0 Td 44.907407 Tz (classification ) Tj 4.141667 0 Td 52.932099 Tz (algorithm ) Tj 51.428571 0 0 51.428571 0 1500.946903 Tm 25.277778 0 Td 48.611111 Tz (trained ) Tj 2.236111 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 54.444444 Tz (accordance ) Tj 3.461111 0 Td 52.662037 Tz (with ) Tj 1.458333 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 48.611111 Tz (description ) Tj 3.402778 0 Td 46.759259 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 1461.162679 Tm 25.316667 0 Td 51.388889 Tz (Further ) Tj 2.391667 0 Td 59.722222 Tz (Methods ) Tj 2.780556 0 Td 47.890947 Tz (Utilizing ) Tj 2.819444 0 Td 51.388889 Tz (Optical ) Tj 2.391667 0 Td 57.973251 Tz (Coherence ) Tj 3.344444 0 Td 61.898148 Tz (Tomography ) Tj 38.571429 0 0 38.571429 0 1423 Tm 33.755556 0 Td 75.617284 Tz (Data ) Tj 51.428571 0 0 51.428571 0 1374.625166 Tm 26.016667 0 Td 66.435185 Tz (As ) Tj 1.05 0 Td 51.851852 Tz (discussed ) Tj 2.994444 0 Td 50.771605 Tz (herein ) Tj 2.080556 0 Td 45.37037 Tz (in ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 51.388889 Tz (context ) Tj 2.352778 0 Td 61.574074 Tz (of ) Tj 0.875 0 Td 47.800926 Tz (step ) Tj 1.419444 0 Td 53.796296 Tz (S102, ) Tj 1.925 0 Td 59.953704 Tz (method ) Tj 51.428571 0 0 51.428571 0 1334.862291 Tm 25.336111 0 Td 57.253086 Tz (100 ) Tj 1.341667 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 59.953704 Tz (be ) Tj 0.991667 0 Td 45.775463 Tz (utilized ) Tj 2.469444 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 52.146465 Tz (conjunction ) Tj 3.752778 0 Td 52.662037 Tz (with ) Tj 1.555556 0 Td 46.759259 Tz (optical ) Tj 2.255556 0 Td 54.73251 Tz (coherence ) Tj 51.428571 0 0 51.428571 0 1294.116505 Tm 25.277778 0 Td 58.657407 Tz (tomography ) Tj 3.694444 0 Td 44.722222 Tz (data. ) Tj 1.575 0 Td 50.411523 Tz (Referring ) Tj 2.877778 0 Td 65.895062 Tz (now ) Tj 1.380556 0 Td 43.75 Tz (to ) Tj 0.7 0 Td 57.037037 Tz (FIGS. ) Tj 1.886111 0 Td 74.537037 Tz (7A ) Tj 1.011111 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 57.253086 Tz (7B, ) Tj 1.166667 0 Td 48.148148 Tz (further ) Tj 51.428571 0 0 51.428571 0 1253.581913 Tm 25.297222 0 Td 57.87037 Tz (methods ) Tj 2.858333 0 Td 58.333333 Tz (700 ) Tj 1.438889 0 Td 59.953704 Tz (of ) Tj 0.991667 0 Td 48.316498 Tz (identifying ) Tj 3.519444 0 Td 55.092593 Tz (a ) Tj 0.758333 0 Td 43.055556 Tz (retinal ) Tj 2.197222 0 Td 53.652263 Tz (pathology ) Tj 3.286111 0 Td 44.650206 Tz (utilizing ) Tj 51.428571 0 0 51.428571 0 1210.638596 Tm 25.297222 0 Td 46.616809 Tz (multi-fractal ) Tj 3.791667 0 Td 47.395833 Tz (features ) Tj 2.411111 0 Td 57.523148 Tz (from ) Tj 1.536111 0 Td 47.222222 Tz (optical ) Tj 2.119444 0 Td 54.73251 Tz (coherence ) Tj 3.072222 0 Td 58.333333 Tz (tomography ) Tj 3.655556 0 Td 49.691358 Tz (are ) Tj 51.428571 0 0 51.428571 0 1174 Tm 25.297222 0 Td 50.411523 Tz (provided. ) Tj 51.428571 0 0 51.428571 0 1126.341176 Tm 26.016667 0 Td 51.851852 Tz (In ) Tj 0.991667 0 Td 47.800926 Tz (step ) Tj 1.536111 0 Td 55.740741 Tz (S702, ) Tj 2.061111 0 Td 82.098765 Tz (OCT ) Tj 1.866667 0 Td 76.157407 Tz (RNFL ) Tj 2.216667 0 Td 49.421296 Tz (data ) Tj 1.555556 0 Td 40.509259 Tz (is ) Tj 0.875 0 Td 50.411523 Tz (provided. ) Tj 3.169444 0 Td 46.990741 Tz (In ) Tj 0.952778 0 Td 63.194444 Tz (some ) Tj 51.428571 0 0 51.428571 0 1084.01353 Tm 25.297222 0 Td 56.983025 Tz (embodiments, ) Tj 4.316667 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 82.098765 Tz (OCT ) Tj 1.711111 0 Td 75.347222 Tz (RNFL ) Tj 2.022222 0 Td 49.421296 Tz (data ) Tj 1.419444 0 Td 37.268519 Tz (is ) Tj 0.661111 0 Td 52.256944 Tz (obtained ) Tj 2.683333 0 Td 58.333333 Tz (from ) Tj 1.594444 0 Td 47.685185 Tz (optical ) Tj 51.428571 0 0 51.428571 0 1042.696113 Tm 25.297222 0 Td 54.73251 Tz (coherence ) Tj 3.091667 0 Td 58.333333 Tz (tomography ) Tj 3.655556 0 Td 52.932099 Tz (device ) Tj 2.022222 0 Td 54.282407 Tz (such ) Tj 1.458333 0 Td 50.231481 Tz (as ) Tj 0.758333 0 Td 50.771605 Tz (the ) Tj 1.011111 0 Td 75.462963 Tz (STRATUS ) Tj 3.305556 0 Td 71.944444 Tz (OCTTM ) Tj 48.571429 0 0 48.571429 0 1002 Tm 26.785294 0 Td 51.089325 Tz (available ) Tj 2.944118 0 Td 60.906863 Tz (from ) Tj 1.688235 0 Td 54.901961 Tz (Carl ) Tj 1.523529 0 Td 53.529412 Tz (Zeiss ) Tj 1.811765 0 Td 56.617647 Tz (Meditec, ) Tj 2.944118 0 Td 46.323529 Tz (Inc. ) Tj 1.338235 0 Td 60.04902 Tz (of ) Tj 0.864706 0 Td 54.411765 Tz (Dublin, ) Tj 2.470588 0 Td 48.039216 Tz (Calif. ) Tj 51.428571 0 0 51.428571 0 961.38255 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.816667 0 Td 46.990741 Tz (step ) Tj 1.341667 0 Td 55.740741 Tz (S704, ) Tj 1.886111 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 50.231481 Tz (data ) Tj 1.419444 0 Td 45.37037 Tz (set ) Tj 0.991667 0 Td 51.851852 Tz (are ) Tj 1.108333 0 Td 50.771605 Tz (separated ) Tj 2.955556 0 Td 46.180556 Tz (into ) Tj 1.302778 0 Td 55.092593 Tz (a ) Tj 0.563889 0 Td 46.990741 Tz (training ) Tj 2.45 0 Td 45.37037 Tz (set ) Tj 51.428571 0 0 51.428571 0 919.209332 Tm 25.297222 0 Td 58.333333 Tz (and ) Tj 1.205556 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 46.759259 Tz (testing ) Tj 2.119444 0 Td 40.509259 Tz (set. ) Tj 1.147222 0 Td 63.734568 Tz (The ) Tj 1.302778 0 Td 47.800926 Tz (training ) Tj 2.469444 0 Td 44.290123 Tz (set ) Tj 0.991667 0 Td 37.268519 Tz (is ) Tj 0.641667 0 Td 55.902778 Tz (used ) Tj 1.497222 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 44.074074 Tz (train ) Tj 1.497222 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 46.990741 Tz (classifi ) Tj 51.428571 0 0 51.428571 0 878.27791 Tm 25.297222 0 Td 49.691358 Tz (cation ) Tj 1.886111 0 Td 51.851852 Tz (algorithm ) Tj 2.955556 0 Td 53.796296 Tz (while ) Tj 1.711111 0 Td 49.691358 Tz (the ) Tj 0.991667 0 Td 46.296296 Tz (testing ) Tj 2.061111 0 Td 45.37037 Tz (set ) Tj 0.933333 0 Td 37.268519 Tz (is ) Tj 0.602778 0 Td 48.206019 Tz (retained ) Tj 2.430556 0 Td 48.611111 Tz (for ) Tj 0.952778 0 Td 46.759259 Tz (testing ) Tj 2.041667 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 834.468415 Tm 25.297222 0 Td 47.863248 Tz (effectiveness ) Tj 3.927778 0 Td 58.333333 Tz (of ) Tj 0.758333 0 Td 51.851852 Tz (the ) Tj 1.069444 0 Td 49.074074 Tz (trained ) Tj 2.236111 0 Td 44.907407 Tz (classification ) Tj 3.947222 0 Td 49.907407 Tz (algorithm. ) Tj 3.227778 0 Td 46.990741 Tz (In ) Tj 0.758333 0 Td 64.814815 Tz (some ) Tj 48.571429 0 0 48.571429 0 794 Tm 26.785294 0 Td 60.334967 Tz (embodiments, ) Tj 4.529412 0 Td 58.333333 Tz (a ) Tj 0.514706 0 Td 49.945534 Tz (variation ) Tj 2.882353 0 Td 61.764706 Tz (of ) Tj 0.905882 0 Td 51.960784 Tz (10-fold ) Tj 2.347059 0 Td 52.843137 Tz (cross ) Tj 1.791176 0 Td 50.441176 Tz (validation ) Tj 3.252941 0 Td 39.460784 Tz (is ) Tj 0.679412 0 Td 52.156863 Tz (used, ) Tj 51.428571 0 0 51.428571 0 754.405333 Tm 25.297222 0 Td 50.231481 Tz (as ) Tj 0.913889 0 Td 32.407407 Tz (it ) Tj 0.680556 0 Td 38.888889 Tz (is ) Tj 0.758333 0 Td 50.231481 Tz (Superior ) Tj 2.683333 0 Td 45.37037 Tz (to ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 45.37037 Tz (split-half ) Tj 2.955556 0 Td 59.41358 Tz (method ) Tj 2.430556 0 Td 58.333333 Tz (and ) Tj 1.341667 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 48.287037 Tz (especially ) Tj 51.428571 0 0 51.428571 0 713.412422 Tm 25.297222 0 Td 54.552469 Tz (advantageous ) Tj 4.122222 0 Td 64.814815 Tz (when ) Tj 1.769444 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 51.041667 Tz (very ) Tj 1.419444 0 Td 47.962963 Tz (large ) Tj 1.652778 0 Td 56.712963 Tz (sample ) Tj 2.216667 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 50.771605 Tz (not ) Tj 1.088889 0 Td 45.694444 Tz (available. ) Tj 2.975 0 Td 56.17284 Tz (For ) Tj 51.428571 0 0 51.428571 0 671.104987 Tm 25.277778 0 Td 43.75 Tz (this ) Tj 1.361111 0 Td 51.527778 Tz (procedure, ) Tj 3.383333 0 Td 49.691358 Tz (the ) Tj 1.205556 0 Td 50.636574 Tz (majority ) Tj 2.761111 0 Td 56.712963 Tz (of ) Tj 0.875 0 Td 49.537037 Tz (Subject ) Tj 2.372222 0 Td 50.231481 Tz (data ) Tj 1.516667 0 Td 44.560185 Tz (sets ) Tj 1.380556 0 Td 42.12963 Tz (\(in ) Tj 1.088889 0 Td 64.814815 Tz (some ) Tj 51.428571 0 0 51.428571 0 627.133089 Tm 25.297222 0 Td 56.983025 Tz (embodiments, ) Tj 4.258333 0 Td 67.24537 Tz (90%\) ) Tj 1.788889 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 48.206019 Tz (selected ) Tj 2.488889 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 46.990741 Tz (training ) Tj 2.430556 0 Td 41.319444 Tz (set, ) Tj 1.147222 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 586.571779 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 3.986111 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 51.851852 Tz (applied ) Tj 2.333333 0 Td 46.990741 Tz (to ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 51.851852 Tz (Small ) Tj 1.711111 0 Td 43.75 Tz (test ) Tj 1.205556 0 Td 45.37037 Tz (set ) Tj 1.011111 0 Td 48.611111 Tz (consisting ) Tj 3.111111 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 546.66838 Tm 25.297222 0 Td 54.73251 Tz (remaining ) Tj 3.15 0 Td 49.907407 Tz (cases ) Tj 1.711111 0 Td 40.509259 Tz (\(e.g., ) Tj 1.730556 0 Td 55.092593 Tz (10%\). ) Tj 51.428571 0 0 51.428571 0 503.380697 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.855556 0 Td 48.611111 Tz (step ) Tj 1.438889 0 Td 55.740741 Tz (S706, ) Tj 1.944444 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 53.796296 Tz (one-dimensional ) Tj 5.113889 0 Td 49.421296 Tz (data ) Tj 1.477778 0 Td 38.888889 Tz (is ) Tj 0.738889 0 Td 47.727273 Tz (interpreted ) Tj 3.441667 0 Td 43.75 Tz (to ) Tj 51.428571 0 0 51.428571 0 463.233056 Tm 25.297222 0 Td 54.012346 Tz (determine ) Tj 3.091667 0 Td 56.018519 Tz (whether ) Tj 2.488889 0 Td 54.282407 Tz (each ) Tj 1.497222 0 Td 49.074074 Tz (subject ) Tj 2.216667 0 Td 40.509259 Tz (is ) Tj 0.641667 0 Td 51.58179 Tz (pathologic' ) Tj 3.888889 0 Td 53.472222 Tz (or ) Tj 0.777778 0 Td 47.962963 Tz (healthy. ) Tj 51.428571 0 0 51.428571 0 423.16319 Tm 25.316667 0 Td 46.759259 Tz (Interpretation ) Tj 4.161111 0 Td 55.092593 Tz (can ) Tj 1.225 0 Td 51.388889 Tz (include ) Tj 2.391667 0 Td 58.873457 Tz (manual ) Tj 2.333333 0 Td 46.527778 Tz 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0 Td 59.953704 Tz (be ) Tj 0.933333 0 Td 61.279461 Tz (homogeneous ) Tj 4.297222 0 Td 51.851852 Tz (or ) Tj 0.875 0 Td 49.608262 Tz (mono-fractal. ) Tj 4.180556 0 Td 34.027778 Tz (It ) Tj 0.622222 0 Td 54.012346 Tz (has ) Tj 1.225 0 Td 56.712963 Tz (been ) Tj 1.613889 0 Td 49.826389 Tz (reported ) Tj 2.644444 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 1491.994026 Tm 6.338889 0 Td 49.259259 Tz (there ) Tj 1.613889 0 Td 45.37037 Tz (exist ) Tj 1.497222 0 Td 46.367521 Tz (multi-fractal ) Tj 3.772222 0 Td 46.8107 Tz (structure ) Tj 2.663889 0 Td 45.37037 Tz (in ) Tj 0.661111 0 Td 46.180556 Tz (real ) Tj 1.244444 0 Td 56.388889 Tz (world ) Tj 1.808333 0 Td 48.148148 Tz (signals ) Tj 2.158333 0 Td 55.092593 Tz (such ) Tj 1.458333 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 1451.084918 Tm 6.338889 0 Td 59.62963 Tz (tumor ) Tj 2.138889 0 Td 49.537037 Tz (regions ) Tj 2.430556 0 Td 45.37037 Tz (in ) Tj 0.894444 0 Td 64.00463 Tz (MRI. ) Tj 1.905556 0 Td 56.17284 Tz (Hence, ) Tj 2.391667 0 Td 47.193287 Tz (multi-fractional ) Tj 4.919444 0 Td 59.143519 Tz (Brownian ) Tj 51.428571 0 0 51.428571 0 1408.609337 Tm 6.358333 0 Td 56.712963 Tz (motion ) Tj 2.275 0 Td 69.351852 Tz (\(mBm\) ) Tj 2.313889 0 Td 58.981481 Tz (model ) Tj 1.983333 0 Td 66.975309 Tz (may ) Tj 1.419444 0 Td 58.333333 Tz (be ) Tj 0.913889 0 Td 59.953704 Tz (more ) Tj 1.633333 0 Td 47.395833 Tz (suitable ) Tj 2.469444 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 52.146465 Tz (characteriz ) Tj 51.428571 0 0 51.428571 0 1368.811321 Tm 6.358333 0 Td 51.851852 Tz (ing ) Tj 1.166667 0 Td 75.347222 Tz (RNFL ) Tj 1.983333 0 Td 46.018519 Tz (data. ) Tj 40 0 0 40 0 1333 Tm 9.125 0 Td 80.555556 Tz (The ) Tj 1.725 0 Td 111.111111 Tz (mBm ) Tj 2.3 0 Td 47.916667 Tz (is ) Tj 0.825 0 Td 65.47619 Tz (defined ) Tj 2.975 0 Td 64.583333 Tz (as ) Tj 43.571429 0 0 43.571429 0 1253 Tm 9.501639 0 Td 57.029309 Tz (x\(at\)=ax\(t\) ) Tj 17.855738 0 Td 40.801457 Tz (\(4\) ) Tj 51.428571 0 0 51.428571 0 1195.575309 Tm 6.338889 0 Td 60.277778 Tz (where ) Tj 2.022222 0 Td 47.800926 Tz (H\(t\) ) Tj 1.341667 0 Td 38.888889 Tz (is ) Tj 0.661111 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 54.282407 Tz (time ) Tj 1.516667 0 Td 51.388889 Tz (varying ) Tj 2.352778 0 Td 48.611111 Tz (scaling ) Tj 2.216667 0 Td 48.611111 Tz (\(or ) Tj 1.069444 0 Td 52.777778 Tz (Holder\) ) Tj 2.372222 0 Td 52.572016 Tz (exponent, ) Tj 51.428571 0 0 51.428571 0 1152.698366 Tm 6.338889 0 Td 44.560185 Tz (X\(t\) ) Tj 1.244444 0 Td 40.509259 Tz (is ) Tj 0.680556 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 60.493827 Tz (random ) Tj 2.372222 0 Td 49.421296 Tz (process, ) Tj 2.547222 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 40.509259 Tz (is ) Tj 0.661111 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 48.611111 Tz (scaling ) Tj 2.216667 0 Td 43.055556 Tz (factor. ) Tj 51.428571 0 0 51.428571 0 1110.811921 Tm 7.097222 0 Td 51.851852 Tz (After ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.661111 0 Td 54.282407 Tz (mathematical ) Tj 4.238889 0 Td 46.548822 Tz (derivation, ) Tj 3.383333 0 Td 50.771605 Tz (the ) Tj 1.186111 0 Td 50.378788 Tz (expectation ) Tj 3.655556 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 1069.952258 Tm 6.377778 0 Td 54.520697 Tz (squared-magnitude ) Tj 5.736111 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 53.240741 Tz (wavelet ) Tj 2.430556 0 Td 51.49177 Tz (transform ) Tj 2.955556 0 Td 113.425926 Tz (W ) Tj 1.108333 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 43.75 Tz (x\(t\) ) Tj 1.244444 0 Td 38.888889 Tz (is ) Tj 51.428571 0 0 51.428571 0 934.157068 Tm 6.338889 0 Td 60.277778 Tz (where ) Tj 2.041667 0 Td 84.259259 Tz (C ) Tj 0.758333 0 Td 42.12963 Tz (is ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.602778 0 Td 47.170782 Tz (constant. ) Tj 2.819444 0 Td 56.388889 Tz (Then, ) Tj 2.022222 0 Td 47.800926 Tz (H\(t\) ) Tj 1.419444 0 Td 55.092593 Tz (can ) Tj 1.263889 0 Td 58.333333 Tz (be ) Tj 0.952778 0 Td 55.632716 Tz (approximated ) Tj 4.258333 0 Td 50.231481 Tz (as ) Tj 40 0 0 40 0 899 Tm 8.175 0 Td 61.979167 Tz (follows: ) Tj 40.714286 0 0 40.714286 0 771.333333 Tm 15.694737 0 Td 40.935673 Tz (1 ) Tj 13.557895 0 Td 43.664717 Tz (\(6\) ) Tj 22.857143 0 0 22.857143 0 756 Tm 35.39375 0 Td 72.916667 Tz (2 ) Tj 48.857143 0 0 48.857143 0 732.882353 Tm 11.912281 0 Td 37.524366 Tz (lo ) Tj 1.04386 0 Td 68.226121 Tz (N ) Tj 0.634503 0 Td 52.875244 Tz (2. ) Tj 0.961988 0 Td 55.433723 Tz (W\(a, ) Tj 1.555556 0 Td 25.584795 Tz (t\) ) Tj 38.571429 0 0 38.571429 0 689 Tm 10.966667 0 Td 56.17284 Tz (2H\(t\) ) Tj 1.892593 0 Td 77.777778 Tz (= ) Tj 0.881481 0 Td 53.292181 Tz (lim ) Tj 40 0 0 40 0 674 Tm 17.05 0 Td 53.125 Tz (loga ) Tj 51.428571 0 0 51.428571 0 557.428571 Tm 6.377778 0 Td 45.37037 Tz (Finally, ) Tj 2.430556 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 43.981481 Tz (fractal ) Tj 2.1 0 Td 55.812757 Tz (dimension ) Tj 3.286111 0 Td 57.523148 Tz (\(FD\) ) Tj 1.613889 0 Td 56.17284 Tz (can ) Tj 1.244444 0 Td 59.953704 Tz (be ) Tj 0.933333 0 Td 60.358796 Tz (computed ) Tj 3.15 0 Td 52.5 Tz (using ) Tj 51.428571 0 0 51.428571 0 515.558528 Tm 6.377778 0 Td 53.877315 Tz (Equation ) Tj 2.780556 0 Td 58.333333 Tz (3 ) Tj 0.563889 0 Td 48.611111 Tz (as ) Tj 0.797222 0 Td 47.800926 Tz (follows: ) Tj 51.428571 0 0 51.428571 0 380.473024 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.341667 0 Td 59.143519 Tz (main ) Tj 1.633333 0 Td 48.935185 Tz (difference ) Tj 3.130556 0 Td 57.407407 Tz (between ) Tj 2.644444 0 Td 48.611111 Tz (the ) Tj 1.05 0 Td 54.012346 Tz (box-counting ) Tj 4.102778 0 Td 52.572016 Tz (technique ) Tj 51.428571 0 0 51.428571 0 337.389222 Tm 6.358333 0 Td 58.333333 Tz (and ) Tj 1.186111 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 46.990741 Tz (multi-fractional ) Tj 4.725 0 Td 57.928241 Tz (Brownian ) Tj 2.936111 0 Td 52.211934 Tz (technique ) Tj 2.975 0 Td 41.319444 Tz (lies ) Tj 1.127778 0 Td 46.990741 Tz (in ) Tj 0.680556 0 Td 51.851852 Tz (the ) Tj 1.05 0 Td 55.092593 Tz (use ) Tj 1.108333 0 Td 58.333333 Tz (of ) Tj 51.428571 0 0 51.428571 0 296.025189 Tm 6.358333 0 Td 51.851852 Tz (mono-fractals ) Tj 4.472222 0 Td 42.12963 Tz (vs. ) Tj 1.225 0 Td 44.938272 Tz (multi-fractals. ) Tj 4.452778 0 Td 58.981481 Tz (While ) Tj 2.158333 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 54.282407 Tz (box-counting ) Tj 51.428571 0 0 51.428571 0 254.415981 Tm 6.358333 0 Td 61.033951 Tz (method ) Tj 2.333333 0 Td 56.018519 Tz (\(S710a\) ) Tj 2.488889 0 Td 53.472222 Tz (only ) Tj 1.438889 0 Td 47.638889 Tz (calculates ) Tj 3.033333 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 61.898148 Tz (homogenous ) Tj 3.888889 0 Td 60.133745 Tz (mono-frac ) Tj 51.428571 0 0 51.428571 0 211.786408 Tm 6.338889 0 Td 38.078704 Tz (tal, ) Tj 1.108333 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 86.419753 Tz (mBm ) Tj 1.808333 0 Td 59.41358 Tz (method ) Tj 2.333333 0 Td 47.314815 Tz (calculates ) Tj 3.052778 0 Td 46.296296 Tz (multi-fractals ) Tj 4.102778 0 Td 52.5 Tz (using ) Tj 1.769444 0 Td 52.777778 Tz (wavelet ) Tj 40 0 0 40 0 177 Tm 8.175 0 Td 48.4375 Tz (filters. ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.6 0 Td 72.916667 Tz (12 ) Tj 51.428571 0 0 51.428571 0 2915.217722 Tm 26.016667 0 Td 51.851852 Tz (Optionally ) Tj 3.305556 0 Td 46.990741 Tz (in ) Tj 0.758333 0 Td 47.800926 Tz (step ) Tj 1.380556 0 Td 54.552469 Tz (S710c, ) Tj 2.177778 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 43.518519 Tz (fractal ) Tj 2.041667 0 Td 55.092593 Tz (dimensions ) Tj 3.480556 0 Td 53.06713 Tz (obtained ) Tj 51.428571 0 0 51.428571 0 2874.64455 Tm 25.277778 0 Td 54.282407 Tz (with ) Tj 1.477778 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 54.282407 Tz (box-counting ) Tj 4.044444 0 Td 52.211934 Tz (technique ) Tj 2.936111 0 Td 56.481481 Tz (\(S710a\) ) Tj 2.488889 0 Td 49.691358 Tz (are ) Tj 1.011111 0 Td 58.333333 Tz (appended ) Tj 2.955556 0 Td 45.37037 Tz (to ) Tj 0.680556 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2827.602195 Tm 25.297222 0 Td 43.981481 Tz (fractal ) Tj 2.411111 0 Td 54.444444 Tz (dimensions ) Tj 3.811111 0 Td 52.256944 Tz (obtained ) Tj 3.033333 0 Td 52.662037 Tz (with ) Tj 1.847222 0 Td 48.611111 Tz (the ) Tj 1.419444 0 Td 87.5 Tz (mBm ) Tj 2.119444 0 Td 52.572016 Tz (technique ) Tj 51.428571 0 0 51.428571 0 2785.235639 Tm 25.316667 0 Td 51.851852 Tz (\(S710b\). ) Tj 2.625 0 Td 63.734568 Tz (The ) Tj 1.263889 0 Td 54.79798 Tz (combination ) Tj 3.772222 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 54.012346 Tz (box-counting ) Tj 4.005556 0 Td 52.211934 Tz (technique ) Tj 2.955556 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2743.150376 Tm 25.297222 0 Td 88.580247 Tz (mBm ) Tj 1.866667 0 Td 52.572016 Tz (technique ) Tj 3.091667 0 Td 55.092593 Tz (can ) Tj 1.244444 0 Td 57.407407 Tz (enhance ) Tj 2.644444 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 55.976431 Tz (performance ) Tj 3.966667 0 Td 55.092593 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 63.194444 Tz (algo ) Tj 51.428571 0 0 51.428571 0 2699.049628 Tm 25.297222 0 Td 51.851852 Tz (rithm ) Tj 1.808333 0 Td 55.555556 Tz (because ) Tj 2.547222 0 Td 51.851852 Tz (the ) Tj 1.166667 0 Td 51.851852 Tz (techniques ) Tj 3.402778 0 Td 66.975309 Tz (may ) Tj 1.458333 0 Td 60.277778 Tz (complement ) Tj 3.85 0 Td 55.092593 Tz (each ) Tj 1.613889 0 Td 44.290123 Tz (other. ) Tj 51.428571 0 0 51.428571 0 2656.322957 Tm 25.297222 0 Td 63.734568 Tz (The ) Tj 1.477778 0 Td 54.552469 Tz (box-counting ) Tj 4.238889 0 Td 52.932099 Tz (technique ) Tj 3.188889 0 Td 51.041667 Tz (acquires ) Tj 2.819444 0 Td 37.808642 Tz (its ) Tj 1.069444 0 Td 76.157407 Tz (FD ) Tj 1.283333 0 Td 47.395833 Tz (features ) Tj 2.644444 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 2612.958025 Tm 25.297222 0 Td 53.06713 Tz (counting ) Tj 2.741667 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 55.092593 Tz (occupied ) Tj 2.819444 0 Td 55.740741 Tz (boxes ) Tj 1.866667 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 49.826389 Tz (dividing ) Tj 2.547222 0 Td 60.763889 Tz (them ) Tj 1.672222 0 Td 58.333333 Tz (by ) Tj 0.894444 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 82.098765 Tz (mag ) Tj 51.428571 0 0 51.428571 0 2565.501916 Tm 25.297222 0 Td 50.771605 Tz (nitude ) Tj 2.022222 0 Td 43.518519 Tz (factor, ) Tj 2.061111 0 Td 58.981481 Tz (which ) Tj 2.002778 0 Td 40.509259 Tz (is ) Tj 0.719444 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 47.638889 Tz (reciprocal ) Tj 3.091667 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 46.990741 Tz (size ) Tj 1.341667 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 51.851852 Tz (box. ) Tj 51.428571 0 0 51.428571 0 2524.439898 Tm 25.297222 0 Td 53.472222 Tz (This ) Tj 1.555556 0 Td 52.572016 Tz (technique ) Tj 3.091667 0 Td 38.888889 Tz (is ) Tj 0.7 0 Td 49.537037 Tz (closely ) Tj 2.372222 0 Td 46.759259 Tz (related ) Tj 2.216667 0 Td 45.37037 Tz (to ) Tj 0.816667 0 Td 48.611111 Tz (the ) Tj 1.186111 0 Td 58.657407 Tz (morphology ) Tj 3.772222 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2477.879581 Tm 25.316667 0 Td 76.967593 Tz (RNFL ) Tj 2.080556 0 Td 49.421296 Tz (data ) Tj 1.458333 0 Td 35.108025 Tz (\(i.e., ) Tj 1.536111 0 Td 54.444444 Tz (shape ) Tj 1.847222 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 48.611111 Tz (the ) Tj 1.127778 0 Td 43.75 Tz (data\). ) Tj 1.847222 0 Td 72.916667 Tz (On ) Tj 1.127778 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 50.555556 Tz (other ) Tj 1.730556 0 Td 52.5 Tz (hand, ) Tj 1.808333 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2434.383529 Tm 25.297222 0 Td 88.580247 Tz (mBm ) Tj 1.75 0 Td 52.932099 Tz (technique ) Tj 3.033333 0 Td 49.421296 Tz (involves ) Tj 2.527778 0 Td 50.555556 Tz (estimation ) Tj 3.227778 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 43.518519 Tz (fractal ) Tj 1.983333 0 Td 46.234568 Tz (characteristics ) Tj 51.428571 0 0 51.428571 0 2392.053864 Tm 25.297222 0 Td 45.37037 Tz (in ) Tj 0.7 0 Td 48.611111 Tz (multi-resolution ) Tj 4.802778 0 Td 48.611111 Tz (for ) Tj 0.991667 0 Td 49.768519 Tz (non-stationary ) Tj 4.336111 0 Td 44.965278 Tz (signals. ) Tj 2.275 0 Td 50.555556 Tz (Therefore, ) Tj 3.208333 0 Td 63.734568 Tz (sec ) Tj 51.428571 0 0 51.428571 0 2350.501279 Tm 25.297222 0 Td 60.493827 Tz (ond ) Tj 1.361111 0 Td 52.572016 Tz (technique ) Tj 3.15 0 Td 66.975309 Tz (may ) Tj 1.477778 0 Td 58.333333 Tz (be ) Tj 0.991667 0 Td 57.834758 Tz (complementary ) Tj 4.783333 0 Td 46.990741 Tz (to ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 47.800926 Tz (features ) Tj 2.586111 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 2307.372121 Tm 25.297222 0 Td 54.012346 Tz (cannot ) Tj 2.119444 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 50.378788 Tz (represented ) Tj 3.5 0 Td 58.333333 Tz (by ) Tj 0.913889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 54.012346 Tz (box-counting ) Tj 4.044444 0 Td 52.932099 Tz (technique ) Tj 3.033333 0 Td 48.070988 Tz (alone. ) Tj 51.428571 0 0 51.428571 0 2261.477333 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.836111 0 Td 47.800926 Tz (step ) Tj 1.4 0 Td 55.092593 Tz (S712, ) Tj 1.905556 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 72.916667 Tz (FD ) Tj 1.108333 0 Td 47.800926 Tz (features ) Tj 2.527778 0 Td 49.691358 Tz (for ) Tj 1.088889 0 Td 50.87963 Tz (pathologic ) Tj 3.286111 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 50.925926 Tz (healthy ) Tj 51.428571 0 0 51.428571 0 2219.726846 Tm 25.297222 0 Td 46.990741 Tz (patients ) Tj 2.372222 0 Td 50.771605 Tz (are ) Tj 0.991667 0 Td 55.902778 Tz (each ) Tj 1.477778 0 Td 59.953704 Tz (combined ) Tj 2.955556 0 Td 48.611111 Tz (to ) Tj 0.719444 0 Td 55.555556 Tz (produce ) Tj 2.430556 0 Td 51.203704 Tz (pathologic ) Tj 3.188889 0 Td 59.41358 Tz (and ) Tj 1.186111 0 Td 50.925926 Tz (healthy ) Tj 48.571429 0 0 48.571429 0 2173 Tm 26.785294 0 Td 54.044118 Tz (data ) Tj 1.482353 0 Td 43.235294 Tz (sets. ) Tj 1.502941 0 Td 51.470588 Tz (In ) Tj 0.802941 0 Td 67.769608 Tz (some ) Tj 1.791176 0 Td 60.334967 Tz (embodiments, ) Tj 4.508824 0 Td 58.333333 Tz (each ) Tj 1.605882 0 Td 53.186275 Tz (data ) Tj 1.461765 0 Td 46.895425 Tz (set ) Tj 0.988235 0 Td 42.892157 Tz (is ) Tj 0.720588 0 Td 54.590018 Tz (normalized. ) Tj 51.428571 0 0 51.428571 0 2129.554974 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.816667 0 Td 46.990741 Tz (step ) Tj 1.361111 0 Td 55.092593 Tz (S714, ) Tj 1.866667 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 48.611111 Tz (feature ) Tj 2.255556 0 Td 49.074074 Tz (vectors ) Tj 2.275 0 Td 49.691358 Tz (are ) Tj 1.108333 0 Td 47.222222 Tz (further ) Tj 2.138889 0 Td 53.652263 Tz (processed ) Tj 3.091667 0 Td 59.953704 Tz (by ) Tj 51.428571 0 0 51.428571 0 2088.934132 Tm 25.277778 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 48.251029 Tz (principal ) Tj 2.8 0 Td 58.009259 Tz (components ) Tj 3.675 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 62.87037 Tz (\(PCA\) ) Tj 2.061111 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 59.548611 Tz (maximize ) Tj 3.013889 0 Td 50.771605 Tz (the ) Tj 51.428571 0 0 51.428571 0 2041.894207 Tm 25.316667 0 Td 52.391975 Tz (spread ) Tj 2.158333 0 Td 55.092593 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (data ) Tj 1.458333 0 Td 49.151235 Tz (points ) Tj 2.041667 0 Td 45.37037 Tz (in ) Tj 0.816667 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.8107 Tz (resultant ) Tj 2.8 0 Td 52.662037 Tz (multidimensional ) Tj 51.428571 0 0 51.428571 0 1999.030157 Tm 25.316667 0 Td 51.131687 Tz (\(reduced\) ) Tj 2.975 0 Td 47.685185 Tz (feature ) Tj 2.236111 0 Td 49.151235 Tz (space. ) Tj 1.983333 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 45.730453 Tz (resultant ) Tj 2.702778 0 Td 54.444444 Tz (lower ) Tj 1.827778 0 Td 51.62037 Tz (dimensionality ) Tj 40 0 0 40 0 1961 Tm 32.525 0 Td 77.083333 Tz (of ) Tj 1.05 0 Td 63.888889 Tz (the ) Tj 1.425 0 Td 61.904762 Tz (feature ) Tj 2.9 0 Td 63.095238 Tz (vectors ) Tj 2.925 0 Td 72.222222 Tz (can ) Tj 1.625 0 Td 83.333333 Tz (make ) Tj 2.275 0 Td 63.888889 Tz (the ) Tj 1.4 0 Td 56.25 Tz (classifier ) Tj 3.65 0 Td 79.166667 Tz (more ) Tj 2.175 0 Td 56.481481 Tz (efficient ) Tj 40 0 0 40 0 1919 Tm 32.525 0 Td 75 Tz (and ) Tj 1.6 0 Td 80.208333 Tz (more ) Tj 2.175 0 Td 55.952381 Tz (stable. ) Tj 51.428571 0 0 51.428571 0 1870.605128 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.758333 0 Td 47.800926 Tz (step ) Tj 1.341667 0 Td 55.092593 Tz (S716, ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 45.37037 Tz (linear ) Tj 1.808333 0 Td 50.771605 Tz (discriminant ) Tj 3.791667 0 Td 49.421296 Tz (function ) Tj 2.566667 0 Td 61.574074 Tz (\(LDF\) ) Tj 2.022222 0 Td 55.092593 Tz (such ) Tj 1.477778 0 Td 51.851852 Tz (as ) Tj 51.428571 0 0 51.428571 0 1829.249032 Tm 25.316667 0 Td 48.206019 Tz (Fisher's ) Tj 2.644444 0 Td 45.910494 Tz (linear ) Tj 1.925 0 Td 50.771605 Tz (discriminant ) Tj 3.947222 0 Td 49.826389 Tz (function ) Tj 2.702778 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 55.902778 Tz (used ) Tj 1.613889 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 56.018519 Tz (produce ) Tj 2.644444 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1790.617391 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 4.083333 0 Td 51.851852 Tz (algorithm ) Tj 3.130556 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 54.166667 Tz (reduced ) Tj 2.586111 0 Td 50.925926 Tz (dimensionality ) Tj 4.608333 0 Td 76.157407 Tz (FD ) Tj 40 0 0 40 0 1753 Tm 32.525 0 Td 58.333333 Tz (data. ) Tj 51.428571 0 0 51.428571 0 1704.427873 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.7 0 Td 64.814815 Tz (some ) Tj 1.672222 0 Td 56.712963 Tz (embodiments, ) Tj 4.2 0 Td 50.771605 Tz (the ) Tj 1.011111 0 Td 44.907407 Tz (classification ) Tj 3.888889 0 Td 52.572016 Tz (algorithm ) Tj 2.975 0 Td 37.268519 Tz (is ) Tj 0.583333 0 Td 47.530864 Tz (tested ) Tj 51.428571 0 0 51.428571 0 1664.627737 Tm 25.297222 0 Td 61.574074 Tz (on ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 46.296296 Tz (testing ) Tj 2.061111 0 Td 45.37037 Tz (set ) Tj 0.913889 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 46.990741 Tz (step ) Tj 1.283333 0 Td 60.763889 Tz (S718 ) Tj 1.613889 0 Td 45.37037 Tz (to ) Tj 0.661111 0 Td 50.771605 Tz (assure ) Tj 1.925 0 Td 48.611111 Tz (external ) Tj 2.488889 0 Td 45.37037 Tz (validity ) Tj 2.313889 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 52.857143 0 0 52.857143 0 1621.537313 Tm 24.613514 0 Td 43.918919 Tz (classification ) Tj 3.897297 0 Td 48.243243 Tz (algorithm. ) Tj 3.102703 0 Td 81.981982 Tz (A ) Tj 0.718919 0 Td 45.945946 Tz (variety ) Tj 2.118919 0 Td 56.756757 Tz (of ) Tj 0.813514 0 Td 48.648649 Tz (metrics ) Tj 2.251351 0 Td 53.603604 Tz (can ) Tj 1.172973 0 Td 56.756757 Tz (be ) Tj 0.889189 0 Td 53.603604 Tz (used ) Tj 1.456757 0 Td 45.720721 Tz (to ) Tj 51.428571 0 0 51.428571 0 1582.024067 Tm 25.297222 0 Td 49.151235 Tz (assess ) Tj 1.963889 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 53.877315 Tz (accuracy ) Tj 2.8 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 44.907407 Tz (classification ) Tj 3.966667 0 Td 52.211934 Tz (algorithm ) Tj 3.052778 0 Td 50.411523 Tz (including ) Tj 51.428571 0 0 51.428571 0 1537.334911 Tm 25.297222 0 Td 51.041667 Tz (area ) Tj 1.4 0 Td 55.740741 Tz (under ) Tj 1.827778 0 Td 48.206019 Tz (receiver ) Tj 2.469444 0 Td 50.771605 Tz (operating ) Tj 2.916667 0 Td 46.018519 Tz (characteristics ) Tj 4.336111 0 Td 65.219907 Tz (\(AUROC\), ) Tj 3.305556 0 Td 66.975309 Tz (sen ) Tj 51.428571 0 0 51.428571 0 1498.976959 Tm 25.316667 0 Td 39.248971 Tz (sitivity, ) Tj 2.294444 0 Td 43.479938 Tz (specificity, ) Tj 3.305556 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 40.833333 Tz (like. ) Tj 38.571429 0 0 38.571429 0 1423 Tm 38.603704 0 Td 106.584362 Tz (SECOND ) Tj 4.07037 0 Td 110.493827 Tz (WORKING ) Tj 4.925926 0 Td 108.641975 Tz (EXAMPLE ) Tj 51.428571 0 0 51.428571 0 1333.313433 Tm 27.105556 0 Td 51.851852 Tz (Detection ) Tj 2.975 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 62.789352 Tz (Glaucoma ) Tj 3.227778 0 Td 51.851852 Tz (with ) Tj 1.438889 0 Td 50.925926 Tz (Optical ) Tj 2.313889 0 Td 57.973251 Tz (Coherence ) Tj 51.428571 0 0 51.428571 0 1299 Tm 32.180556 0 Td 61.574074 Tz (Tomography ) Tj 51.428571 0 0 51.428571 0 1213.117949 Tm 26.036111 0 Td 53.877315 Tz (Standard ) Tj 2.819444 0 Td 54.166667 Tz (ophthalmologic ) Tj 4.841667 0 Td 57.87037 Tz (machine ) Tj 2.702778 0 Td 51.851852 Tz (output ) Tj 2.1 0 Td 37.268519 Tz (is ) Tj 0.719444 0 Td 49.537037 Tz (usually ) Tj 2.333333 0 Td 66.975309 Tz (pro ) Tj 51.428571 0 0 51.428571 0 1169.913376 Tm 25.297222 0 Td 53.796296 Tz (vided ) Tj 1.925 0 Td 45.37037 Tz (in ) Tj 0.836111 0 Td 53.796296 Tz (terms ) Tj 1.925 0 Td 58.333333 Tz (of ) Tj 0.933333 0 Td 52.256944 Tz (Superior ) Tj 2.741667 0 Td 53.472222 Tz (Average, ) Tj 2.897222 0 Td 46.585648 Tz (Inferior ) Tj 2.469444 0 Td 56.944444 Tz (Average ) Tj 2.663889 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1126.346793 Tm 25.297222 0 Td 57.407407 Tz (Average ) Tj 2.527778 0 Td 54.372428 Tz (Thickness ) Tj 3.091667 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 66.111111 Tz (RNFL. ) Tj 2.119444 0 Td 64.814815 Tz (The ) Tj 1.322222 0 Td 46.180556 Tz (Inferior ) Tj 2.294444 0 Td 56.944444 Tz (Average ) Tj 2.527778 0 Td 40.509259 Tz (is ) Tj 0.622222 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 50.231481 Tz (best ) Tj 51.428571 0 0 51.428571 0 1086.52 Tm 25.297222 0 Td 45.37037 Tz (at ) Tj 0.758333 0 Td 50 Tz (discriminating ) Tj 4.413889 0 Td 59.548611 Tz (glaucoma ) Tj 3.091667 0 Td 57.523148 Tz (from ) Tj 1.633333 0 Td 51.311728 Tz (ocular ) Tj 2.080556 0 Td 56.17284 Tz (normal ) Tj 2.294444 0 Td 48.316498 Tz (individuals ) Tj 51.428571 0 0 51.428571 0 1045.05868 Tm 25.297222 0 Td 53.472222 Tz (followed ) Tj 2.780556 0 Td 61.574074 Tz (by ) Tj 0.952778 0 Td 57.407407 Tz (Average ) Tj 2.625 0 Td 54.372428 Tz (Thickness ) Tj 3.188889 0 Td 58.333333 Tz (and ) Tj 1.302778 0 Td 52.256944 Tz (Superior ) Tj 2.683333 0 Td 57.407407 Tz (Average ) Tj 2.663889 0 Td 53.472222 Tz (with ) Tj 51.428571 0 0 51.428571 0 1003.207154 Tm 25.297222 0 Td 82.314815 Tz (AUROC ) Tj 2.644444 0 Td 55.092593 Tz (being ) Tj 1.827778 0 Td 47.962963 Tz (0.84, ) Tj 1.633333 0 Td 47.962963 Tz (0.76. ) Tj 1.633333 0 Td 58.333333 Tz (and ) Tj 1.244444 0 Td 47.314815 Tz (0.70, ) Tj 1.633333 0 Td 45.868946 Tz (respectively. ) Tj 51.428571 0 0 51.428571 0 961.00128 Tm 26.016667 0 Td 72.916667 Tz (An ) Tj 1.147222 0 Td 54.444444 Tz (experiment ) Tj 3.5 0 Td 61.574074 Tz (was ) Tj 1.380556 0 Td 55.452675 Tz (conducted ) Tj 3.227778 0 Td 45.010288 Tz (utilizing ) Tj 2.722222 0 Td 75.347222 Tz (RNFL ) Tj 2.061111 0 Td 50.05144 Tz (thickness ) Tj 51.428571 0 0 51.428571 0 920.856192 Tm 25.297222 0 Td 49.421296 Tz (data ) Tj 1.497222 0 Td 58.333333 Tz (from ) Tj 1.769444 0 Td 57.253086 Tz (136 ) Tj 1.341667 0 Td 46.585648 Tz (patients ) Tj 2.566667 0 Td 50.771605 Tz (\(63 ) Tj 1.263889 0 Td 52.662037 Tz (with ) Tj 1.575 0 Td 58.738426 Tz (glaucoma ) Tj 3.091667 0 Td 60.493827 Tz (and ) Tj 1.380556 0 Td 56.712963 Tz (73 ) Tj 0.991667 0 Td 55.092593 Tz (having ) Tj 51.428571 0 0 51.428571 0 876.302994 Tm 25.297222 0 Td 57.253086 Tz (normal ) Tj 2.177778 0 Td 51.851852 Tz (ocular ) Tj 1.983333 0 Td 46.666667 Tz (function\). ) Tj 2.994444 0 Td 56.388889 Tz (FIGS. ) Tj 1.827778 0 Td 77.777778 Tz (8A ) Tj 1.030556 0 Td 58.333333 Tz (and ) Tj 1.166667 0 Td 69.675926 Tz (8B ) Tj 1.011111 0 Td 60.763889 Tz (show ) Tj 1.633333 0 Td 49.691358 Tz (the ) Tj 0.991667 0 Td 62.962963 Tz (compari ) Tj 48.571429 0 0 48.571429 0 835 Tm 26.805882 0 Td 57.189542 Tz (son ) Tj 1.194118 0 Td 58.333333 Tz (of ) Tj 0.761765 0 Td 86.928105 Tz (ROC ) Tj 1.688235 0 Td 55.473856 Tz (curves ) Tj 2.141176 0 Td 51.470588 Tz (for ) Tj 1.029412 0 Td 52.843137 Tz (these ) Tj 1.729412 0 Td 51.470588 Tz (three ) Tj 1.688235 0 Td 55.664488 Tz (measures. ) Tj 3.15 0 Td 63.480392 Tz (Note ) Tj 1.667647 0 Td 48.039216 Tz (in ) Tj 0.761765 0 Td 62.745098 Tz (FIG.8A, ) Tj 51.428571 0 0 51.428571 0 796.496487 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 59.953704 Tz (combined ) Tj 2.975 0 Td 54.282407 Tz (box-counting ) Tj 4.005556 0 Td 57.253086 Tz (and ) Tj 1.205556 0 Td 86.419753 Tz (mBm ) Tj 1.691667 0 Td 51.527778 Tz (techniques ) Tj 3.208333 0 Td 55.555556 Tz (perform ) Tj 2.469444 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 752.723404 Tm 25.277778 0 Td 50.231481 Tz (best ) Tj 1.458333 0 Td 66.759259 Tz (among ) Tj 2.275 0 Td 39.969136 Tz (all ) Tj 1.011111 0 Td 48.611111 Tz (three ) Tj 1.730556 0 Td 48.361823 Tz (fractal-based ) Tj 4.044444 0 Td 49.789562 Tz (techniques. ) Tj 3.577778 0 Td 57.523148 Tz (\(The ) Tj 1.672222 0 Td 57.037037 Tz (corre ) Tj 51.428571 0 0 51.428571 0 712.205607 Tm 25.316667 0 Td 55.092593 Tz (sponding ) Tj 2.741667 0 Td 76.157407 Tz (AUROCs ) Tj 2.858333 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 51.602564 Tz (box-counting, ) Tj 4.2 0 Td 72.916667 Tz (mBm, ) Tj 1.886111 0 Td 58.333333 Tz (and ) Tj 1.147222 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 59.953704 Tz (combined ) Tj 51.428571 0 0 51.428571 0 669.048408 Tm 25.277778 0 Td 54.282407 Tz (box-counting ) Tj 4.161111 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 87.5 Tz (mBm ) Tj 1.886111 0 Td 57.87037 Tz (methods ) Tj 2.702778 0 Td 51.851852 Tz (are ) Tj 1.186111 0 Td 47.962963 Tz (0.81, ) Tj 1.730556 0 Td 47.314815 Tz (0.87, ) Tj 1.672222 0 Td 59.41358 Tz (and ) Tj 1.361111 0 Td 47.314815 Tz (0.89, ) Tj 51.428571 0 0 51.428571 0 634 Tm 25.297222 0 Td 46.118234 Tz (respectively. ) Tj 51.428571 0 0 51.428571 0 585.805179 Tm 26.016667 0 Td 59.305556 Tz (Comparison ) Tj 3.713889 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 49.691358 Tz (the ) Tj 1.011111 0 Td 74.537037 Tz (AUROCs ) Tj 2.858333 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 50.231481 Tz (best ) Tj 1.341667 0 Td 48.112536 Tz (fractal-based ) Tj 3.869444 0 Td 60.763889 Tz (tech ) Tj 51.428571 0 0 51.428571 0 542.831039 Tm 25.297222 0 Td 53.796296 Tz (nique ) Tj 1.808333 0 Td 60.493827 Tz (and ) Tj 1.283333 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 44.290123 Tz (set ) Tj 1.011111 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 51.041667 Tz (standard ) Tj 2.683333 0 Td 58.333333 Tz (machine ) Tj 2.683333 0 Td 55.497685 Tz (measures ) Tj 2.897222 0 Td 58.981481 Tz (shows ) Tj 2.022222 0 Td 46.180556 Tz (that ) Tj 51.428571 0 0 51.428571 0 505.743276 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 49.259259 Tz (diagnostic ) Tj 3.208333 0 Td 53.472222 Tz (accuracy ) Tj 2.838889 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 51.851852 Tz (the ) Tj 1.186111 0 Td 59.548611 Tz (combined ) Tj 3.072222 0 Td 54.282407 Tz (box-counting ) Tj 4.122222 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 462.92399 Tm 25.297222 0 Td 88.580247 Tz (mBm ) Tj 1.769444 0 Td 60.493827 Tz (method ) Tj 2.313889 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 45.868946 Tz (significantly ) Tj 3.733333 0 Td 48.611111 Tz (greater ) Tj 2.158333 0 Td 51.041667 Tz (than ) Tj 1.361111 0 Td 51.851852 Tz (the ) Tj 1.011111 0 Td 57.407407 Tz (Average ) Tj 2.527778 0 Td 64.814815 Tz (Thick ) Tj 51.428571 0 0 51.428571 0 422.866407 Tm 25.297222 0 Td 51.851852 Tz (ness ) Tj 1.536111 0 Td 58.333333 Tz (and ) Tj 1.380556 0 Td 52.256944 Tz (Superior ) Tj 2.741667 0 Td 57.407407 Tz (Average ) Tj 2.663889 0 Td 61.574074 Tz (by ) Tj 1.108333 0 Td 70.216049 Tz (13% ) Tj 1.555556 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 69.135802 Tz (19% ) Tj 1.594444 0 Td 48.070988 Tz (respectively ) Tj 51.428571 0 0 51.428571 0 380.216471 Tm 25.316667 0 Td 54.012346 Tz (\(p<0.0001 ) Tj 3.091667 0 Td 59.41358 Tz (and ) Tj 1.166667 0 Td 52.572016 Tz (p=0.001\), ) Tj 2.975 0 Td 56.481481 Tz (whereas ) Tj 2.508333 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 48.935185 Tz (difference ) Tj 3.052778 0 Td 46.990741 Tz (in ) Tj 0.680556 0 Td 49.259259 Tz (diagnostic ) Tj 51.428571 0 0 51.428571 0 339.2723 Tm 25.297222 0 Td 53.472222 Tz (accuracy ) Tj 2.741667 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 46.585648 Tz (Inferior ) Tj 2.333333 0 Td 56.944444 Tz (Average ) Tj 2.508333 0 Td 59.41358 Tz (and ) Tj 1.205556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 59.143519 Tz (combined ) Tj 2.975 0 Td 54.012346 Tz (box-counting ) Tj 51.428571 0 0 51.428571 0 295.29601 Tm 25.297222 0 Td 58.333333 Tz (and ) Tj 1.322222 0 Td 86.419753 Tz (mBm ) Tj 1.827778 0 Td 60.493827 Tz (method ) Tj 2.411111 0 Td 61.574074 Tz (was ) Tj 1.341667 0 Td 63.734568 Tz (5%, ) Tj 1.4 0 Td 58.333333 Tz (which ) Tj 2.022222 0 Td 60.493827 Tz (was ) Tj 1.361111 0 Td 49.691358 Tz (not ) Tj 1.166667 0 Td 41.880342 Tz (statistically ) Tj 3.538889 0 Td 59.41358 Tz (sig ) Tj 51.428571 0 0 51.428571 0 256.037394 Tm 25.297222 0 Td 45.775463 Tz (nificant ) Tj 2.411111 0 Td 50.87963 Tz (\(p=0.058\). ) Tj 3.305556 0 Td 56.17284 Tz (\(Comparisons ) Tj 4.297222 0 Td 58.333333 Tz (were ) Tj 1.594444 0 Td 56.532922 Tz (performed ) Tj 3.286111 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 60.925926 Tz (accor ) Tj 51.428571 0 0 51.428571 0 214.368098 Tm 25.297222 0 Td 57.037037 Tz (dance ) Tj 1.847222 0 Td 53.472222 Tz (with ) Tj 1.458333 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 49.691358 Tz (protocols ) Tj 2.858333 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 45.37037 Tz (E. ) Tj 0.777778 0 Td 50.231481 Tz (R. ) Tj 0.797222 0 Td 65.895062 Tz (DeLong ) Tj 2.527778 0 Td 45.37037 Tz (et ) Tj 0.661111 0 Td 37.268519 Tz (al., ) Tj 1.069444 0 Td 59.953704 Tz 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Tj 1.847222 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 54.012346 Tz (one-dimensional ) Tj 5.036111 0 Td 50.231481 Tz (data ) Tj 1.4 0 Td 38.888889 Tz (is ) Tj 0.641667 0 Td 52.572016 Tz (converted ) Tj 3.033333 0 Td 45.37037 Tz (into ) Tj 1.263889 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 1169.179245 Tm 6.358333 0 Td 56.712963 Tz (pseudo ) Tj 2.177778 0 Td 54.228395 Tz (two-dimensional ) Tj 5.016667 0 Td 54.012346 Tz (format ) Tj 2.041667 0 Td 59.953704 Tz (by ) Tj 0.855556 0 Td 47.395833 Tz (plotting ) Tj 2.372222 0 Td 55.092593 Tz (each ) Tj 1.477778 0 Td 49.421296 Tz (data ) Tj 1.302778 0 Td 50.555556 Tz (point ) Tj 1.613889 0 Td 50.231481 Tz (as ) Tj 51.428571 0 0 51.428571 0 1127.301266 Tm 6.338889 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 51.851852 Tz (y-value ) Tj 2.411111 0 Td 53.472222 Tz (with ) Tj 1.536111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 53.347578 Tz (corresponding ) Tj 4.394444 0 Td 53.796296 Tz (index ) Tj 1.827778 0 Td 51.851852 Tz (as ) Tj 0.855556 0 Td 50.771605 Tz (the ) Tj 1.147222 0 Td 51.851852 Tz (X-value ) Tj 2.411111 0 Td 50.231481 Tz (as ) Tj 40 0 0 40 0 1091 Tm 8.175 0 Td 66.666667 Tz (discussed ) Tj 3.825 0 Td 60.119048 Tz (herein. ) Tj 51.428571 0 0 51.428571 0 1043.41989 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.894444 0 Td 48.611111 Tz (step ) Tj 1.536111 0 Td 55.092593 Tz (S910, ) Tj 1.963889 0 Td 59.41358 Tz (one ) Tj 1.380556 0 Td 53.472222 Tz (or ) Tj 0.952778 0 Td 62.384259 Tz (more ) Tj 1.827778 0 Td 50.106838 Tz (feature-based ) Tj 4.238889 0 Td 51.527778 Tz (techniques ) Tj 3.422222 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1003.565114 Tm 6.358333 0 Td 51.388889 Tz (applied ) Tj 2.255556 0 Td 46.990741 Tz (to ) Tj 0.680556 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 43.75 Tz (in ) Tj 0.641667 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 46.990741 Tz (training ) Tj 2.372222 0 Td 40.509259 Tz (set. ) Tj 1.127778 0 Td 59.143519 Tz (Examples ) Tj 2.994444 0 Td 53.472222 Tz (of ) Tj 0.7 0 Td 46.990741 Tz (suitable ) Tj 2.372222 0 Td 53.703704 Tz (feature ) Tj 51.428571 0 0 51.428571 0 961.076923 Tm 6.338889 0 Td 56.388889 Tz (based ) Tj 2.236111 0 Td 51.527778 Tz (techniques ) Tj 3.655556 0 Td 50.925926 Tz (include ) Tj 2.702778 0 Td 42.939815 Tz (fast ) Tj 1.594444 0 Td 50.462963 Tz (Fourier ) Tj 2.625 0 Td 49.016204 Tz (analysis ) Tj 2.936111 0 Td 57.685185 Tz (\(FFA\) ) Tj 51.428571 0 0 51.428571 0 922.009434 Tm 6.377778 0 Td 51.851852 Tz (\(S910a\), ) Tj 2.683333 0 Td 43.518519 Tz (fractal ) Tj 1.983333 0 Td 49.016204 Tz (analysis ) Tj 2.527778 0 Td 40.509259 Tz (\(e.g., ) Tj 1.594444 0 Td 54.282407 Tz (box-counting ) Tj 4.063889 0 Td 43.981481 Tz (fractal ) Tj 1.983333 0 Td 48.251029 Tz (analysis\) ) Tj 51.428571 0 0 51.428571 0 876.175031 Tm 6.377778 0 Td 51.851852 Tz (\(S910b\), ) Tj 2.761111 0 Td 51.419753 Tz (wavelet-Fourier ) Tj 4.861111 0 Td 48.611111 Tz (analysis ) Tj 2.586111 0 Td 68.703704 Tz (\(WFA\) ) Tj 2.333333 0 Td 50.636574 Tz (\(S910c\), ) Tj 2.702778 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 48.611111 Tz (the ) Tj 51.428571 0 0 51.428571 0 835.347188 Tm 6.358333 0 Td 41.481481 Tz (like. ) Tj 1.516667 0 Td 50.231481 Tz (Fast ) Tj 1.438889 0 Td 50.925926 Tz (Fourier ) Tj 2.352778 0 Td 48.611111 Tz (analysis ) Tj 2.547222 0 Td 60.493827 Tz (and ) Tj 1.302778 0 Td 51.635802 Tz (wavelet-Fourier ) Tj 4.841667 0 Td 48.611111 Tz (analysis ) Tj 2.566667 0 Td 50.771605 Tz (are ) Tj 51.428571 0 0 51.428571 0 793.765983 Tm 6.358333 0 Td 51.851852 Tz (described ) Tj 2.936111 0 Td 45.37037 Tz (in ) Tj 0.680556 0 Td 49.421296 Tz (publications ) Tj 3.733333 0 Td 54.282407 Tz (such ) Tj 1.458333 0 Td 48.611111 Tz (as ) Tj 0.777778 0 Td 46.990741 Tz (E. ) Tj 0.680556 0 Td 56.712963 Tz (A. ) Tj 0.894444 0 Td 55.902778 Tz (Essocket ) Tj 2.819444 0 Td 37.268519 Tz (al., ) Tj 1.011111 0 Td 52.256944 Tz (Fourier ) Tj 51.428571 0 0 51.428571 0 753.312422 Tm 6.358333 0 Td 48.611111 Tz (analysis ) Tj 2.644444 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 52.5 Tz (nerve ) Tj 1.866667 0 Td 45.37037 Tz (fiber ) Tj 1.613889 0 Td 49.259259 Tz (layer ) Tj 1.769444 0 Td 56.983025 Tz (measurements ) Tj 4.413889 0 Td 56.712963 Tz (from ) Tj 1.672222 0 Td 54.282407 Tz (Scanning ) Tj 51.428571 0 0 51.428571 0 714.674091 Tm 6.358333 0 Td 46.666667 Tz (laser ) Tj 1.497222 0 Td 51.557239 Tz (polarimetry ) Tj 3.577778 0 Td 45.37037 Tz (in ) Tj 0.680556 0 Td 55.812757 Tz (glaucoma: ) Tj 3.188889 0 Td 55.976431 Tz (emphasizing ) Tj 3.830556 0 Td 55.092593 Tz (shape ) Tj 1.808333 0 Td 53.292181 Tz (character ) Tj 51.428571 0 0 51.428571 0 670.335868 Tm 6.358333 0 Td 41.049383 Tz (istics ) Tj 1.711111 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 49.691358 Tz (the ) Tj 1.322222 0 Td 59.217172 Tz (double-hump ) Tj 4.297222 0 Td 46.090535 Tz (pattern. ) Tj 2.702778 0 Td 61.574074 Tz (9 ) Tj 0.602778 0 Td 37.268519 Tz (J. ) Tj 0.680556 0 Td 62.384259 Tz (Glaucoma ) Tj 3.247222 0 Td 56.712963 Tz (444-52 ) Tj 51.428571 0 0 51.428571 0 627.571816 Tm 6.377778 0 Td 52.932099 Tz (\(2000\) ) Tj 2.236111 0 Td 58.333333 Tz (and ) Tj 1.4 0 Td 48.611111 Tz (E. ) Tj 0.855556 0 Td 56.712963 Tz (A. ) Tj 1.05 0 Td 58.333333 Tz (Es ) Tj 1.030556 0 Td 55.902778 Tz (sock ) Tj 1.633333 0 Td 45.37037 Tz (et ) Tj 0.836111 0 Td 37.268519 Tz (al., ) Tj 1.186111 0 Td 52.211934 Tz (Analysis ) Tj 3.15 0 Td 56.712963 Tz (of ) Tj 0.913889 0 Td 75 Tz (GDx-VCC ) Tj 51.428571 0 0 51.428571 0 587.284514 Tm 6.377778 0 Td 51.262626 Tz (Polarimetry ) Tj 3.675 0 Td 55.092593 Tz (Data ) Tj 1.516667 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 52.716049 Tz (Wavelet-Fourier ) Tj 4.880556 0 Td 53.06713 Tz (Analysis ) Tj 2.761111 0 Td 50.231481 Tz (across ) Tj 2.002778 0 Td 69.675926 Tz (Glau ) Tj 51.428571 0 0 51.428571 0 544.859951 Tm 6.358333 0 Td 65.625 Tz (coma ) Tj 1.730556 0 Td 48.611111 Tz (Stages. ) Tj 2.488889 0 Td 53.148148 Tz (46\(8\) ) Tj 1.75 0 Td 44.444444 Tz (Invest. ) Tj 2.041667 0 Td 54.79798 Tz (Ophthalmol. ) Tj 3.811111 0 Td 90.740741 Tz (& ) Tj 0.661111 0 Td 46.990741 Tz (Vis. ) Tj 1.322222 0 Td 44.560185 Tz (Sci. ) Tj 1.263889 0 Td 56.944444 Tz (2838-47 ) Tj 51.428571 0 0 51.428571 0 505.465116 Tm 6.377778 0 Td 55.555556 Tz (\(August ) Tj 2.508333 0 Td 51.311728 Tz (2005\). ) Tj 51.428571 0 0 51.428571 0 463.218905 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.719444 0 Td 47.800926 Tz (step ) Tj 1.302778 0 Td 55.740741 Tz (S912, ) Tj 1.788889 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 47.800926 Tz (features ) Tj 2.430556 0 Td 48.611111 Tz (for ) Tj 0.972222 0 Td 50.968013 Tz (progressors ) Tj 3.480556 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 56.565657 Tz (non-progres ) Tj 51.428571 0 0 51.428571 0 422.034356 Tm 6.377778 0 Td 47.800926 Tz (sors ) Tj 1.361111 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 55.092593 Tz (each ) Tj 1.555556 0 Td 59.548611 Tz (combined ) Tj 3.033333 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 56.018519 Tz (produce ) Tj 2.547222 0 Td 51.851852 Tz (progressor ) Tj 3.266667 0 Td 59.41358 Tz (and ) Tj 1.283333 0 Td 60.185185 Tz (non-pro ) Tj 51.428571 0 0 51.428571 0 377.171771 Tm 6.358333 0 Td 50.925926 Tz (gressor ) Tj 2.430556 0 Td 50.231481 Tz (data ) Tj 1.497222 0 Td 42.12963 Tz (sets. ) Tj 1.633333 0 Td 45.37037 Tz (In ) Tj 0.875 0 Td 64.00463 Tz (some ) Tj 1.847222 0 Td 56.983025 Tz (embodiments, ) Tj 4.413889 0 Td 55.092593 Tz (each ) Tj 1.633333 0 Td 51.041667 Tz (data ) Tj 1.555556 0 Td 43.209877 Tz (set ) Tj 1.088889 0 Td 40.509259 Tz (is ) Tj 40 0 0 40 0 343 Tm 8.175 0 Td 66.666667 Tz (normalized. ) Tj 51.428571 0 0 51.428571 0 295.565841 Tm 7.116667 0 Td 46.990741 Tz (In ) Tj 0.797222 0 Td 47.800926 Tz (step ) Tj 1.361111 0 Td 55.740741 Tz (S914, ) Tj 1.866667 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 48.148148 Tz (feature ) Tj 2.236111 0 Td 49.074074 Tz (vectors ) Tj 2.255556 0 Td 50.771605 Tz (are ) Tj 1.108333 0 Td 47.222222 Tz (further ) Tj 2.158333 0 Td 53.652263 Tz (processed ) Tj 3.091667 0 Td 61.574074 Tz (by ) Tj 51.428571 0 0 51.428571 0 255.934132 Tm 6.338889 0 Td 53.148148 Tz (using ) Tj 1.75 0 Td 48.251029 Tz (principal ) Tj 2.8 0 Td 58.009259 Tz (components ) Tj 3.675 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 63.518519 Tz (\(PCA\) ) Tj 2.061111 0 Td 46.990741 Tz (to ) Tj 0.777778 0 Td 59.548611 Tz (maximize ) Tj 3.033333 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 211.896595 Tm 6.377778 0 Td 52.391975 Tz (spread ) Tj 2.158333 0 Td 55.092593 Tz (of ) Tj 0.836111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 50.231481 Tz (data ) Tj 1.458333 0 Td 49.151235 Tz (points ) Tj 2.061111 0 Td 43.75 Tz (in ) Tj 0.797222 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.8107 Tz (resultant ) Tj 2.8 0 Td 52.662037 Tz (multidimensional ) Tj 51.428571 0 0 51.428571 0 170.160237 Tm 6.377778 0 Td 51.49177 Tz (\(reduced\) ) Tj 2.975 0 Td 47.685185 Tz (feature ) Tj 2.177778 0 Td 49.151235 Tz (space. ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1716 Tm 41.6 0 Td 80.555556 Tz (30 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 51.428571 0 0 51.428571 0 2969 Tm 33.6 0 Td 74.537037 Tz (14 ) Tj 51.428571 0 0 51.428571 0 2913.605128 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.758333 0 Td 47.800926 Tz (step ) Tj 1.341667 0 Td 55.092593 Tz (S916, ) Tj 1.808333 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 45.37037 Tz (linear ) Tj 1.808333 0 Td 50.771605 Tz (discriminant ) Tj 3.791667 0 Td 49.421296 Tz (function ) Tj 2.566667 0 Td 61.574074 Tz (\(LDF\) ) Tj 2.022222 0 Td 55.092593 Tz (such ) Tj 1.477778 0 Td 51.851852 Tz (as ) Tj 51.428571 0 0 51.428571 0 2871.249032 Tm 25.316667 0 Td 48.206019 Tz (Fisher's ) Tj 2.644444 0 Td 45.910494 Tz (linear ) Tj 1.925 0 Td 50.771605 Tz (discriminant ) Tj 3.947222 0 Td 49.826389 Tz (function ) Tj 2.702778 0 Td 38.888889 Tz (is ) Tj 0.777778 0 Td 55.902778 Tz (used ) Tj 1.613889 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 56.018519 Tz (produce ) Tj 2.644444 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2829.617391 Tm 25.297222 0 Td 45.138889 Tz (classification ) Tj 4.083333 0 Td 51.851852 Tz (algorithm ) Tj 3.130556 0 Td 59.953704 Tz (of ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.205556 0 Td 54.166667 Tz (reduced ) Tj 2.586111 0 Td 50.925926 Tz (dimensionality ) Tj 4.608333 0 Td 76.157407 Tz (FD ) Tj 40 0 0 40 0 2790 Tm 32.525 0 Td 58.333333 Tz (data. ) Tj 51.428571 0 0 51.428571 0 2739.607595 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.719444 0 Td 48.611111 Tz (step ) Tj 1.302778 0 Td 55.092593 Tz (S918, ) Tj 1.808333 0 Td 48.611111 Tz (the ) Tj 0.991667 0 Td 50.555556 Tz (best ) Tj 1.944444 0 Td 47.530864 Tz (linear ) Tj 1.808333 0 Td 50.501543 Tz (discriminant ) Tj 3.772222 0 Td 49.826389 Tz (function ) Tj 2.547222 0 Td 60.925926 Tz (\(LDF\) ) Tj 51.428571 0 0 51.428571 0 2697.239234 Tm 25.297222 0 Td 38.888889 Tz (is ) Tj 0.622222 0 Td 54.12037 Tz (determined ) Tj 3.363889 0 Td 53.703704 Tz (through ) Tj 2.411111 0 Td 52.932099 Tz (use ) Tj 1.069444 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 49.691358 Tz (the ) Tj 0.991667 0 Td 47.800926 Tz (training ) Tj 2.391667 0 Td 39.699074 Tz (set. ) Tj 1.127778 0 Td 48.611111 Tz (In ) Tj 0.680556 0 Td 64.814815 Tz (some ) Tj 1.672222 0 Td 66.975309 Tz (embodi ) Tj 48.571429 0 0 48.571429 0 2653 Tm 26.826471 0 Td 54.901961 Tz (ments, ) Tj 2.202941 0 Td 51.470588 Tz (the ) Tj 1.111765 0 Td 53.529412 Tz (best ) Tj 2.161765 0 Td 78.921569 Tz (LDF ) Tj 1.585294 0 Td 59.477124 Tz (can ) Tj 1.255882 0 Td 63.480392 Tz (be ) Tj 0.947059 0 Td 52.614379 Tz (the ) Tj 1.111765 0 Td 46.323529 Tz (classifier ) Tj 2.944118 0 Td 48.897059 Tz (that ) Tj 1.338235 0 Td 56.188725 Tz (accounts ) Tj 2.902941 0 Td 51.470588 Tz (for ) Tj 40 0 0 40 0 2616 Tm 32.5 0 Td 65.277778 Tz (the ) Tj 1.45 0 Td 88.690476 Tz (maximum ) Tj 3.975 0 Td 78.472222 Tz (amount ) Tj 3.075 0 Td 72.916667 Tz (of ) Tj 1.025 0 Td 61.111111 Tz (variance. ) Tj 38.571429 0 0 38.571429 0 2535 Tm 39.018519 0 Td 99.382716 Tz (THIRD ) Tj 3.214815 0 Td 109.876543 Tz (WORKING ) Tj 4.951852 0 Td 108.024691 Tz (EXAMPLE ) Tj 51.428571 0 0 51.428571 0 2441.512635 Tm 28.369444 0 Td 49.259259 Tz (Prediction ) Tj 3.130556 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 51.262626 Tz (Progression ) Tj 3.558333 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 62.789352 Tz (Glaucoma ) Tj 51.428571 0 0 51.428571 0 2359.16129 Tm 26.016667 0 Td 72.916667 Tz (An ) Tj 1.186111 0 Td 55.092593 Tz (experiment ) Tj 3.616667 0 Td 61.574074 Tz (was ) Tj 1.438889 0 Td 55.452675 Tz (conducted ) Tj 3.325 0 Td 53.472222 Tz (with ) Tj 1.594444 0 Td 59.953704 Tz (96 ) Tj 1.05 0 Td 44.650206 Tz (patients, ) Tj 2.761111 0 Td 58.981481 Tz (which ) Tj 51.428571 0 0 51.428571 0 2316.525773 Tm 25.277778 0 Td 59.953704 Tz (were ) Tj 1.691667 0 Td 53.472222 Tz (followed ) Tj 2.819444 0 Td 45.37037 Tz (starting ) Tj 2.430556 0 Td 56.712963 Tz (from ) Tj 1.691667 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 49.826389 Tz (baseline ) Tj 2.663889 0 Td 58.333333 Tz (up ) Tj 0.972222 0 Td 45.37037 Tz (to ) Tj 0.797222 0 Td 63.194444 Tz (40 ) Tj 1.011111 0 Td 54.166667 Tz (months. ) Tj 51.428571 0 0 51.428571 0 2274.915058 Tm 25.316667 0 Td 76.967593 Tz (RNFL ) Tj 2.119444 0 Td 49.691358 Tz (thickness ) Tj 3.013889 0 Td 60.493827 Tz (was ) Tj 1.419444 0 Td 57.523148 Tz (measured ) Tj 3.052778 0 Td 48.611111 Tz (for ) Tj 1.108333 0 Td 55.902778 Tz (each ) Tj 1.652778 0 Td 49.074074 Tz (subject ) Tj 2.352778 0 Td 51.851852 Tz (using ) Tj 1.827778 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2233.965174 Tm 25.297222 0 Td 75.752315 Tz (GDxVCCTM ) Tj 3.927778 0 Td 52.391975 Tz (device ) Tj 2.197222 0 Td 53.846154 Tz (approximately ) Tj 4.511111 0 Td 53.148148 Tz (every ) Tj 1.905556 0 Td 47.530864 Tz (six ) Tj 1.166667 0 Td 55.092593 Tz (months. ) Tj 2.605556 0 Td 63.734568 Tz (The ) Tj 51.428571 0 0 51.428571 0 2195.88207 Tm 25.316667 0 Td 48.206019 Tz (Subjects ) Tj 2.566667 0 Td 59.143519 Tz (were ) Tj 1.691667 0 Td 62.114198 Tz (deemed ) Tj 2.488889 0 Td 49.074074 Tz (progressors. ) Tj 4.394444 0 Td 50.411523 Tz (non-progressors. ) Tj 5.716667 0 Td 51.851852 Tz (or ) Tj 51.428571 0 0 51.428571 0 2149.666116 Tm 25.297222 0 Td 51.851852 Tz (ocular ) Tj 2.313889 0 Td 51.041667 Tz (healthy ) Tj 2.644444 0 Td 59.953704 Tz (on ) Tj 0.933333 0 Td 48.611111 Tz (the ) Tj 1.030556 0 Td 48.611111 Tz (basis ) Tj 1.652778 0 Td 56.712963 Tz (of ) Tj 0.836111 0 Td 46.990741 Tz (visual ) Tj 1.905556 0 Td 40.740741 Tz (fields. ) Tj 51.428571 0 0 51.428571 0 2108.738693 Tm 25.297222 0 Td 59.143519 Tz (Case ) Tj 1.730556 0 Td 38.888889 Tz (1- ) Tj 1.030556 0 Td 46.990741 Tz (Classification ) Tj 4.258333 0 Td 59.259259 Tz (Between ) Tj 2.761111 0 Td 50.968013 Tz (Progressors ) Tj 3.616667 0 Td 59.41358 Tz (and ) Tj 1.341667 0 Td 64.814815 Tz (Non-Pro ) Tj 51.428571 0 0 51.428571 0 2069.057554 Tm 25.297222 0 Td 51.388889 Tz (gressor ) Tj 2.294444 0 Td 46.990741 Tz (Patients ) Tj 2.469444 0 Td 50.05144 Tz (\(Training ) Tj 2.897222 0 Td 52.662037 Tz (with ) Tj 1.458333 0 Td 63.518519 Tz (Mixed ) Tj 2.080556 0 Td 50.968013 Tz (Progressors ) Tj 3.538889 0 Td 59.41358 Tz (and ) Tj 1.225 0 Td 83.179012 Tz (Non ) Tj 51.428571 0 0 51.428571 0 2026.876056 Tm 25.297222 0 Td 50.673401 Tz (progressors ) Tj 3.558333 0 Td 47.685185 Tz (Patient ) Tj 2.216667 0 Td 51.851852 Tz (Data\) ) Tj 51.428571 0 0 51.428571 0 1985.034839 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 55.902778 Tz (complete ) Tj 2.955556 0 Td 47.685185 Tz (dataset ) Tj 2.255556 0 Td 56.17284 Tz (comprised ) Tj 3.286111 0 Td 59.953704 Tz (of ) Tj 0.836111 0 Td 50.231481 Tz (baseline ) Tj 2.702778 0 Td 76.157407 Tz (RNFL ) Tj 2.080556 0 Td 69.135802 Tz (SLP ) Tj 51.428571 0 0 51.428571 0 1944.219668 Tm 25.297222 0 Td 51.041667 Tz (data ) Tj 1.497222 0 Td 46.990741 Tz (that ) Tj 1.458333 0 Td 49.826389 Tz (includes ) Tj 2.761111 0 Td 56.712963 Tz (14 ) Tj 0.972222 0 Td 50.968013 Tz (progressors ) Tj 3.675 0 Td 58.333333 Tz (and ) Tj 1.361111 0 Td 59.953704 Tz (45 ) Tj 1.069444 0 Td 51.851852 Tz (non-progressors ) Tj 51.428571 0 0 51.428571 0 1901.956522 Tm 25.297222 0 Td 46.990741 Tz (patients ) Tj 2.527778 0 Td 60.493827 Tz (was ) Tj 1.361111 0 Td 43.209877 Tz (utilized. ) Tj 2.625 0 Td 57.685185 Tz (Using ) Tj 1.963889 0 Td 73.45679 Tz (90% ) Tj 1.575 0 Td 61.574074 Tz (of ) Tj 0.894444 0 Td 42.939815 Tz (this ) Tj 1.302778 0 Td 45.37037 Tz (dataset, ) Tj 2.430556 0 Td 49.691358 Tz (the ) Tj 1.166667 0 Td 45.37037 Tz (target ) Tj 51.428571 0 0 51.428571 0 1858.141498 Tm 25.297222 0 Td 43.425926 Tz (classifier ) Tj 2.741667 0 Td 47.530864 Tz (for ) Tj 0.952778 0 Td 55.092593 Tz (each ) Tj 1.477778 0 Td 50.106838 Tz (feature-based ) Tj 4.044444 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 36.188272 Tz (\(i.e., ) Tj 1.477778 0 Td 59.143519 Tz (FFA, ) Tj 1.555556 0 Td 85.339506 Tz (WFA ) Tj 1.672222 0 Td 59.41358 Tz (and ) Tj 51.428571 0 0 51.428571 0 1819.548947 Tm 25.316667 0 Td 61.574074 Tz (FA\) ) Tj 1.341667 0 Td 60.493827 Tz (was ) Tj 1.361111 0 Td 49.331276 Tz (obtained. ) Tj 2.897222 0 Td 54.282407 Tz (This ) Tj 1.575 0 Td 54.012346 Tz (procedure ) Tj 3.169444 0 Td 55.740741 Tz (found ) Tj 1.925 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 48.148148 Tz (representative ) Tj 51.428571 0 0 51.428571 0 1776.348449 Tm 25.297222 0 Td 47.800926 Tz (features ) Tj 2.411111 0 Td 59.41358 Tz (and ) Tj 1.166667 0 Td 59.953704 Tz (by ) Tj 0.875 0 Td 51.851852 Tz (using ) Tj 1.691667 0 Td 68.055556 Tz (LDA, ) Tj 1.75 0 Td 50.771605 Tz (the ) Tj 1.05 0 Td 46.450617 Tz (resulting ) Tj 2.663889 0 Td 74.537037 Tz (LDF ) Tj 1.458333 0 Td 43.013468 Tz (classifiers ) Tj 2.994444 0 Td 59.143519 Tz (were ) Tj 40 0 0 40 0 1740 Tm 32.525 0 Td 63.425926 Tz (obtained. ) Tj 51.428571 0 0 51.428571 0 1692.83727 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.438889 0 Td 43.308081 Tz (classifiers ) Tj 3.188889 0 Td 44.560185 Tz (that ) Tj 1.341667 0 Td 50.231481 Tz (best ) Tj 1.458333 0 Td 49.151235 Tz (characterize ) Tj 3.85 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 51.557239 Tz (progression ) Tj 3.694444 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 1651.393325 Tm 25.297222 0 Td 50 Tz (disease ) Tj 2.236111 0 Td 59.143519 Tz (were ) Tj 1.575 0 Td 48.611111 Tz (selected ) Tj 2.469444 0 Td 46.018519 Tz (next. ) Tj 1.516667 0 Td 64.814815 Tz (The ) Tj 1.283333 0 Td 46.296296 Tz (testing ) Tj 2.080556 0 Td 51.041667 Tz (data ) Tj 1.341667 0 Td 62.654321 Tz (was ) Tj 1.283333 0 Td 61.168981 Tz (composed ) Tj 3.091667 0 Td 56.712963 Tz (of ) Tj 51.428571 0 0 51.428571 0 1610.809988 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 54.372428 Tz (remaining ) Tj 3.188889 0 Td 68.055556 Tz (10% ) Tj 1.419444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.088889 0 Td 44.965278 Tz (dataset. ) Tj 2.430556 0 Td 51.203704 Tz (Here, ) Tj 1.691667 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 51.851852 Tz (non-progressors ) Tj 51.428571 0 0 51.428571 0 1569.444444 Tm 25.277778 0 Td 59.953704 Tz (were ) Tj 1.555556 0 Td 51.446759 Tz (replaced ) Tj 2.586111 0 Td 52.662037 Tz (with ) Tj 1.4 0 Td 50.771605 Tz (the ) Tj 0.991667 0 Td 53.703704 Tz (average ) Tj 2.411111 0 Td 49.691358 Tz (values ) Tj 1.944444 0 Td 53.472222 Tz (of ) Tj 0.719444 0 Td 52.546296 Tz (non-progressor ) Tj 4.511111 0 Td 43.75 Tz (at ) Tj 0.622222 0 Td 41.049383 Tz (all ) Tj 51.428571 0 0 51.428571 0 1529.795918 Tm 25.297222 0 Td 42.12963 Tz (visits ) Tj 1.691667 0 Td 48.611111 Tz (to ) Tj 0.777778 0 Td 51.388889 Tz (prevent ) Tj 2.352778 0 Td 43.126781 Tz (over-fitting. ) Tj 51.428571 0 0 51.428571 0 1484.050761 Tm 26.016667 0 Td 63.734568 Tz (The ) Tj 1.283333 0 Td 48.611111 Tz (best ) Tj 1.361111 0 Td 67.24537 Tz (LDFs ) Tj 1.769444 0 Td 52.662037 Tz (obtained ) Tj 2.683333 0 Td 58.333333 Tz (from ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 46.990741 Tz (training ) Tj 2.391667 0 Td 55.740741 Tz (phase ) Tj 1.847222 0 Td 58.333333 Tz (were ) Tj 1.575 0 Td 51.041667 Tz (next ) Tj 51.428571 0 0 51.428571 0 1443.245098 Tm 25.297222 0 Td 50.925926 Tz (applied ) Tj 2.333333 0 Td 59.953704 Tz (on ) Tj 0.913889 0 Td 49.691358 Tz (the ) Tj 1.088889 0 Td 46.296296 Tz (testing ) Tj 2.119444 0 Td 46.018519 Tz (data. ) Tj 1.613889 0 Td 59.143519 Tz (Each ) Tj 1.633333 0 Td 50.106838 Tz (feature-based ) Tj 4.083333 0 Td 49.016204 Tz (analysis ) Tj 2.566667 0 Td 61.574074 Tz (was ) Tj 51.428571 0 0 51.428571 0 1402.449275 Tm 25.297222 0 Td 51.446759 Tz (assessed ) Tj 2.566667 0 Td 61.574074 Tz (by ) Tj 0.894444 0 Td 48.316498 Tz (calculating ) Tj 3.266667 0 Td 76.157407 Tz (AUROCs ) Tj 2.858333 0 Td 46.990741 Tz (at ) Tj 0.758333 0 Td 32.407407 Tz (1 ) Tj 0.408333 0 Td 53.472222 Tz (scan ) Tj 1.419444 0 Td 43.209877 Tz (prior, ) Tj 1.691667 0 Td 58.333333 Tz (2 ) Tj 0.486111 0 Td 51.851852 Tz (scans ) Tj 1.691667 0 Td 48.611111 Tz (prior ) Tj 51.428571 0 0 51.428571 0 1359.622279 Tm 25.297222 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 58.333333 Tz (3 ) Tj 0.661111 0 Td 51.203704 Tz (scans ) Tj 1.808333 0 Td 47.962963 Tz (prior ) Tj 1.652778 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 50.771605 Tz (the ) Tj 1.166667 0 Td 49.151235 Tz (progression. ) Tj 3.791667 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 45.775463 Tz (interval ) Tj 2.45 0 Td 58.333333 Tz (between ) Tj 51.428571 0 0 51.428571 0 1320.732121 Tm 25.316667 0 Td 50.231481 Tz (Successive ) Tj 3.227778 0 Td 51.203704 Tz (scans ) Tj 1.75 0 Td 46.450617 Tz (\(prior ) Tj 1.808333 0 Td 48.611111 Tz (to ) Tj 0.758333 0 Td 50.501543 Tz (progression\) ) Tj 3.85 0 Td 61.574074 Tz (was ) Tj 1.302778 0 Td 53.596866 Tz (approximately ) Tj 4.413889 0 Td 51.851852 Tz (6 ) Tj 40 0 0 40 0 1282 Tm 32.525 0 Td 70.238095 Tz (months. ) Tj 51.428571 0 0 51.428571 0 1236.323246 Tm 26.036111 0 Td 55.092593 Tz (FIG. ) Tj 1.652778 0 Td 58.333333 Tz (10 ) Tj 0.972222 0 Td 52.662037 Tz (provides ) Tj 2.8 0 Td 51.851852 Tz (a ) Tj 0.622222 0 Td 55.740741 Tz (comparison ) Tj 3.675 0 Td 59.953704 Tz (of ) Tj 0.952778 0 Td 77.777778 Tz (ROC ) Tj 1.691667 0 Td 52.391975 Tz (curves ) Tj 2.197222 0 Td 48.611111 Tz (for ) Tj 1.127778 0 Td 43.75 Tz (fast ) Tj 51.428571 0 0 51.428571 0 1193.240373 Tm 25.316667 0 Td 50.925926 Tz (Fourier ) Tj 2.255556 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 53.472222 Tz (\(FFA\), ) Tj 2.080556 0 Td 51.419753 Tz (wavelet-Fourier ) Tj 4.725 0 Td 48.611111 Tz (analysis ) Tj 2.488889 0 Td 61.574074 Tz (\(WFA\), ) Tj 2.333333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1151.878825 Tm 25.297222 0 Td 43.981481 Tz (fractal ) Tj 2.041667 0 Td 49.016204 Tz (analysis ) Tj 2.566667 0 Td 48.611111 Tz (for ) Tj 1.030556 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 44.907407 Tz (classification ) Tj 3.986111 0 Td 56.712963 Tz (of ) Tj 0.797222 0 Td 50.968013 Tz (progressors ) Tj 3.597222 0 Td 43.209877 Tz (vs. ) Tj 1.030556 0 Td 72.376543 Tz (non ) Tj 38.571429 0 0 38.571429 0 1114 Tm 33.703704 0 Td 65.174897 Tz (progressors. ) Tj 51.428571 0 0 51.428571 0 1067.289673 Tm 26.016667 0 Td 53.796296 Tz (Table ) Tj 1.730556 0 Td 58.333333 Tz (3 ) Tj 0.525 0 Td 58.333333 Tz (below ) Tj 1.905556 0 Td 51.851852 Tz (provides ) Tj 2.663889 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 81.018519 Tz (AUROC ) Tj 2.586111 0 Td 50.771605 Tz (values ) Tj 1.983333 0 Td 48.611111 Tz (for ) Tj 1.011111 0 Td 43.75 Tz (fast ) Tj 1.205556 0 Td 50.925926 Tz (Fourier ) Tj 51.428571 0 0 51.428571 0 1027.28436 Tm 25.297222 0 Td 48.611111 Tz (analysis ) Tj 2.547222 0 Td 53.472222 Tz (\(FFA\), ) Tj 2.119444 0 Td 51.419753 Tz (wavelet-Fourier ) Tj 4.744444 0 Td 49.016204 Tz (analysis ) Tj 2.566667 0 Td 61.574074 Tz (\(WFA\), ) Tj 2.372222 0 Td 61.574074 Tz (and ) Tj 1.263889 0 Td 43.981481 Tz (fractal ) Tj 51.428571 0 0 51.428571 0 988.54386 Tm 25.297222 0 Td 48.611111 Tz (analysis ) Tj 2.508333 0 Td 61.574074 Tz (by ) Tj 0.972222 0 Td 37.808642 Tz (visit. ) Tj 38.571429 0 0 38.571429 0 904 Tm 43.477778 0 Td 101.975309 Tz (TABLE ) Tj 3.266667 0 Td 77.777778 Tz (3 ) Tj 31.428571 0 0 31.428571 0 837 Tm 43.113636 0 Td 106.060606 Tz (AUROC ) Tj 3.372727 0 Td 68.055556 Tz (Values ) Tj 2.704545 0 Td 61.868687 Tz (for ) Tj 1.368182 0 Td 88.383838 Tz (FFA ) Tj 1.972727 0 Td 90.151515 Tz (WFA, ) Tj 2.513636 0 Td 70.707071 Tz (and ) Tj 1.590909 0 Td 87.5 Tz (FA ) Tj 1.304545 0 Td 76.515152 Tz (Methods ) Tj 3.5 0 Td 68.939394 Tz (on ) Tj 1.145455 0 Td 62.575758 Tz (DifferentVisits ) Tj 30 0 0 30 0 771 Tm 51.933333 0 Td 108.888889 Tz (AUROC ) Tj 7.766667 0 Td 107.777778 Tz (AUROC ) Tj 7.766667 0 Td 107.777778 Tz (AUROC ) Tj 39.142857 0 0 39.142857 0 733.046512 Tm 34.718978 0 Td 63.868613 Tz (Method ) Tj 4.266423 0 Td 42.579075 Tz (\(1 ) Tj 0.766423 0 Td 59.610706 Tz (Scan ) Tj 1.686131 0 Td 46.127332 Tz (Prior\) ) Tj 3.5 0 Td 46.836983 Tz (\(2 ) Tj 0.766423 0 Td 59.610706 Tz (Scan ) Tj 1.686131 0 Td 46.127332 Tz (Prior\) ) Tj 3.5 0 Td 44.708029 Tz (\(3 ) Tj 0.766423 0 Td 59.610706 Tz (Scan ) Tj 1.686131 0 Td 46.127332 Tz (Prior\) ) Tj 30 0 0 30 0 676 Tm 45.366667 0 Td 90.740741 Tz (FFA ) Tj 7.333333 0 Td 69.444444 Tz (O.82 ) Tj 7.766667 0 Td 66.666667 Tz (O.71 ) Tj 7.766667 0 Td 68.055556 Tz (O.63 ) Tj 30 0 0 30 0 643 Tm 45.266667 0 Td 120.37037 Tz (WFA ) Tj 7.433333 0 Td 69.444444 Tz (O.78 ) Tj 7.766667 0 Td 69.444444 Tz (O.78 ) Tj 7.766667 0 Td 69.444444 Tz (0.67 ) Tj 30 0 0 30 0 610 Tm 45.366667 0 Td 91.666667 Tz (FA ) Tj 7.333333 0 Td 69.444444 Tz (O.82 ) Tj 7.766667 0 Td 69.444444 Tz (O.70 ) Tj 7.766667 0 Td 68.055556 Tz (0.73 ) Tj 51.428571 0 0 51.428571 0 503.689571 Tm 25.297222 0 Td 59.143519 Tz (Case ) Tj 1.633333 0 Td 37.268519 Tz (1- ) Tj 1.011111 0 Td 51.851852 Tz (Evaluation ) Tj 3.266667 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 46.548822 Tz (Specificity ) Tj 3.227778 0 Td 45.37037 Tz (in ) Tj 0.680556 0 Td 56.17284 Tz (Ocular ) Tj 2.158333 0 Td 53.703704 Tz (Healthy ) Tj 2.430556 0 Td 47.395833 Tz (Patients ) Tj 51.428571 0 0 51.428571 0 460.245638 Tm 26.036111 0 Td 48.611111 Tz (In ) Tj 0.816667 0 Td 42.939815 Tz (this ) Tj 1.283333 0 Td 46.666667 Tz (case, ) Tj 1.633333 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 46.990741 Tz (training ) Tj 2.469444 0 Td 51.041667 Tz (data ) Tj 1.438889 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 43.013468 Tz (classifiers ) Tj 3.091667 0 Td 46.990741 Tz (\(the ) Tj 1.322222 0 Td 49.421296 Tz (best ) Tj 51.428571 0 0 51.428571 0 419.671498 Tm 25.316667 0 Td 62.87037 Tz (LDFs\) ) Tj 2.002778 0 Td 55.632716 Tz (remain ) Tj 2.119444 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 62.384259 Tz (same ) Tj 1.594444 0 Td 51.851852 Tz (as ) Tj 0.758333 0 Td 51.49177 Tz (discussed ) Tj 2.897222 0 Td 46.990741 Tz (in ) Tj 0.7 0 Td 59.143519 Tz (Case ) Tj 1.613889 0 Td 32.407407 Tz (1 ) Tj 0.427778 0 Td 47.530864 Tz (for ) Tj 0.933333 0 Td 50.968013 Tz 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0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 43.518519 Tz (retinal ) Tj 2.002778 0 Td 53.292181 Tz (pathology ) Tj 3.033333 0 Td 52.932099 Tz (and/or ) Tj 2.022222 0 Td 48.148148 Tz (predict ) Tj 2.138889 0 Td 51.851852 Tz (the ) Tj 1.05 0 Td 52.146465 Tz (progression ) Tj 51.428571 0 0 51.428571 0 1296.003717 Tm 6.358333 0 Td 58.333333 Tz (of ) Tj 0.816667 0 Td 55.092593 Tz (a ) Tj 0.544444 0 Td 43.518519 Tz (retinal ) Tj 2.022222 0 Td 51.203704 Tz (pathology. ) Tj 3.266667 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 44.907407 Tz (classification ) Tj 3.966667 0 Td 52.211934 Tz (algorithm ) Tj 3.072222 0 Td 54.012346 Tz (can ) Tj 1.186111 0 Td 59.953704 Tz (be ) Tj 0.913889 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 1250.540505 Tm 6.358333 0 Td 45.138889 Tz (classification ) Tj 4.258333 0 Td 52.211934 Tz (algorithm ) Tj 3.286111 0 Td 49.074074 Tz (trained ) Tj 2.527778 0 Td 43.75 Tz (in ) Tj 1.011111 0 Td 54.768519 Tz (accordance ) Tj 3.752778 0 Td 52.662037 Tz (with ) Tj 1.75 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 1210.955224 Tm 6.358333 0 Td 48.905724 Tz (description ) Tj 3.402778 0 Td 47.222222 Tz (herein. ) Tj 38.571429 0 0 38.571429 0 1132 Tm 12.548148 0 Td 99.382716 Tz (INCORPORATION ) Tj 8.088889 0 Td 108.024691 Tz (BY ) Tj 1.555556 0 Td 102.263374 Tz (REFERENCE ) Tj 51.428571 0 0 51.428571 0 1042.409714 Tm 7.097222 0 Td 49.691358 Tz (All ) Tj 1.088889 0 Td 46.585648 Tz (patents, ) Tj 2.391667 0 Td 52.572016 Tz (published ) Tj 2.975 0 Td 49.691358 Tz (patent ) Tj 1.944444 0 Td 47.364672 Tz (applications, ) Tj 3.85 0 Td 59.41358 Tz (and ) Tj 1.244444 0 Td 49.907407 Tz (other ) Tj 1.633333 0 Td 53.148148 Tz (refer ) Tj 51.428571 0 0 51.428571 0 1000.517986 Tm 6.358333 0 Td 53.796296 Tz (ences ) Tj 1.808333 0 Td 50.05144 Tz (disclosed ) Tj 2.877778 0 Td 50.771605 Tz (herein ) Tj 2.002778 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 55.092593 Tz (hereby ) Tj 2.177778 0 Td 50.771605 Tz (expressly ) Tj 2.955556 0 Td 51.041667 Tz (incorporated ) Tj 3.830556 0 Td 63.194444 Tz (by ) Tj 51.428571 0 0 51.428571 0 954.532374 Tm 6.358333 0 Td 50.411523 Tz (reference ) Tj 2.916667 0 Td 43.75 Tz (in ) Tj 0.738889 0 Td 44.722222 Tz (their ) Tj 1.497222 0 Td 44.398148 Tz (entireties ) Tj 2.838889 0 Td 59.953704 Tz (by ) Tj 0.933333 0 Td 47.314815 Tz (reference. ) Tj 50 0 0 50 0 875 Tm 12.98 0 Td 76.969697 Tz (EQUIVALENTS ) Tj 51.428571 0 0 51.428571 0 792.761379 Tm 7.097222 0 Td 62.654321 Tz (The ) Tj 1.497222 0 Td 50.411523 Tz (functions ) Tj 3.072222 0 Td 59.953704 Tz (of ) Tj 1.030556 0 Td 47.685185 Tz (several ) Tj 2.391667 0 Td 53.877315 Tz (elements ) Tj 3.013889 0 Td 55.902778 Tz (may, ) Tj 1.730556 0 Td 45.37037 Tz (in ) Tj 0.952778 0 Td 46.254209 Tz (alternative ) Tj 51.428571 0 0 51.428571 0 751.27205 Tm 6.358333 0 Td 56.983025 Tz (embodiments, ) Tj 4.316667 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 48.611111 Tz (carried ) Tj 2.255556 0 Td 51.851852 Tz (out ) Tj 1.108333 0 Td 61.574074 Tz (by ) Tj 0.991667 0 Td 54.444444 Tz (fewer ) Tj 1.827778 0 Td 51.131687 Tz (elements, ) Tj 2.975 0 Td 53.472222 Tz (or ) Tj 0.797222 0 Td 58.333333 Tz (a ) Tj 0.563889 0 Td 48.611111 Tz (single ) Tj 51.428571 0 0 51.428571 0 710.989899 Tm 6.358333 0 Td 51.446759 Tz (element. ) Tj 2.819444 0 Td 46.666667 Tz (Similarly, ) Tj 3.15 0 Td 46.990741 Tz (in ) Tj 0.913889 0 Td 64.00463 Tz (some ) Tj 1.847222 0 Td 56.712963 Tz (embodiments, ) Tj 4.413889 0 Td 57.253086 Tz (any ) Tj 1.4 0 Td 48.611111 Tz (functional ) Tj 51.428571 0 0 51.428571 0 670.460847 Tm 6.358333 0 Td 54.62963 Tz (element ) Tj 2.644444 0 Td 68.055556 Tz (may ) Tj 1.555556 0 Td 55.092593 Tz (perform ) Tj 2.663889 0 Td 48.611111 Tz (fewer, ) Tj 2.1 0 Td 53.472222 Tz (or ) Tj 0.933333 0 Td 44.074074 Tz (different, ) Tj 2.975 0 Td 50.231481 Tz (operations ) Tj 3.363889 0 Td 52.662037 Tz (than ) Tj 51.428571 0 0 51.428571 0 627.035758 Tm 6.338889 0 Td 51.851852 Tz (those ) Tj 1.808333 0 Td 51.49177 Tz (described ) Tj 3.013889 0 Td 52.662037 Tz (with ) Tj 1.536111 0 Td 48.611111 Tz (respect ) Tj 2.275 0 Td 43.75 Tz (to ) Tj 0.777778 0 Td 49.691358 Tz (the ) Tj 1.108333 0 Td 44.191919 Tz (illustrated ) Tj 3.15 0 Td 57.449495 Tz (embodiment. ) Tj 51.428571 0 0 51.428571 0 585.865724 Tm 6.358333 0 Td 51.851852 Tz (Also, ) Tj 1.691667 0 Td 49.259259 Tz (functional ) Tj 3.111111 0 Td 53.472222 Tz (elements ) Tj 2.722222 0 Td 40.509259 Tz (\(e.g., ) Tj 1.633333 0 Td 54.6875 Tz (modules, ) Tj 2.780556 0 Td 49.259259 Tz (databases, ) Tj 3.130556 0 Td 66.435185 Tz (comput ) Tj 51.428571 0 0 51.428571 0 542.637532 Tm 6.358333 0 Td 42.939815 Tz (ers, ) Tj 1.263889 0 Td 43.344907 Tz (clients, ) Tj 2.313889 0 Td 48.611111 Tz (servers ) Tj 2.294444 0 Td 58.333333 Tz (and ) Tj 1.283333 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 44.074074 Tz (like\) ) Tj 1.555556 0 Td 62.222222 Tz (shown ) Tj 2.1 0 Td 51.851852 Tz (as ) Tj 0.875 0 Td 44.560185 Tz (distinct ) Tj 2.372222 0 Td 48.611111 Tz (for ) Tj 1.069444 0 Td 66.975309 Tz (pur ) Tj 51.428571 0 0 51.428571 0 504.264312 Tm 6.358333 0 Td 53.796296 Tz (poses ) Tj 1.808333 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 43.479938 Tz (illustration ) Tj 3.383333 0 Td 66.975309 Tz (may ) Tj 1.4 0 Td 58.333333 Tz (be ) Tj 0.894444 0 Td 51.311728 Tz (incorporated ) Tj 3.908333 0 Td 50.231481 Tz (within ) Tj 2.002778 0 Td 51.851852 Tz (other ) Tj 1.711111 0 Td 64.00463 Tz (func ) Tj 51.428571 0 0 51.428571 0 460.325554 Tm 6.338889 0 Td 45.910494 Tz (tional ) Tj 1.788889 0 Td 51.131687 Tz (elements, ) Tj 2.897222 0 Td 51.131687 Tz (separated ) Tj 2.858333 0 Td 46.990741 Tz (in ) Tj 0.719444 0 Td 45.730453 Tz (different ) Tj 2.586111 0 Td 55.902778 Tz (hardware ) Tj 2.819444 0 Td 53.472222 Tz (or ) Tj 0.719444 0 Td 47.43266 Tz (distributed ) Tj 51.428571 0 0 51.428571 0 425.150115 Tm 6.358333 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 46.990741 Tz (particular ) Tj 2.994444 0 Td 52.283951 Tz (implementation. ) Tj 51.428571 0 0 51.428571 0 377.564069 Tm 7.097222 0 Td 58.981481 Tz (While ) Tj 2.1 0 Td 46.759259 Tz (certain ) Tj 2.294444 0 Td 59.806397 Tz (embodiments ) Tj 4.277778 0 Td 53.292181 Tz (according ) Tj 3.227778 0 Td 43.75 Tz (to ) Tj 0.894444 0 Td 49.691358 Tz (the ) Tj 1.225 0 Td 50.771605 Tz (invention ) Tj 51.428571 0 0 51.428571 0 335.591083 Tm 6.338889 0 Td 57.523148 Tz (have ) Tj 1.594444 0 Td 56.712963 Tz (been ) Tj 1.613889 0 Td 48.935185 Tz (described, ) Tj 3.188889 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 49.331276 Tz (invention ) Tj 2.897222 0 Td 40.509259 Tz (is ) Tj 0.738889 0 Td 50.771605 Tz (not ) Tj 1.127778 0 Td 49.537037 Tz (limited ) Tj 2.275 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 46.990741 Tz (just ) Tj 1.322222 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 294.163636 Tm 6.358333 0 Td 51.851852 Tz (described ) Tj 3.052778 0 Td 56.712963 Tz (embodiments. ) Tj 4.394444 0 Td 51.851852 Tz (Various ) Tj 2.469444 0 Td 55.555556 Tz (changes ) Tj 2.605556 0 Td 52.932099 Tz (and/or ) Tj 2.197222 0 Td 57.118056 Tz (modifica ) Tj 51.428571 0 0 51.428571 0 251.523002 Tm 6.338889 0 Td 47.314815 Tz (tions ) Tj 1.555556 0 Td 56.17284 Tz (can ) Tj 1.186111 0 Td 55.092593 Tz (be ) Tj 0.836111 0 Td 66.435185 Tz (made ) Tj 1.730556 0 Td 43.75 Tz (to ) Tj 0.661111 0 Td 58.333333 Tz (any ) Tj 1.205556 0 Td 55.092593 Tz (of ) Tj 0.758333 0 Td 49.691358 Tz (the ) Tj 1.030556 0 Td 51.49177 Tz (described ) Tj 2.897222 0 Td 59.511785 Tz (embodiments ) Tj 4.083333 0 Td 64.00463 Tz (with ) Tj 51.428571 0 0 51.428571 0 213.016069 Tm 6.358333 0 Td 52.932099 Tz (out ) Tj 1.127778 0 Td 50.771605 Tz (departing ) Tj 2.936111 0 Td 57.523148 Tz (from ) Tj 1.575 0 Td 49.691358 Tz (the ) Tj 1.069444 0 Td 42.12963 Tz (spirit ) Tj 1.711111 0 Td 50.231481 Tz (or ) Tj 0.758333 0 Td 55.740741 Tz (scope ) Tj 1.866667 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 47.638889 Tz (invention. ) Tj 3.013889 0 Td 51.203704 Tz (Also, ) Tj 51.428571 0 0 51.428571 0 168.833124 Tm 6.358333 0 Td 50.462963 Tz (various ) Tj 2.469444 0 Td 54.282407 Tz (combinations ) Tj 4.258333 0 Td 58.333333 Tz (of ) Tj 0.952778 0 Td 51.131687 Tz (elements, ) Tj 3.130556 0 Td 44.830247 Tz (steps, ) Tj 1.963889 0 Td 46.090535 Tz (features, ) Tj 2.819444 0 Td 52.932099 Tz (and/or ) Tj 30 0 0 30 0 2755 Tm 41.833333 0 Td 72.222222 Tz (5 ) Tj 30 0 0 30 0 2547 Tm 41.666667 0 Td 75 Tz (10 ) Tj 30 0 0 30 0 2339 Tm 41.666667 0 Td 72.222222 Tz (15 ) Tj 30 0 0 30 0 1923 Tm 41.6 0 Td 77.777778 Tz (25 ) Tj 30 0 0 30 0 1507 Tm 41.6 0 Td 77.777778 Tz (35 ) Tj 30 0 0 30 0 1299 Tm 41.566667 0 Td 83.333333 Tz (40 ) Tj 30 0 0 30 0 1091 Tm 41.566667 0 Td 80.555556 Tz (45 ) Tj 30 0 0 30 0 883 Tm 41.6 0 Td 80.555556 Tz (50 ) Tj 30 0 0 30 0 675 Tm 41.6 0 Td 77.777778 Tz (55 ) Tj 30 0 0 30 0 467 Tm 41.633333 0 Td 77.777778 Tz (60 ) Tj 30 0 0 30 0 259 Tm 41.633333 0 Td 75 Tz (65 ) Tj 52.857143 0 0 52.857143 0 2968 Tm 32.691892 0 Td 72.522523 Tz (16 ) Tj 51.428571 0 0 51.428571 0 2915.234583 Tm 25.297222 0 Td 49.537037 Tz (aspects ) Tj 2.294444 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 51.851852 Tz (described ) Tj 2.975 0 Td 59.217172 Tz (embodiments ) Tj 4.102778 0 Td 50.771605 Tz (are ) Tj 1.069444 0 Td 50.231481 Tz (possible ) Tj 2.586111 0 Td 59.41358 Tz (and ) Tj 1.263889 0 Td 71.296296 Tz (con ) Tj 51.428571 0 0 51.428571 0 2874.808717 Tm 25.277778 0 Td 53.652263 Tz (templated ) Tj 3.052778 0 Td 56.712963 Tz (even ) Tj 1.555556 0 Td 42.12963 Tz (if ) Tj 0.622222 0 Td 55.092593 Tz (such ) Tj 1.536111 0 Td 54.282407 Tz (combinations ) Tj 4.102778 0 Td 49.691358 Tz (are ) Tj 1.088889 0 Td 51.851852 Tz (not ) Tj 1.088889 0 Td 50.771605 Tz (expressly ) Tj 2.936111 0 Td 62.384259 Tz (iden ) Tj 40 0 0 40 0 2838 Tm 32.5 0 Td 54.166667 Tz (tified ) Tj 2.15 0 Td 61.309524 Tz (herein. ) Tj 40 0 0 40 0 2796 Tm 33.45 0 Td 81.944444 Tz (The ) Tj 1.725 0 Td 63.888889 Tz (invention ) Tj 3.7 0 Td 70.238095 Tz (claimed ) Tj 3.175 0 Td 45.833333 Tz (is: ) Tj 51.428571 0 0 51.428571 0 2749.603254 Tm 26.036111 0 Td 42.12963 Tz (1. ) Tj 0.641667 0 Td 87.5 Tz (A ) Tj 0.661111 0 Td 59.953704 Tz (method ) Tj 2.275 0 Td 49.691358 Tz (for ) Tj 0.991667 0 Td 46.990741 Tz (training ) Tj 2.391667 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 44.907407 Tz (classification ) Tj 3.908333 0 Td 51.851852 Tz (algorithm ) Tj 2.955556 0 Td 46.990741 Tz (to ) Tj 0.719444 0 Td 48.070988 Tz (detect ) Tj 51.428571 0 0 51.428571 0 2709.419301 Tm 25.297222 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 50.87963 Tz (pathology, ) Tj 3.227778 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 59.41358 Tz (method ) Tj 2.352778 0 Td 51.557239 Tz (comprising: ) Tj 51.428571 0 0 51.428571 0 2666.33 Tm 26.016667 0 Td 49.691358 Tz (for ) Tj 0.991667 0 Td 58.333333 Tz (a ) Tj 0.466667 0 Td 45.730453 Tz (plurality ) Tj 2.644444 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 57.253086 Tz (pseudo ) Tj 2.197222 0 Td 54.228395 Tz (two-dimensional ) Tj 5.075 0 Td 50.231481 Tz (data ) Tj 1.361111 0 Td 44.560185 Tz (sets ) Tj 1.244444 0 Td 55.092593 Tz (of ) Tj 0.719444 0 Td 72.376543 Tz (one ) Tj 51.428571 0 0 51.428571 0 2624.143043 Tm 26.755556 0 Td 53.324916 Tz (dimensional ) Tj 3.772222 0 Td 50.231481 Tz (data ) Tj 1.380556 0 Td 46.759259 Tz (points, ) Tj 2.158333 0 Td 55.902778 Tz (each ) Tj 1.536111 0 Td 56.712963 Tz (pseudo ) Tj 2.275 0 Td 54.228395 Tz (two-dimensional ) Tj 51.428571 0 0 51.428571 0 2583.956276 Tm 26.755556 0 Td 49.421296 Tz (data ) Tj 1.497222 0 Td 50.555556 Tz (point ) Tj 1.847222 0 Td 49.691358 Tz (representing ) Tj 3.908333 0 Td 76.157407 Tz (RNFL ) Tj 2.138889 0 Td 49.691358 Tz (thickness ) Tj 3.033333 0 Td 49.691358 Tz (values ) Tj 2.1 0 Td 48.611111 Tz (for ) Tj 1.166667 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 2542.640514 Tm 26.775 0 Td 48.611111 Tz (Subject ) Tj 2.352778 0 Td 59.41358 Tz (and ) Tj 1.419444 0 Td 53.347578 Tz (corresponding ) Tj 4.491667 0 Td 52.5 Tz (index ) Tj 1.944444 0 Td 50.231481 Tz (values ) Tj 2.177778 0 Td 47.530864 Tz (for ) Tj 1.147222 0 Td 50.771605 Tz (the ) Tj 1.263889 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 2505 Tm 26.755556 0 Td 45.833333 Tz (points: ) Tj 51.428571 0 0 51.428571 0 2459.078562 Tm 26.016667 0 Td 54.768519 Tz (performing ) Tj 3.519444 0 Td 43.518519 Tz (fractal ) Tj 2.1 0 Td 48.611111 Tz (analysis ) Tj 2.605556 0 Td 56.712963 Tz (on ) Tj 0.913889 0 Td 51.851852 Tz (the ) Tj 1.166667 0 Td 50.231481 Tz (data ) Tj 1.438889 0 Td 45.37037 Tz (set ) Tj 1.030556 0 Td 46.990741 Tz (to ) Tj 0.816667 0 Td 48.251029 Tz (calculate ) Tj 2.819444 0 Td 58.333333 Tz (a ) Tj 51.428571 0 0 51.428571 0 2416.04878 Tm 26.755556 0 Td 45.37037 Tz (plurality ) Tj 2.663889 0 Td 56.712963 Tz (of ) Tj 0.777778 0 Td 43.981481 Tz (fractal ) Tj 2.022222 0 Td 53.030303 Tz (dimensions; ) Tj 3.694444 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 2377.243767 Tm 26.755556 0 Td 48.316498 Tz (calculating ) Tj 3.480556 0 Td 51.851852 Tz (a ) Tj 0.583333 0 Td 45.730453 Tz (plurality ) Tj 2.780556 0 Td 56.712963 Tz (of ) Tj 0.894444 0 Td 49.691358 Tz (slopes ) Tj 2.080556 0 Td 57.407407 Tz (between ) Tj 2.683333 0 Td 55.902778 Tz (each ) Tj 1.652778 0 Td 43.981481 Tz (fractal ) Tj 48.571429 0 0 48.571429 0 2333 Tm 29.091176 0 Td 56.617647 Tz (dimension; ) Tj 51.428571 0 0 51.428571 0 2295.215124 Tm 26.016667 0 Td 57.973251 Tz (combining ) Tj 3.383333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 45.37037 Tz (plurality ) Tj 2.702778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 50.231481 Tz (slopes ) Tj 2.061111 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 48.611111 Tz (subjects ) Tj 2.605556 0 Td 50 Tz (labeled ) Tj 2.313889 0 Td 51.851852 Tz (as ) Tj 51.428571 0 0 51.428571 0 2253.024 Tm 26.755556 0 Td 50.87963 Tz (pathologic ) Tj 3.266667 0 Td 46.180556 Tz (into ) Tj 1.302778 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 50.87963 Tz (pathologic ) Tj 3.247222 0 Td 51.041667 Tz (data ) Tj 1.419444 0 Td 39.699074 Tz (set; ) Tj 51.428571 0 0 51.428571 0 2211.215124 Tm 26.016667 0 Td 57.973251 Tz (combining ) Tj 3.383333 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 45.37037 Tz (plurality ) Tj 2.702778 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 50.231481 Tz (slopes ) Tj 2.061111 0 Td 48.611111 Tz (for ) Tj 1.088889 0 Td 48.611111 Tz (subjects ) Tj 2.605556 0 Td 50 Tz (labeled ) Tj 2.313889 0 Td 51.851852 Tz (as ) Tj 51.428571 0 0 51.428571 0 2168.801296 Tm 26.736111 0 Td 50.925926 Tz (healthy ) Tj 2.333333 0 Td 46.990741 Tz (into ) Tj 1.302778 0 Td 58.333333 Tz (a ) Tj 0.505556 0 Td 50.925926 Tz (healthy ) Tj 2.333333 0 Td 51.041667 Tz (data ) Tj 1.419444 0 Td 39.699074 Tz (set; ) Tj 1.166667 0 Td 59.41358 Tz (and ) Tj 51.428571 0 0 51.428571 0 2125.962963 Tm 26.016667 0 Td 53.472222 Tz (applying ) Tj 2.761111 0 Td 58.333333 Tz (a ) Tj 0.583333 0 Td 46.990741 Tz (linear ) Tj 1.886111 0 Td 50.771605 Tz (discriminant ) Tj 3.869444 0 Td 50.231481 Tz (function ) Tj 2.644444 0 Td 46.990741 Tz (to ) Tj 0.797222 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 51.203704 Tz (pathologic ) Tj 51.428571 0 0 51.428571 0 2084.046512 Tm 26.755556 0 Td 51.041667 Tz (data ) Tj 1.4 0 Td 45.37037 Tz (set ) Tj 0.952778 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 50.925926 Tz (healthy ) Tj 2.333333 0 Td 51.041667 Tz (data ) Tj 1.419444 0 Td 39.699074 Tz (set; ) Tj 51.428571 0 0 51.428571 0 2043.994688 Tm 25.997222 0 Td 52.314815 Tz (thereby ) Tj 2.488889 0 Td 47.800926 Tz (training ) Tj 2.605556 0 Td 55.092593 Tz (a ) Tj 0.622222 0 Td 45.138889 Tz (classification ) Tj 4.102778 0 Td 52.211934 Tz (algorithm ) Tj 3.130556 0 Td 46.990741 Tz (to ) Tj 0.875 0 Td 48.611111 Tz (detect ) Tj 2.061111 0 Td 49.691358 Tz (the ) Tj 51.428571 0 0 51.428571 0 2003.972112 Tm 26.755556 0 Td 43.981481 Tz (retinal ) Tj 2.022222 0 Td 50.555556 Tz (pathology. ) Tj 51.428571 0 0 51.428571 0 1957.640854 Tm 26.016667 0 Td 43.75 Tz (2. ) Tj 0.719444 0 Td 63.734568 Tz (The ) Tj 1.380556 0 Td 59.41358 Tz (method ) Tj 2.313889 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 53.796296 Tz (claim ) Tj 1.847222 0 Td 43.75 Tz (1, ) Tj 0.738889 0 Td 55.092593 Tz (wherein ) Tj 2.527778 0 Td 54.282407 Tz (each ) Tj 1.516667 0 Td 50.231481 Tz (data ) Tj 1.419444 0 Td 45.37037 Tz (set ) Tj 1.011111 0 Td 60.493827 Tz (was ) Tj 1.302778 0 Td 64.814815 Tz (pre ) Tj 51.428571 0 0 51.428571 0 1920.529623 Tm 25.297222 0 Td 50.462963 Tz (viously ) Tj 2.313889 0 Td 50.462963 Tz (labeled ) Tj 2.275 0 Td 51.851852 Tz (as ) Tj 0.777778 0 Td 51.527778 Tz (pathologic ) Tj 3.305556 0 Td 50.231481 Tz (or ) Tj 0.738889 0 Td 47.395833 Tz (healthy. ) Tj 51.428571 0 0 51.428571 0 1876.857875 Tm 26.016667 0 Td 43.75 Tz (3. ) Tj 0.719444 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 59.41358 Tz (method ) Tj 2.294444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 52.932099 Tz (claims ) Tj 2.1 0 Td 45.37037 Tz (2, ) Tj 0.719444 0 Td 55.555556 Tz (wherein ) Tj 2.527778 0 Td 49.016204 Tz (labeling ) Tj 2.547222 0 Td 37.268519 Tz (is ) Tj 0.622222 0 Td 56.893004 Tz (performed ) Tj 51.428571 0 0 51.428571 0 1832.888889 Tm 25.277778 0 Td 61.574074 Tz (by ) Tj 0.913889 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 65.462963 Tz (human ) Tj 2.158333 0 Td 53.472222 Tz (or ) Tj 0.758333 0 Td 58.333333 Tz (a ) Tj 0.544444 0 Td 54.282407 Tz (machine. ) Tj 51.428571 0 0 51.428571 0 1793.270968 Tm 26.016667 0 Td 43.75 Tz (4. ) Tj 0.719444 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 59.41358 Tz (method ) Tj 2.294444 0 Td 59.953704 Tz (of ) Tj 0.797222 0 Td 53.796296 Tz (claim ) Tj 1.847222 0 Td 40.509259 Tz (1, ) Tj 0.7 0 Td 47.685185 Tz (further ) Tj 2.158333 0 Td 51.851852 Tz (comprising: ) Tj 51.428571 0 0 51.428571 0 1754.020602 Tm 26.016667 0 Td 49.016204 Tz (labeling ) Tj 2.508333 0 Td 55.902778 Tz (each ) Tj 1.555556 0 Td 50.231481 Tz (data ) Tj 1.380556 0 Td 45.37037 Tz (set ) Tj 0.991667 0 Td 48.611111 Tz (as ) Tj 0.777778 0 Td 51.203704 Tz (pathologic ) Tj 3.266667 0 Td 51.851852 Tz (or ) Tj 0.758333 0 Td 47.395833 Tz (healthy. ) Tj 51.428571 0 0 51.428571 0 1709.529716 Tm 26.016667 0 Td 43.75 Tz (5. ) Tj 0.7 0 Td 63.734568 Tz (The ) Tj 1.322222 0 Td 59.953704 Tz (method ) Tj 2.313889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 53.148148 Tz (claim ) Tj 1.808333 0 Td 42.12963 Tz (1, ) Tj 0.7 0 Td 55.092593 Tz (wherein ) Tj 2.488889 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 43.518519 Tz (retinal ) Tj 2.002778 0 Td 53.292181 Tz (pathology ) Tj 3.072222 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1670.010152 Tm 25.316667 0 Td 48.611111 Tz (selected ) Tj 2.605556 0 Td 58.333333 Tz (from ) Tj 1.711111 0 Td 49.691358 Tz (the ) Tj 1.147222 0 Td 57.037037 Tz (group ) Tj 2.022222 0 Td 48.935185 Tz (consisting ) Tj 3.227778 0 Td 55.092593 Tz (of ) Tj 1.069444 0 Td 56.17284 Tz (glaucoma, ) Tj 3.344444 0 Td 56.018519 Tz (macular ) Tj 41.428571 0 0 41.428571 0 1631 Tm 31.403448 0 Td 67.816092 Tz (ederma. ) Tj 51.428571 0 0 51.428571 0 1584.270968 Tm 26.036111 0 Td 42.12963 Tz (6. ) Tj 0.7 0 Td 63.734568 Tz (The ) Tj 1.341667 0 Td 60.493827 Tz (method ) Tj 2.333333 0 Td 58.333333 Tz (of ) Tj 0.797222 0 Td 53.148148 Tz (claim ) Tj 1.827778 0 Td 42.12963 Tz (1, ) Tj 0.7 0 Td 47.685185 Tz (further ) Tj 2.158333 0 Td 51.851852 Tz (comprising: ) Tj 51.428571 0 0 51.428571 0 1542.617466 Tm 26.016667 0 Td 50.05144 Tz (receiving ) Tj 2.8 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 45.730453 Tz (plurality ) Tj 2.605556 0 Td 55.092593 Tz (of ) Tj 0.738889 0 Td 53.580247 Tz (one-dimensional ) Tj 5.016667 0 Td 76.157407 Tz (RNFL ) Tj 1.944444 0 Td 50.231481 Tz (data ) Tj 1.361111 0 Td 44.560185 Tz (sets ) Tj 1.186111 0 Td 59.953704 Tz (of ) Tj 51.428571 0 0 51.428571 0 1500.020202 Tm 26.755556 0 Td 53.796296 Tz (one-dimensional ) Tj 4.958333 0 Td 50.231481 Tz (data ) Tj 1.322222 0 Td 46.759259 Tz (points, ) Tj 2.080556 0 Td 56.712963 Tz (each ) Tj 1.477778 0 Td 53.580247 Tz (one-dimensional ) Tj 4.977778 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1459.838356 Tm 26.755556 0 Td 49.259259 Tz (point ) Tj 1.75 0 Td 49.421296 Tz (representing ) Tj 3.733333 0 Td 58.333333 Tz (an ) Tj 0.952778 0 Td 76.157407 Tz (RNFL ) Tj 2.041667 0 Td 50.05144 Tz (thickness ) Tj 2.955556 0 Td 50.555556 Tz (value ) Tj 1.75 0 Td 47.530864 Tz (for ) Tj 1.011111 0 Td 55.092593 Tz (a ) Tj 0.583333 0 Td 68.055556 Tz (sub ) Tj 51.428571 0 0 51.428571 0 1419.297521 Tm 26.716667 0 Td 42.12963 Tz (ject; ) Tj 1.458333 0 Td 60.493827 Tz (and ) Tj 51.428571 0 0 51.428571 0 1376.970246 Tm 26.016667 0 Td 51.851852 Tz (converting ) Tj 3.402778 0 Td 48.611111 Tz (the ) Tj 1.147222 0 Td 45.730453 Tz (plurality ) Tj 2.780556 0 Td 58.333333 Tz (of ) Tj 0.875 0 Td 53.796296 Tz (one-dimensional ) Tj 5.211111 0 Td 76.157407 Tz (RNFL ) Tj 2.138889 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1334.511502 Tm 26.775 0 Td 43.75 Tz (sets ) Tj 1.302778 0 Td 46.990741 Tz (into ) Tj 1.380556 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 45.37037 Tz (plurality ) Tj 2.702778 0 Td 56.712963 Tz (of ) Tj 0.816667 0 Td 57.253086 Tz (pseudo ) Tj 2.294444 0 Td 54.444444 Tz (two-dimensional ) Tj 5.172222 0 Td 50.231481 Tz (data ) Tj 51.428571 0 0 51.428571 0 1294.885714 Tm 26.755556 0 Td 49.151235 Tz (points ) Tj 1.905556 0 Td 58.333333 Tz (by ) Tj 0.836111 0 Td 49.494949 Tz (associating ) Tj 3.363889 0 Td 55.092593 Tz (each ) Tj 1.458333 0 Td 49.421296 Tz (data ) Tj 1.302778 0 Td 51.203704 Tz (point ) Tj 1.652778 0 Td 45.37037 Tz (in ) Tj 0.680556 0 Td 55.092593 Tz (each ) Tj 1.477778 0 Td 61.574074 Tz (one-dimen ) Tj 51.428571 0 0 51.428571 0 1251.477569 Tm 26.775 0 Td 47.530864 Tz (sional ) Tj 2.119444 0 Td 75.347222 Tz (RNFL ) Tj 2.177778 0 Td 49.421296 Tz (data ) Tj 1.536111 0 Td 45.37037 Tz (set ) Tj 1.166667 0 Td 52.662037 Tz (with ) Tj 1.633333 0 Td 49.691358 Tz (the ) Tj 1.244444 0 Td 53.347578 Tz (corresponding ) Tj 4.511111 0 Td 53.148148 Tz (index ) Tj 40 0 0 40 0 1216 Tm 34.4 0 Td 61.111111 Tz (value. ) Tj 51.428571 0 0 51.428571 0 1167.387534 Tm 26.016667 0 Td 43.75 Tz (7. ) Tj 0.777778 0 Td 63.734568 Tz (The ) Tj 1.419444 0 Td 60.493827 Tz (method ) Tj 2.411111 0 Td 59.953704 Tz (of ) Tj 0.855556 0 Td 52.5 Tz (claim ) Tj 1.905556 0 Td 42.12963 Tz (6, ) Tj 0.777778 0 Td 55.092593 Tz (wherein ) Tj 2.586111 0 Td 49.691358 Tz (the ) Tj 1.127778 0 Td 46.090535 Tz (plurality ) Tj 2.722222 0 Td 59.953704 Tz (of ) Tj 0.875 0 Td 71.296296 Tz (one ) Tj 51.428571 0 0 51.428571 0 1127.138462 Tm 25.297222 0 Td 53.324916 Tz (dimensional ) Tj 3.869444 0 Td 75.347222 Tz (RNFL ) Tj 2.1 0 Td 51.041667 Tz (data ) Tj 1.516667 0 Td 44.560185 Tz (sets ) Tj 1.322222 0 Td 50.771605 Tz (are ) Tj 1.186111 0 Td 52.572016 Tz (generated ) Tj 3.091667 0 Td 61.574074 Tz (by ) Tj 1.011111 0 Td 56.712963 Tz (an ) Tj 0.991667 0 Td 56.481481 Tz (imaging ) Tj 40 0 0 40 0 1091 Tm 32.525 0 Td 62.5 Tz (device. ) Tj 51.428571 0 0 51.428571 0 1042.308311 Tm 26.016667 0 Td 43.75 Tz (8. ) Tj 0.738889 0 Td 63.734568 Tz (The ) Tj 1.4 0 Td 59.41358 Tz (method ) Tj 2.352778 0 Td 59.953704 Tz (of ) Tj 0.816667 0 Td 52.5 Tz (claim ) Tj 1.847222 0 Td 42.12963 Tz (7, ) Tj 0.777778 0 Td 54.166667 Tz (wherein ) Tj 2.547222 0 Td 48.611111 Tz (the ) Tj 1.108333 0 Td 56.481481 Tz (imaging ) Tj 2.586111 0 Td 52.391975 Tz (device ) Tj 2.080556 0 Td 40.509259 Tz (is ) Tj 51.428571 0 0 51.428571 0 1004.438964 Tm 25.316667 0 Td 48.611111 Tz (selected ) Tj 2.508333 0 Td 57.523148 Tz (from ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 57.037037 Tz (group ) Tj 1.886111 0 Td 49.259259 Tz (consisting ) Tj 3.130556 0 Td 55.092593 Tz (of ) Tj 0.991667 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 53.472222 Tz (scanning ) Tj 2.741667 0 Td 46.666667 Tz (laser ) Tj 1.516667 0 Td 63.194444 Tz (pola ) Tj 51.428571 0 0 51.428571 0 962.300863 Tm 25.297222 0 Td 46.990741 Tz (rimeter, ) Tj 2.469444 0 Td 58.333333 Tz (an ) Tj 0.972222 0 Td 46.296296 Tz (optical ) Tj 2.197222 0 Td 54.73251 Tz (coherence ) Tj 3.169444 0 Td 55.740741 Tz (tomograph, ) Tj 3.577778 0 Td 59.41358 Tz (and ) Tj 1.302778 0 Td 51.851852 Tz (a ) Tj 0.602778 0 Td 53.148148 Tz (Heidelberg ) Tj 51.428571 0 0 51.428571 0 922.333333 Tm 25.297222 0 Td 46.450617 Tz (retina ) Tj 1.808333 0 Td 55.740741 Tz (tomograph. ) Tj 48.571429 0 0 48.571429 0 877 Tm 27.547059 0 Td 46.323529 Tz (9. ) Tj 0.720588 0 Td 67.48366 Tz (The ) Tj 1.420588 0 Td 62.908497 Tz (method ) Tj 2.45 0 Td 58.333333 Tz (of ) Tj 0.782353 0 Td 56.27451 Tz (claim ) Tj 1.873529 0 Td 46.323529 Tz (1, ) Tj 0.720588 0 Td 58.823529 Tz (wherein ) Tj 2.676471 0 Td 51.470588 Tz (the ) Tj 1.091176 0 Td 46.078431 Tz (fractal ) Tj 2.141176 0 Td 58.714597 Tz (dimension ) Tj 3.355882 0 Td 41.176471 Tz (is ) Tj 51.428571 0 0 51.428571 0 836 Tm 25.297222 0 Td 49.259259 Tz (calculated ) Tj 3.091667 0 Td 53.148148 Tz (using ) Tj 1.730556 0 Td 55.092593 Tz (a ) Tj 0.466667 0 Td 52.572016 Tz (technique ) Tj 2.975 0 Td 49.016204 Tz (selected ) Tj 2.488889 0 Td 58.333333 Tz (from ) Tj 1.555556 0 Td 50.771605 Tz (the ) Tj 1.030556 0 Td 56.388889 Tz (group ) Tj 1.866667 0 Td 53.703704 Tz (consist ) Tj 51.428571 0 0 51.428571 0 795.930175 Tm 25.297222 0 Td 50.771605 Tz (ing ) Tj 1.166667 0 Td 53.472222 Tz (of ) Tj 0.991667 0 Td 51.851852 Tz (a ) Tj 0.525 0 Td 54.012346 Tz (box-counting ) Tj 4.083333 0 Td 52.932099 Tz (technique ) Tj 3.052778 0 Td 58.333333 Tz (and ) Tj 1.263889 0 Td 51.851852 Tz (a ) Tj 0.544444 0 Td 46.018519 Tz (fractional ) Tj 2.994444 0 Td 59.548611 Tz (Brownian ) Tj 51.428571 0 0 51.428571 0 754.769231 Tm 25.297222 0 Td 56.712963 Tz (motion ) Tj 2.216667 0 Td 50.231481 Tz (technique. ) Tj 48.571429 0 0 48.571429 0 711 Tm 27.567647 0 Td 51.470588 Tz (10. ) Tj 1.029412 0 Td 68.627451 Tz (The ) Tj 1.379412 0 Td 63.480392 Tz (method ) Tj 2.408824 0 Td 56.617647 Tz (of ) Tj 0.761765 0 Td 56.27451 Tz (claim ) Tj 1.791176 0 Td 51.470588 Tz (9, ) Tj 0.741176 0 Td 59.313725 Tz (wherein ) Tj 2.573529 0 Td 53.75817 Tz (the ) Tj 1.111765 0 Td 46.078431 Tz (fractal ) Tj 2.079412 0 Td 59.477124 Tz (dimension ) Tj 3.335294 0 Td 41.176471 Tz (is ) Tj 51.428571 0 0 51.428571 0 671.789809 Tm 25.297222 0 Td 49.259259 Tz (calculated ) Tj 3.130556 0 Td 52.5 Tz (using ) Tj 1.730556 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 45.37037 Tz (plurality ) Tj 2.663889 0 Td 56.712963 Tz (of ) Tj 0.758333 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 49.789562 Tz (techniques. ) Tj 51.428571 0 0 51.428571 0 628.2 Tm 26.055556 0 Td 48.611111 Tz (11. ) Tj 1.030556 0 Td 63.734568 Tz (The ) Tj 1.361111 0 Td 59.953704 Tz (method ) Tj 2.313889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 54.444444 Tz (claim ) Tj 1.866667 0 Td 42.12963 Tz (1, ) Tj 0.680556 0 Td 47.685185 Tz (further ) Tj 2.177778 0 Td 51.851852 Tz (comprising: ) Tj 51.428571 0 0 51.428571 0 591.22807 Tm 26.016667 0 Td 53.472222 Tz (applying ) Tj 2.761111 0 Td 47.530864 Tz (principal ) Tj 2.8 0 Td 58.009259 Tz (components ) Tj 3.694444 0 Td 48.611111 Tz (analysis ) Tj 2.527778 0 Td 48.611111 Tz (to ) Tj 0.777778 0 Td 50.771605 Tz (the ) Tj 1.108333 0 Td 51.203704 Tz (pathologic ) Tj 51.428571 0 0 51.428571 0 544.051282 Tm 26.755556 0 Td 51.041667 Tz (data ) Tj 1.4 0 Td 45.37037 Tz (set ) Tj 0.952778 0 Td 60.493827 Tz (and ) Tj 1.244444 0 Td 50.771605 Tz (the ) Tj 1.069444 0 Td 50.925926 Tz (healthy ) Tj 2.333333 0 Td 51.041667 Tz (data ) Tj 1.419444 0 Td 38.888889 Tz (set. ) Tj 48.571429 0 0 48.571429 0 503 Tm 27.567647 0 Td 51.470588 Tz (12. ) Tj 1.070588 0 Td 67.48366 Tz (The ) Tj 1.4 0 Td 62.336601 Tz (method ) Tj 2.408824 0 Td 58.333333 Tz (of ) Tj 0.782353 0 Td 56.27451 Tz (claim ) Tj 1.894118 0 Td 44.607843 Tz (1, ) Tj 0.7 0 Td 58.333333 Tz (wherein ) Tj 2.635294 0 Td 51.470588 Tz (the ) Tj 1.091176 0 Td 49.183007 Tz (linear ) Tj 1.894118 0 Td 53.472222 Tz (discriminant ) Tj 40 0 0 40 0 467 Tm 32.525 0 Td 64.583333 Tz (function ) Tj 3.35 0 Td 50 Tz (is ) Tj 0.9 0 Td 61.458333 Tz (Fisher's ) Tj 3.2 0 Td 60.416667 Tz (linear ) Tj 2.375 0 Td 64.930556 Tz (discriminant ) Tj 4.9 0 Td 61.574074 Tz (function. ) Tj 51.428571 0 0 51.428571 0 420.831858 Tm 26.036111 0 Td 48.611111 Tz (13. ) Tj 1.069444 0 Td 84.259259 Tz (A ) Tj 0.680556 0 Td 53.376906 Tz (computer-readable ) Tj 5.658333 0 Td 64.814815 Tz (medium ) Tj 2.547222 0 Td 62.222222 Tz (whose ) Tj 2.041667 0 Td 50.231481 Tz (contents ) Tj 2.605556 0 Td 53.796296 Tz (cause ) Tj 1.788889 0 Td 55.092593 Tz (a ) Tj 51.428571 0 0 51.428571 0 379.55102 Tm 25.297222 0 Td 57.523148 Tz (computer ) Tj 2.936111 0 Td 45.37037 Tz (to ) Tj 0.738889 0 Td 55.092593 Tz (perform ) Tj 2.547222 0 Td 48.611111 Tz (the ) Tj 1.088889 0 Td 59.953704 Tz (method ) Tj 2.313889 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 53.796296 Tz (claim ) Tj 1.866667 0 Td 38.888889 Tz (1. ) Tj 51.428571 0 0 51.428571 0 339.123711 Tm 26.036111 0 Td 48.611111 Tz (14. ) Tj 1.030556 0 Td 87.5 Tz (A ) Tj 0.7 0 Td 60.493827 Tz (method ) Tj 2.333333 0 Td 58.333333 Tz (of ) Tj 0.777778 0 Td 49.331276 Tz (detecting ) Tj 2.819444 0 Td 55.092593 Tz (a ) Tj 0.525 0 Td 43.518519 Tz (retinal ) Tj 1.983333 0 Td 54.012346 Tz (pathology ) Tj 3.091667 0 Td 45.37037 Tz (in ) Tj 0.738889 0 Td 55.092593 Tz (a ) Tj 0.505556 0 Td 45.775463 Tz (Subject, ) Tj 51.428571 0 0 51.428571 0 297.191617 Tm 25.277778 0 Td 50.771605 Tz (the ) Tj 1.127778 0 Td 60.493827 Tz (method ) Tj 2.352778 0 Td 51.557239 Tz (comprising: ) Tj 51.428571 0 0 51.428571 0 254.974843 Tm 26.016667 0 Td 54.768519 Tz (performing ) Tj 3.519444 0 Td 43.518519 Tz (fractal ) Tj 2.041667 0 Td 48.611111 Tz (analysis ) Tj 2.547222 0 Td 59.953704 Tz (on ) Tj 0.933333 0 Td 58.333333 Tz (a ) Tj 0.525 0 Td 57.253086 Tz (pseudo ) Tj 2.294444 0 Td 54.228395 Tz (two-dimensional ) Tj 51.428571 0 0 51.428571 0 212.53206 Tm 26.775 0 Td 76.967593 Tz (RNFL ) Tj 2.022222 0 Td 49.421296 Tz (data ) Tj 1.380556 0 Td 45.37037 Tz (set ) Tj 0.991667 0 Td 48.611111 Tz (for ) Tj 1.05 0 Td 48.611111 Tz (the ) Tj 1.069444 0 Td 48.611111 Tz (subject ) Tj 2.236111 0 Td 43.75 Tz (to ) Tj 0.7 0 Td 48.251029 Tz (calculate ) Tj 2.780556 0 Td 51.851852 Tz (a ) Tj 0.486111 0 Td 45.730453 Tz (plurality ) Tj 2.663889 0 Td 58.333333 Tz (of ) Tj 48.571429 0 0 48.571429 0 170 Tm 28.329412 0 Td 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